Loss of ephrin-A5 function disrupts lens fiber cell packing and leads to cataract

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 43, 2008, Pages 16620-16625

  Coopera, Margaret A ^a   Sona, Alexander I ^a   Komlosb, Daniel ^b   Suna, Yuhai ^a   Kleimanc, Norman J ^c   Zhoua, Renping ^a  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c Columbia University ^*  (United States)

Author keywords

catenin; Eph receptor; N cadherin

Indexed keywords

BETA CATENIN; EPHRIN A5; EPHRIN RECEPTOR A2; NERVE CELL ADHESION MOLECULE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATARACT; CELL ADHESION; CELL INTERACTION; CELL JUNCTION; CELL SHAPE; CONTROLLED STUDY; EYE DEVELOPMENT; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; KNOCKOUT MOUSE; LENS EPITHELIUM; LENS FIBER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; WESTERN BLOTTING; WILD TYPE;

ADHERENS JUNCTIONS; ANIMALS; CATARACT; CELL COMMUNICATION; CELL SHAPE; EPHRIN-A5; LENS, CRYSTALLINE; MICE; MICE, KNOCKOUT; RECEPTOR, EPHA2; RECEPTORS, EPH FAMILY;

MUS;

EID: 55949135635     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0808987105     Document Type: Article

References (45)

