Antioxidative effects of whey protein on peroxide-induced cytotoxicity

Journal of Dairy Science

Volumn 94, Issue 8, 2011, Pages 3739-3746

  Xu, R ^a   Liu, N ^a   Xu, X ^a   Kong, B ^a  

^a NORTHEAST AGRICULTURAL UNIVERSITY   (China)

Author keywords

Antioxidant; C2C12 myoblast; Hydrogen peroxide; Whey protein

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; 8-HYDROXY-2'-DEOXYGUANOSINE; ANTIOXIDANT; DEOXYGUANOSINE; DRUG DERIVATIVE; HYDROGEN PEROXIDE; INDOLE DERIVATIVE; MILK PROTEIN; QUINOLIZINE DERIVATIVE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; VINTOPEROL; WHEY PROTEIN;

ANIMAL; ARTICLE; CELL CULTURE; CELL SURVIVAL; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; LIPID PEROXIDATION; METABOLISM; MYOBLAST;

ANIMALS; ANTIOXIDANTS; CELL SURVIVAL; CELLS, CULTURED; DEOXYGUANOSINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HYDROGEN PEROXIDE; INDOLES; LIPID PEROXIDATION; MILK PROTEINS; MYOBLASTS; QUINOLIZINES; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE;

EID: 79960640957     PISSN: 00220302     EISSN: 15253198     Source Type: Journal    
DOI: 10.3168/jds.2010-3891     Document Type: Article

References (31)

