The influence of family structure, the TPH2 G-703T and the 5-HTTLPR serotonergic genes upon affective problems in children aged 10-14 years

Journal of Child Psychology and Psychiatry and Allied Disciplines

Volumn 50, Issue 3, 2009, Pages 317-325

  Nobile, Maria ^a   Rusconi, Marianna ^b   Bellina, Monica ^a   Marino, Cecilia ^a,c   Giorda, Roberto ^b   Carlet, Ombretta ^a   Vanzin, Laura ^a   Molteni, Massimo ^a   Battaglia, Marco ^a,c,d  

^a SCIENTIFIC INSTITUTE   (Italy)

^b Eugenio Medea'Scientific Institute   (Italy)

^c UNIVERSITÉ LAVAL   (Canada)

^d VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

Author keywords

Affective disorders; Children; Depression; Divorce; Family; Gene environment interaction; Serotonin

Indexed keywords

5HTTLPR GENE; ADOLESCENT; ALLELE; ARTICLE; CAUCASIAN; CHILD; CHILD BEHAVIOR CHECKLIST; DEPRESSION; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; EFFECT SIZE; ENVIRONMENTAL FACTOR; FAMILY; GENE; GENETIC LINKAGE; GENETIC POLYMORPHISM; HUMAN; ITALY; MAJOR CLINICAL STUDY; MOOD DISORDER; PROTEIN VARIANT; QUANTITATIVE GENETICS; RISK FACTOR; SCHOOL CHILD; SEROTONINERGIC SYSTEM; TPH2 GENE; FEMALE; GENETIC PREDISPOSITION; GENETICS; HOSPITALIZATION; MALE; PSYCHOLOGICAL ASPECT; PSYCHOLOGY; QUESTIONNAIRE;

SEROTONIN TRANSPORTER; SLC6A4 PROTEIN, HUMAN; TPH2 PROTEIN, HUMAN; TRYPTOPHAN HYDROXYLASE;

ADOLESCENT; CHILD; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MOOD DISORDERS; POLYMORPHISM, GENETIC; PSYCHOLOGY; QUESTIONNAIRES; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEVERITY OF ILLNESS INDEX; TRYPTOPHAN HYDROXYLASE;

EID: 68149132933     PISSN: 00219630     EISSN: 14697610     Source Type: Journal    
DOI: 10.1111/j.1469-7610.2008.01958.x     Document Type: Article

References (44)