1. World Health Organization (2004) Magnitude and causes of visual impairment. WHO Fact Sheet 282 (WHO, Geneva).
2. Asbell PA, et al. (2005) Age-related cataract. Lancet 365:599-609.
3. Kuszak JR, Costello MJ (2004) in Development of the Ocular Lens, eds. Lovicu FJ, Robinson ML (Cambridge Univ. Press, Cambridge), pp. 71-118.
4. Kleiman NJ, Worgul BV (1994) Lens. Duane's Foundations of Clinical Opthalmology, vol. 1, ed Tasman W, Jaeger EA (JB Lippincott, Philadelphia), pp 1-39.
5. Goodenough DA (1992) The crystalline lens: a system networked by gap junctional intercellular communication. Semin Cell Biol 3:49-58.
6. Kistler J, et al. (1995) Ocular lens gap junctions: protein expression, assembly, and structure-function analysis. Microsc Res Tech 31:347-356.
7. Gong X, et al. (1997) Disruption of alpha3 connexin gene leads to proteolysis and cataractogenesis in mice. Cell 91:833-843.
8. White TW, Goodenough DA, Paul DL (1998) Targeted ablation of connexin50 in mice results in microphthalmia and zonular pulverulent cataracts. J Cell Biol 143:815-825.
9. White TW, Paul DL (1999) Genetic diseases and gene knockouts reveal diverse connexin functions. Annu Rev Physiol 61:283-310.
10. Wei CJ, Xu X, Lo CW (2004) Connexins and cell signaling in development and disease. Annu Rev Cell Dev Biol 20:811-838.
11. Harding JJ, Crabbe JC (1984) The lens. in The Eye, vol. 1b. ed Davson H (Academic, New York), pp 207-492.
12. Donaldson P, Kistler J, Mathias RT (2001) Molecular solutions to mammalian lens transparency. News Physiol Sci 16:118-123.
13. Bagchi M, Katar M, Lewis J, Maisel H (2002) Associated proteins of lens adherens junction. J Cell Biochem 86:700-703.
14. Lo WK, Shaw AP, Paulsen DF, Mills A (2000) Spatiotemporal distribution of zonulae adherens and associated actin bundles in both epithelium and fiber cells during chicken lens development. Exp Eye Res 71:45-55.
15. Straub BK, et al. (2003) A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells. J Cell Sci 116:4985-4995.
16. Beebe DC, Vasiliev O, Guo J, Shui YB, Bassrett S (2001) Changes in adhesion complexes define stages in the differentiation of lens fiber cells. Invest Ophthalmol Vis Sci 42:727-734.
17. Pasquale EB (2005) Eph receptor signalling casts a wide net on cell behaviour. Nat Rev Mol Cell Biol 6:462-475.
18. Zhou R (1998) The Eph family receptors and ligands. Pharmacol Ther 77:151-181.
19. Pfeiffenberger C, et al. (2005) Ephrin-As and neural activity are required for eye-specific patterning during retinogeniculate mapping. Nat Neurosci 8:1022-1027.
20. Zigler JS Jr, Horwitz J (1981) Immunochemical studies on the major intrinsic polypeptides from human lens membrane. Invest Ophthalmol Vis Sci 21:46-51.
21. Reddy VN, Lin LR, Arita T, Zigler JS Jr, Huang QL (1988) Crystallins and their synthesis in human lens epithelial cells in tissue culture. Exp Eye Res 47:465-478.
22. Chepelinsky AB (2003) The ocular lens fiber membrane specific protein MIP/Aquaporin 0. J Exp Zoolog A Comp Exp Biol 300:41-46.
23. Andley UP (2007) Crystallins in the eye: function and pathology. Prog Retin Eye Res 26:78-98.
24. Robinson ML, Overbeek PA (1996) Differential expression of alpha A- and alpha Bcrystallin during murine ocular development. Invest Ophthalmol Vis Sci 37:2276-2284.
25. Wang X, Garcia CM, Shui YB, Beebe DC (2004) Expression and regulation of alpha-, beta-, and gamma-crystallins in mammalian lens epithelial cells. Invest Ophthalmol Vis Sci 45:3608-3619.
26. Nielsen PA, et al. (2003) Lens connexins alpha3Cx46 and alpha8Cx50 interact with zonula occludens protein-1 (ZO-1). Mol Biol Cell 14:2470-2481.
27. Mellitzer G, Xu Q, Wilkinson DG (1999) Eph receptors and ephrins restrict cell intermingling and communication. Nature 400:77-81.
28. Davy A, Bush JO, Soriano P (2006) Inhibition of gap junction communication at ectopic Eph/ephrin boundaries underlies craniofrontonasal syndrome. PLoS Biol 4:e315.
29. Matsunami H, Takeichi M (1995) Fetal brain subdivisions defined by R- and E-cadherin expressions: evidence for the role of cadherin activity in region-specific, cell-cell adhesion. Dev Biol 172:466-478.
30. Miyashita Y, Ozawa M (2007) Increased internalization of p120-uncoupled E-cadherin and a requirement for a dileucine motif in the cytoplasmic domain for endocytosis of the protein. J Biol Chem 282:11540-11548.
31. Paterson AD, Parton RG, Ferguson C, Stow JL, Yap AS (2003) Characterization of E-cadherin endocytosis in isolated MCF-7 and chinese hamster ovary cells: the initial fate of unbound E-cadherin. J Biol Chem 278:21050-21057.
32. Kon S, Tanabe K, Watanabe T, Sabe H, Satake M (2008) Clathrin dependent endocytosis of E-cadherin is regulated by the Arf6GAP isoform SMAP1. Exp Cell Res 314:1415-1428.
33. Arikkath J, Reichardt LF (2008) Cadherins and catenins at synapses: roles in synaptogenesis and synaptic plasticity. Trends Neurosci, in press.
34. Marcus RC, Matthews GA, Gale NW, Yancopoulos GD, Mason CA (2000) Axon guidance in the mouse optic chiasm: retinal neurite inhibition by ephrin "A"-expressing hypothalamic cells in vitro. Dev Biol 221:132-147.
35. Lilien J, Balsamo J (2005) The regulation of cadherin-mediated adhesion by tyrosine phosphorylation/dephosphorylation of beta-catenin. Curr Opin Cell Biol 17:459-465.
36. Yap AS, Brieher WM, Gumbiner BM (1997) Molecular and functional analysis of cadherin-based adherens junctions. Annu Rev Cell Dev Biol 13:119-146.
37. Lawrenson ID, et al. (2002) Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling. J Cell Sci 115:1059-1072.
38. Cain S, et al. (2008) Differential requirement for beta-catenin in epithelial and fiber cells during lens development. Dev Biol, in press.
39. Kreslova J, et al. (2007) Abnormal lens morphogenesis and ectopic lens formation in the absence of beta-catenin function. Genesis 45:157-168.
40. Smith AN, Miller LA, Song N, Taketo MM, Lang RA (2005) The duality of beta-catenin function: a requirement in lens morphogenesis and signaling suppression of lens fate in periocular ectoderm. Dev Biol 285:477-489.
41. Noren NK, Foos G, Hauser CA, Pasquale EB (2006) The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl-Crk pathway. Nat Cell Biol 8:815-825.
42. Cortina C, et al. (2007) EphB-ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells. Nat Genet 39:1376-1383.
43. Zantek ND, et al. (1999) E-cadherin regulates the function of the EphA2 receptor tyrosine kinase. Cell Growth Differ 10:629-638.
44. Hess AR, Margaryan NV, Seftor EA, Hendrix MJ (2007) Deciphering the signaling events that promote melanoma tumor cell vasculogenic mimicry and their link to embryonic vasculogenesis: role of the Eph receptors. Dev Dyn 236:3283-3296.
45. Orsulic S, Kemler R (2000) Expression of Eph receptors and ephrins is differentially regulated by E-cadherin. J Cell Sci 113:1793-1802.