In Vitro Generation of Functional Lens-Like Structures with Relevance to Age-Related Nuclear Cataract

Investigative Ophthalmology and Visual Science

Volumn 48, Issue 3, 2007, Pages 1245-1252

  O'Connor, Michael D ^a,b,d   McAvoy, John W ^a,b,c,e  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

^d BRITISH COLUMBIA CANCER AGENCY   (Canada)

^e SYDNEY EYE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CRYSTALLIN;

AGING; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CATARACT; CELL DIFFERENTIATION; CELL GROWTH; CONTROLLED STUDY; ELECTRON MICROSCOPY; EXPLANT; FUNCTIONAL ANATOMY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LENS; LENS EPITHELIUM; NONHUMAN; PATHOLOGICAL ANATOMY; PRIORITY JOURNAL; RAT; SURFACE PROPERTY; VITREOUS BODY; ANIMAL; AQUEOUS HUMOR; CATTLE; CELL CULTURE; CONFOCAL MICROSCOPY; CYTOLOGY; EPITHELIUM CELL; FLUORESCENCE MICROSCOPY; METABOLISM; PATHOLOGY; PHYSIOLOGY; REGENERATION; ULTRASTRUCTURE; WISTAR RAT;

AGING; ANIMALS; AQUEOUS HUMOR; CATARACT; CATTLE; CELL DIFFERENTIATION; CELLS, CULTURED; CRYSTALLINS; EPITHELIAL CELLS; LENS, CRYSTALLINE; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON; MICROSCOPY, FLUORESCENCE; RATS; RATS, WISTAR; REGENERATION; VITREOUS BODY;

EID: 34047264135     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.06-0949     Document Type: Article

References (38)

