Inhibition of rat lipoprotein lipid peroxidation by the oral administration of D003, a mixture of very long-chain saturated fatty acids

Canadian Journal of Physiology and Pharmacology

Volumn 80, Issue 1, 2002, Pages 13-21

  Menendez R ^a   Mas R ^a   Amor, A M ^a   Ledon N ^a   Perez J ^a   Gonzalez R M ^a   Rodeiro, I ^a   Zayas, M ^a   Jimenez S ^a  

^a NATL CENTER FOR SCIENTIFIC RESEARCH   (Cuba)

Author keywords

D003; Lipoprotein lipid peroxidation; Very long chain saturated fatty acids

Indexed keywords

ALKADIENE; AZO COMPOUND; D 003; FREE RADICAL; LOW DENSITY LIPOPROTEIN; POLICOSANOL; UNCLASSIFIED DRUG; VERY LONG CHAIN FATTY ACID; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG ISOLATION; DRUG PURIFICATION; LIPID PEROXIDATION; MACROPHAGE; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CONTENT; RAT;

ANIMALS; AZO COMPOUNDS; COPPER; DOSE-RESPONSE RELATIONSHIP, DRUG; FATTY ACIDS; LIPID PEROXIDATION; LIPOPROTEINS; LIPOPROTEINS, LDL; LIPOPROTEINS, VLDL; MACROPHAGES; MALE; RATS; RATS, WISTAR; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 0036188392     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y01-088     Document Type: Article

References (61)

1. Effects of policosanol in lowering cholesterol levels in patients with type II hypercholesterolemia
2. Cholesterol lowering effect of policosanol on normocholesterolemic rabbits
3. Modified forms of low-density lipoprotein and atherosclerosis
4. Lipoprotein metabolism in the macrophage: Implications for cholesterol deposition in atherosclerosis
5. Efficacia, seguridad y tolerabilidad del policosanol en pacientse argentinos con hipercolsterolemia tipo II. Estudio abierto
6. One-year study on the effect of policosanol (5 mg-twice-a-day) on lipid profile in patients with type II hypercholesterolemia
7. A double-blind placebo controlled study of the effect of policosanol in patients with intermittent claudication
8. A long-term open study of the efficacy and tolerability of policosanol in patients high global coronary risk
9. Effect of policosanol on postmenopausal women with type II hypercholesterolemia
10. Animal lipoprotein: Chemistry, structure and comparative aspects
11. Lysophosphatidylcholine inhibits relaxation of rabbit abdominal aorta mediated by endothelium-derived nitric oxide and endothelium-derived hyperpolarizing factor independent of protein kinase C activation
12. Flavonoids inhibit the oxidative modification of low-density lipoprotein by macrophages
13. Effect of oral supplmentation with d-alpha-tocopherol on the vitamin content of human low density lipoprotein and its oxidation resistance
14. Comparison of the efficacy and tolerability of policosanol Vs fluvastatine in elderly hypercholesterolemic women
15. Effect of policosanol on in vitro and in vivo rat liver microsomal lipid peroxidation
16. Content of antioxidant, pre-formed lipid hydroperoxides and cholesterol as predictors of susceptibility of human LDL to metal ion-dependent and independent oxidation
17. Antioxidant defenses and lipid peroxidation in human blood plasma
18. Helsinki heart study: Primary intervention trial with gemfibrozil in middle age men with dislypidemia
19. Low-density lipoprotein is saturable by pro-oxidant copper
20. Malondialdehyde-altered protein occurs in the atheroma of Watanabe heritable hyperlipidemic rabbits
21. β-carotene inhibits the oxidative modification of low density lipoprotein
22. Oxidation of low-density lipoprotein by hypochlorite causes aggregation that is mediated by modification of lysine residues rather that lipid oxidation
23. Effects of policosanol on serum lipids and lipoproteins in healthy volunteers
24. Isolation, purification and characterization of a lipoprotein containing apo B from human aorta
25. β-carotene inhibits the oxidative modification of low density lipoprotein
26. Biodistribution and metabolism of orally administered octacosanol in rats
27. 14C)-octacosanol in liver and muscle of rats after serial administration
28. Metabolism of octacosanol in liver and muscle of rats
29. Then other side of scavenger receptor: Pattern recognition for host defense
30. Serum lipoprotein of normal and cholesterol-fed rats
31. The modification of LDL by macrophages
32. The lipid research clinics primary prevention trial result. II the relationship of reduction in the incidence coronary heart disease to cholesterol-lowering
33. A modification of the Lowry procedure to simply protein determination in membrane and lipoprotein samples
34. Policosanol
35. Effects of policosanol in patients with type II hypercholesterolemia and additional coronary risk factors
36. Pharmacoepidemiologic study of policosanol
37. The effects of D003 and policosanol on the lipid profile and endothelemia in normocholesterolemic rabbits: A head to head comparison
38. Cholesterol-lowering effect of policosanol on rabbits with hypercholesteroemia induced by wheat starch-casein diet
39. Oral administration of policosanol inhibits in vitro copper ion-induced rat lipoprotein peroxidation
40. Effects of policosanol on the susceptibility of low-density lipoprotein isolated from hypercholesterolemic patients at high coronary risk to in vitro copper-mediated ;lipid peroxidation. A randomized, double-blind pilot study
41. Effects of policosanol treatment on the susceptibility of low-density lipo-protein (LDL) isolated from healthy volunteers to oxidative modification in vitro
42. Antiplatelet and antithrombotic effect of D003
43. Assay for lipid peroxides in animal tissue by TBA
44. Low-density lipoprotein rich in oleic acid is protected against oxidative modification: Implication for dietary prevention of atherosclerosis
45. Supplementation with vitamin E but not beta-carotene in vivo protects low-density lipoprotein from lipid peroxidation in vitro. Effect of cigarette smoking
46. Methods to determine oxidation of low-density lipoprotein
47. Oxidative damage to proteins. Spectrophotometric method for carbonyl assay
48. Sjögre-Laarsson syndrome. Impaired fatty alcohol oxidation in cultured fibroblasts due to deficient fatty alcohol:nicotinamide adenine nucleoside oxidoreductase activity
49. Fatty alcohol metabolism in cultured fibroblasts. Evidence for a fatty alcohol cycle
50. Effects of policosanol chronically administered in male monkeys
51. Distribution of oxidation specific lipid-protein adducts and apolipoprotein B in atherosclerotic lesions of varying severity from WHHL rabbits
52. Effect of dietary oils on lipid peroxidation and antioxidant parameters of rat plasma and lipoprotein fractions
53. Randomized trial of cholesterol-lowering in 4444 patients with coronary heart disease. The Scandinavian Simvastatin survival study (4S)
54. A comparative study of stearic acid and lignoceric acid oxidation by human skin fibroblasts
55. Very long chain acid Β-oxidation by the rat liver mitochondria and peroxisomes
56. Beyond cholesterol. Modification of low-density lipoprotein that increases its atherogenicity
57. Oxidation of human low-density lipoprotein results in derivatization of lysine residues of apolipoprotein B by lipid peroxides
58. Oxidized low-density lipoprotein inhibits relaxation of porcine coronary arteries. Role of scavenger receptor and endothelium-derived nitric oxide
59. A comparison of the kinetics of low-density lipoprotein oxidation initiated by copper or by azobis (2 amidinopropane)
60. Studies of peroxisomal oxidation of palmitate and lignocerate in rat liver