EPHA2 is associated with age-related cortical cataract in mice and humans

PLoS Genetics

Volumn 5, Issue 7, 2009, Pages

  Jun, Gyungah ^a   Guo, Hong ^a   Klein, Barbara E K ^b   Klein, Ronald ^b   Jie, Jin Wang ^c,d   Mitchell, Paul ^c   Miao, Hui ^a   Lee, Kristine E ^b   Joshi, Tripti ^a   Buck, Matthias ^a   Chugha, Preeti ^a   Bardenstein, David ^a   Klein, Alison P ^e   Bailey Wilson, Joan E ^f   Gong, Xiaohua ^g   Spector, Tim D ^h   Andrew, Toby ^h   Hammond, Christopher J ^h   Elston, Robert C ^h   Iyengar, Sudha K ^a   Wang, Bingcheng ^a   more..

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c UNIVERSITY OF SYDNEY   (Australia)

^d UNIVERSITY OF MELBOURNE   (Australia)

^e JOHNS HOPKINS UNIVERSITY   (United States)

^f NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; EPHRIN RECEPTOR A2; GLUTAMINE; HEAT SHOCK PROTEIN 25; HEAT SHOCK PROTEIN 27; PROTEIN KINASE;

ADULT; AGE DISTRIBUTION; AGED; AGING; AMINO ACID SUBSTITUTION; ANIMAL MODEL; ARTICLE; CATARACT; CAUCASIAN; CELL DIFFERENTIATION; CELL STRESS; CELL VACUOLE; CHEMICAL ANALYSIS; CHROMOSOME 1P; CONTROLLED STUDY; DISEASE COURSE; DISEASE DURATION; EPITHELIUM CELL; EXON; FEMALE; GENE DELETION; GENE FREQUENCY; GENE OVEREXPRESSION; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC VARIABILITY; HUMAN; ILLUMINATION; LENS; LENS FIBER; MAJOR CLINICAL STUDY; MALE; MISSENSE MUTATION; MOUSE; NONHUMAN; POPULATION BASED CASE CONTROL STUDY; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RECEPTOR UPREGULATION; RETINA MACULA AGE RELATED DEGENERATION; RETROILLUMINATION; SINGLE NUCLEOTIDE POLYMORPHISM; VISUAL CORTEX; AGE; ANIMAL; C57BL MOUSE; CHEMISTRY; CHROMOSOME 1; COHORT ANALYSIS; DISEASE MODEL; GENETICS; META ANALYSIS; METABOLISM; MIDDLE AGED; MOLECULAR GENETICS; MOUSE MUTANT; MUTATION; PATHOLOGY; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT;

MURINAE; MUS;

AGE FACTORS; AGED; ANIMALS; CATARACT; CHROMOSOMES, HUMAN, PAIR 1; COHORT STUDIES; DISEASE MODELS, ANIMAL; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; HUMANS; LENS, CRYSTALLINE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTATION; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, EPHA2; SEQUENCE ALIGNMENT; VISUAL CORTEX;

EID: 68249120153     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1000584     Document Type: Article

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