1. Aoi W., Naito Y., Takanami Y., Kawai Y., Sakuma K., Ichikawa H., Yoshida N., Yoshikawa T. Oxidative stress and delayed-onset muscle damage after exercise. Free Radic. Biol. Med. 2004, 37:480-487.
2. Arisawa S., Ishida K., Kameyama N., Ueyama J., Hattori A., Tatsumi Y., Hayashi H., Yano M., Hayashi K., Katano Y., Goto H., Takagi K., Wakusawa S. Ursodeoxycholic acid induces glutathione synthesis through activation of PI3K/Akt pathway in HepG2 cells. Biochem. Pharmacol. 2009, 77:858-866.
3. Bounous G. Whey protein concentrate (WPC) and glutathione modulation in cancer treatment. Anticancer Res. 2000, 20:4785-4792.
4. Chen K., Gunter K., Maines M.D. Neurons overexpressing heme oxygenase-1 resist oxidative stress-mediated cell death. J. Neurochem. 2000, 75:304-313.
5. Davies K.J., Quintanilha A.T., Brooks G.A., Packer L. Free radicals and tissue damage produced by exercise. Biochem. Biophys. Res. Commun. 1982, 107:1198-1205.
6. Di Domenico F., Perluigi M., Foppoli C., Blarzino C., Coccia R., De Marco F., Butterfield D.A., Cini C. Protective effect of ferulic acid ethyl ester against oxidative stress mediated by UVB irradiation in human epidermal melanocytes. Free Radic. Res. 2009, 43:365-375.
7. Ewing J.F., Janero D.R. Microplate superoxide dismutase assay employing a nonenzymatic superoxide generator. Anal. Biochem. 1995, 232:243-248.
8. Gad A.S., Khadrawy Y.A., El-Nekeety A.A., Mohamed S.R., Hassan N.S., Abdel-Wahhab M.A. Antioxidant activity and hepatoprotective effects of whey protein and Spirulina in rats. Nutrition 2011, 27:582-589.
9. Ichinose T., Yajima Y., Nagashima M., Takenoshita S., Nagamachi Y., Sagai M. Lung carcinogenesis and formation of 8-hydroxy-deoxyguanosine in mice by diesel exhaust particles. Carcinogenesis 1997, 18:185-192.
10. Itoh K., Chiba T., Takahashi S., Ishii T., Igarashi K., Katoh Y., Oyake T., Hayashi N., Satoh K., Hatayama I., Yamamoto M., Nabeshima Y. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem. Biophys. Res. Commun. 1997, 236:313-322.
11. Jackson M.J., O'Farrell S. Free radicals and muscle damage. Br. Med. Bull. 1993, 49:630-641.
12. Jaiswal A.K. Nrf2 signaling in coordinated activation of antioxidant gene expression. Free Radic. Biol. Med. 2004, 36:1199-1207.
13. Johnson J.A., Johnson D.A., Kraft A.D., Calkins M.J., Jakel R.J., Vargas M.R., Chen P.C. The Nrf2-ARE pathway: An indicator and modulator of oxidative stress in neurodegeneration. Ann. N. Y. Acad. Sci. 2008, 1147:61-69.
14. Joyce N.C., Zhu C.C., Harris D.L. Relationship among oxidative stress, DNA damage, and proliferative capacity in human corneal endothelium. Invest. Ophthalmol. Vis. Sci. 2009, 50:2116-2122.
15. Kent K.D., Harper W.J., Bomser J.A. Effect of whey protein isolate on intracellular glutathione and oxidant-induced cell death in human prostate epithelial cells. Toxicol. In Vitro 2003, 17:27-33.
16. Kobayashi M., Yamamoto M. Nrf2-Keap1 regulated of cellular defense mechanisms against electrophiles and reactive oxygen species. Adv. Enzyme Regul. 2006, 46:113-140.
17. Komulainen J., Takala T.E.S., Kuipers H., Hesselink M.K. The disruption of myofibre structures in rat skeletal muscle after forced lengthening contractions. Pflugers Arch. 1998, 436:735-741.
18. Lands L.C., Grey V.L., Smountas A.A. Effect of supplementation with a cysteine donor on muscular performance. J. Appl. Physiol. 1999, 87:1381-1385.
19. Lawrence R.A., Burk R.F. Glutathione peroxidase activity in selenium-deficient rat liver. Biochem. Biophys. Res. Commun. 1976, 71:952-958.
20. Menéndez R., Más R., Amor A.M., Ledón N., Pérez J., González R.M., Rodeiro I., Zayas M., Jiménez S. Inhibition of rat lipoprotein lipid peroxidation by the oral administration of D003, a mixture of very long-chain saturated fatty acids. Can. J. Physiol. Pharmacol. 2002, 80:13-21.
21. Nguyen T., Nioi P., Pickett C.B. The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J. Biol. Chem. 2009, 284:13291-13295.
22. Sen C.K. Oxidants and antioxidants in exercise. J. Appl. Physiol. 1995, 79:675-686.
23. Siegel D., Bolton E.M., Burr J.A., Liebler D.C., Ross D. The reduction of alpha-tocopherolquinone by human NAD(P)H: Quinine oxidoreductase: The role of alpha-tocopherolhydroquinone as a cellular antioxidant. Mol. Pharmacol. 1997, 52:300-305.
24. Sjödin B., Hellsten Westing Y., Apple F.S. Biochemical mechanisms for oxygen free radical formation during exercise. Sports Med. 1990, 10:236-254.
25. Stewart D., Killeen E., Naquin R., Alam S., Alam J. Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium. J. Biol. Chem. 2003, 278:2396-2402.
26. Suttner D.M., Dennery P.A. Reversal of HO-1 related cytoprotection with increased expression is due to reactive iron. FASEB J. 1999, 13:1800-1809.
27. Vandeputte C., Guizon I., Genestie-Denis I., Vannier B., Lorenzon G. A microtiter plate assay for total glutathione and glutathione disulfide contents in cultured/isolated cells: Performance study of a new miniaturized protocol. Cell Biol. Toxicol. 1994, 10:415-421.
28. Walzem R.L., Dillard C.J., German J.B. Whey components: Millennia of evolution create functionalities for mammalian nutrition. Crit. Rev. Food Sci. Nutr. 2002, 42:353-375.
29. Wielandt A.M., Vollrath V., Farias M., Chianale J. Bucillamine induces glutathione biosynthesis via activation of the transcription factor Nrf2. Biochem. Pharmacol. 2006, 72:455-462.
30. Zhang J.-Q., Li Y.-M., Liu T., He W.-T., Chen Y.-T., Chen X.-H., Li X., Zhou W.-C., Yi J.-F., Ren Z.-J. Antitumor effect of matrine in human hepatoma G2 cells by inducing apoptosis and autophagy. World J. Gastroenterol. 2010, 16:4281-4290.
31. Zhu H., Zhang L., Itoh K., Yamamoto M., Ross D., Trush M.A., Zweier J.L., Li Y. Nrf2 controls bone marrow stromal cell susceptibility to oxidative and electrophilic stress. Free Radic. Biol. Med. 2006, 41:132-143.