1. Pizzarello L, Abiose A, Fytche T, et al. VISION 2020: The Right to Sight: a global initiative to eliminate avoidable blindness. Arch Ophthalmol. 2004;122:615-620.
2. Snellingen T, Evans JR, Ravilla T, Foster A. Surgical interventions for age-related cataract. Cochrane Database Syst Rev. 2002;CD001323.
3. Wormstone IM. Posterior capsule opacification: a cell biological perspective. Exp Eye Res. 2002;74:337-347.
4. Saika S. Relationship between posterior capsule opacification and intraocular lens biocompatibility. Prog Retin Eye Res. 2004;23:283-305.
5. Billotte C, Berdeaux G. Adverse clinical consequences of neodymium:YAG laser treatment of posterior capsule opacification. J Cataract Refract Surg. 2004;30:2064-2071.
6. Apple DJ, Peng Q, Visessook N, et al. Surgical prevention of posterior capsule opacification, 1: progress in eliminating this complication of cataract surgery. J Cataract Refract Surg. 2000;26:180-187.
7. Beebe DC, Feagans DE, Jebens HA. Lentropin: a factor in vitreous humor which promotes lens fibre cell differentiation. Proc Natl Acad Sci USA. 1980;77:490-493.
8. McAvoy JW, Chamberlain CG. Fibroblast growth factor (FGF) induces different responses in lens epithelial cells depending on its concentration. Development. 1989;107:221-228.
9. Lovicu FJ, Chamberlain CG, McAvoy JW. Differential effects of aqueous and vitreous on fibre differentiation and extracellular matrix accumulation in lens epithelial explants. Invest Ophthalmol Vis Sci. 1995;36:1459-1469.
10. Le AC, Musil LS. A novel role for FGF and extracellular signal-regulated kinase in gap junction-mediumted intercellular communication in the lens. J Cell Biol. 2001;154:197-216.
11. Le AC, Musil LS. FGF signaling in chick lens development. Dev Biol. 2001;233:394-411.
12. Golestaneh N, Fan J, Fariss RN, Lo W-K, Zelenka PS, Chepelinsky AB. Lens major intrinsic protein (MIP)/aquaporin 0 expression in rat lens epithelia explants requires fibroblast growth factor-induced ERK and JNK signaling. J Biol Chem. 2004;279:31813-31822.
13. Schulz MW, Chamberlain CG, de Iongh RU, McAvoy JW. Acidic and basic FGF in ocular medium and lens: implications for lens polarity and growth patterns. Development. 1993;118:117-126.
14. Lovicu FJ, McAvoy JW. FGF-induced lens cell proliferation and differentiation is dependent on MAPK (ERK1/2) signaling. Development. 2001;128:5075-5084.
15. Lovicu FJ, McAvoy JW. The age of rats affects the response of lens epithelial explants to fibroblast growth factor: an ultrastructural analysis. Invest Ophthalmol Vis Sci. 1992;33:2269-2278.
16. Lovicu FJ, Steven P, Saika S, McAvoy JW. Aberrant lens fibre differentiation in anterior subcapsular cataract formation: a process dependent on reduced levels of Pax6. Invest Ophthalmol Vis Sci. 2004;45:1946-1953.
17. McAvoy JW. Cell division, cell elongation and distribution of alpha-, beta- and gamma-crystallins in the rat lens. J Embryol Exp Morphol. 1978;44:149-165.
18. Liu H, Du x, Wang M, et al. Crystallin {gamma}B-I4F mutant protein binds to α-crystallin and affects lens transparency. J Biol Chem. 2005;280:25071-25078.
19. Bassnett S. The fate of the Golgi apparatus and the endoplasmic reticulum during lens fibre cell differentiation. Invest Ophthalmol Vis Sci. 1995;36:1793-1803.
20. Bassnett S. Fibre cell denucleation in the primate lens. Invest Ophthalmol Vis Sci. 1997;38:1678-1687.
21. Bassnett S, Mataic D. Chromatin degradation in differentiating fibre cells of the eye lens. J Cell Biol. 1997;137:37-49.
22. Blankenship TN, Hess JF, FitzGerald PG. Development- and differentiation-dependent reorganization of intermediate filaments in fibre cells. Invest Ophthalmol Vis Sci. 2001;42:735-742.
23. McAvoy JW. Cell division, cell elongation and the co-ordination of crystallin gene expression during lens morphogenesis in the rat. J Embryol Exp Morphol. 1978;45:271-281.
24. Sandilands A, Prescott AR, Carter JM, et al. Vimentin and CP49/filensin form distinct networks in the lens which are independently modulated during lens fibre cell differentiation. J Cell Sci. 1995;108:1397-1406.
25. Kuwabara T, Imaizumi M. Denucleation process of the lens. Invest Ophthalmol. 1974;13:973-981.
26. Kuwabara T. The maturation of the lens cell: a morphologic study. Exp Eye Res. 1975;20:427-443.
27. Kuszak JR. The ultrastructure of epithelial and fibre cells in the crystalline lens. Int Rev Cytol. 1995;163:305-350.
28. Gilliland KO, Freel CD, Lane CW, Fowler WC, Costello MJ. Multi-lamellar bodies as potential scattering particles in human age-related nuclear cataracts. Mol Vis. 2001;7:120-130.
29. McAvoy JW, Fernon VT. Neural retinas promote cell division and fibre differentiation in lens epithelial explants. Curr Eye Res. 1984;3:827-834.
30. Lovicu FJ, McAvoy JW. Growth factor regulation of lens development. Dev Biol. 2005;280:1-14.
31. Farnsworth PN, Fu SC, Burke PA, Bahia I. Ultrastructure of rat eye lens fibres. Invest Ophthalmol. 1974;13:274-279.
32. Vrensen GF, Graw J, De Wolf A. Nuclear breakdown during terminal differentiation of primary lens fibres in mice: a transmission electron microscopic study. Exp Eye Res. 1991;52:647-659.
33. Thompson JR, Deane JS, Hall AB, Rosenthal AR. Associations between lens features assessed in the Oxford Clinical Cataract Classification and Grading System. Ophthalmic Epidemiol. 1997;4:207-212.
34. Chylack LT Jr, Ransil BJ, White O. Classification of human senile cataractous change by the American Cooperative Cataract Research Group (CCRG) method, III: the association of nuclear color (sclerosis) with extent of cataract formation, age, and visual acuity. Invest Ophthalmol Vis Sci. 1984;25:174-180.
35. Bron A, Brown NAP. Classification, grading and prevention of cataract. J Int Biomed Inform Data. 1983;4:21-47.
36. Al-Ghoul KJ, Lane CW, Taylor VL, Fowler WC, Costello MJ. Distribution and type of morphological damage in human nuclear age-related cataracts. Exp Eye Res. 1996;62:237-251.
37. Costello MJ, Oliver TN, Cobo LM. Cellular architecture in age-related human nuclear cataracts. Invest Ophthalmol Vis Sci. 1992;33:3209-3227.
38. Gilliland KO, Freel CD, Johnsen S, Craig Fowler W, Costello MJ. Distribution, spherical structure and predicted Mie scattering of multilamellar bodies in human age-related nuclear cataracts. Exp Eye Res. 2004;79:563-576.