1. Achenbach, T.M., & Rescorla, L.A. (2001). Manual for the ASEBA School-age Forms and Profiles. Burlington, VT: University of Vermont, Department of Psychiatry.
2. Battaglia, M., Pesenti-Gritti, P., Spatola, C.A.M., Ogliari, A., & Tambs, K. (2007). A twin study of the common vulnerability between heightened sensitivity to hypercapnia and panic disorder. American Journal of Medical Genetics - Neuro-Psychiatric Genetics [DOI:10.1002/ajmg.b.30647/ PMID: 18040986].
3. Bramlett, M.D., & Blumberg, S.J. (2007). Family structure and children's physical and mental health. Health Affairs, 26, 549-558.
4. Brown, S.M., Peet, E., Manuck, S.B., Williamson, D.E., Dahl, R.E., Ferrell, R.E., & Hariri, A.R. (2005). A regulatory variant of the human tryptophan hydroxylases gene biases amygdala reactivity. Molecular Psychiatry, 10, 884-888.
5. Caspi, A., Sugden, K., Moffitt, T.E., Taylor, A., Craig, I.W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., & Poulton, R. (2003). Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science, 301, 386-389.
6. Cuffe, S.P., McKeown, R.E., Addy, C.L., & Garrison, C.Z. (2005). Family and psychosocial risk factors in a longitudinal epidemiological study of adolescents. Journal of American Academy of Child and Adolescent Psychiatry, 44, 121-129.
7. D'Onofrio, B.M., Turkheimer, E., Emery, R.E., Maes, H.H., Silberg, J., & Eaves, L.J. (2007). A Children of Twins Study of parental divorce and offspring psychopathology. Journal of Child Psychology and Psychiatry, 48, 667-675.
8. D'Onofrio, B.M., Turkheimer, E., Emery, R.E., Slutske, W.S., Heath, A.C., Madden, P.A., & Martin, N.G. (2005). A genetically informed study of marital instability and its association with offspring psychopathology. Journal of Abnormal Psychology, 114, 570-586.
9. D'Onofrio, B.M., Turkheimer, E., Emery, R.E., Slutske, W.S., Heath, A.C., Madden, P.A., & Martin, N.G. (2006). A genetically informed study of the processes underlying the association between parental marital instability and offspring adjustment. Developmental Psychology, 42, 486-499.
10. Eaves, L.J. (2006). Genotype x environment interaction in psychopathology: Fact or artifact? Twin Research and Human Genetics, 9, 1-8.
11. Eaves, L., Silberg, J., & Erkanli, A. (2003). Resolving multiple epigenetic pathways to adolescent depression. Journal of Child Psychology and Psychiatry, 44, 1006-1014.
12. Eley, T.C., Sugden, K., Corsico, A., Gregory, A.M., Sham, P., McGuffin, P., Plomin, R., & Craig, I.W. (2004). Gene-environment interaction analysis of serotonin system markers with adolescent depression. Molecular Psychiatry, 9, 908-915.
13. Ferdinand, R.F. (2008). Validity of the CBCL/YSR DSMIV scales Anxiety Problems and Affective Problems. Journal of Anxiety Disorders, 22, 126-134.
14. Fergusson, D.M., Boden, J.M., & Horwood, L.J. (2007). Exposure to single parenthood in childhood and later mental health, educational, economic, and criminal behavior outcomes. Archives of General Psychiatry, 64, 1089-1095.
15. Frigerio, A., Cattaneo, C., Cataldo, M.G., Schiatti, A., Molteni, M., & Battaglia, M. (2004). Behavioral and emotional problems among Italian children and adolescents aged 4 to 18 years as reported by parents and teachers. European Journal of Psychological Assessment, 20, 124-133.
16. Frigerio, A., Vanzin, L., Pastore, V., Nobile, M., Giorda, R., Marino, C., et al. (2006). The Italian préadolescent mental health project (PrISMA): Rationale and methods. International Journal of Methods in Psychiatric Research, 15, 22-35.
17. Gutknecht, L., Jacob, C., Strobel, A., Kriegebaum, C., Muller, J., et al. (2007). Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation. International Journal of Neuropsychopharmacolagy, 10, 309-320.
18. Herrmann, M.J., Huter, T., Müller, F., Mühlberger, A., Pauli, P., Reif, A., Renner, T., Canli, T., Fallgatter, A.J., & Lesch, K.P. (2007). Additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on emotional processing. Cerebral Cortex, 17, 1160-1163.
19. Hetherington, E.M., Bridges, M., & Insabella, G.M. (1998). What matters? What does not? Five perspectives on the association between marital transitions and children's adjustment. American Psychologist, 53, 167-184.
20. Hu, X.Z., Lipsky, R.H., Zhu, G., Akhtar, L.A., Taubman, J., Greenberg, B.D., Xu, K., Arnold, P.D., Richter, M.A., Kennedy, J.L., Murphy, D.L., & Goldman, D. (2006). Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. American Journal of Human Genetics, 78, 815-826.
21. ISTAT. (2006). Rapporto annuale 2005. Roma: Istituto Nazionale di Statistica. Available from http://www. istat.it/dati/catalogo/20060524-00/.
22. Jaffee, S.R., Moffitt, T.E., Caspi, A., Fombonne, E., Poulton, R., & Martin, J. (2002). Differences in early childhood risk factors for juvenile-onset and adultonset depression. Archives of General Psychiatry, 59, 215-222.
23. Kaufman, J., Yang, B.Z., Douglas-Palumberi, H., Houshyar, S., Lipschitz, D., Krystal, J.H., & Gelernter, J. (2004). Social supports and serotonin transporter gene moderate depression in maltreated children. Proceedings of the National Academy of Sciences of the USA, 101, 17316-17321.
24. Lau, J.Y., & Eley, T.C. (2008). Disentangling gene-environment correlations and interactions on adolescent depressive symptoms. Journal of Child Psychology and Psychiatry, 49, 142-150.
25. Lesch, K.P. (2003). Neuroticism and serotonin: A developmental genetic perspective. In R. Plomin, J.C DeFries, I.W. Craig, & P. McGuffin (Eds.), Behavioral genetics in postgenomic era (pp. 389-423). Washington, DC: American Psychological Association.
26. Lesch, K.P., Bengel, D., Heils, A., Sabol, S.Z., Greenberg, B.D., Petri, S., Benjamin, J., Muller, C.R., Hamer, D.H., & Murphy, D.L. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274, 1527-1531.
27. Luby, J.L., Beiden, A.C., & Spitznagel, E. (2006). Risk factors for preschool depression: The mediating role of early stressful life events. Journal of Child Psychology and Psychiatry, 47, 1292-1298.
28. Meltzer, H., Gatward, R., Corbin, T., Goodman, R., & Ford, T. (2003). Persistence, onset, risk factors and outcomes of childhood mental disorders. London: Office for National Statistics.
29. Moffitt, T.E., Caspi, A., & Rutter, M. (2006). Measured gene-environment interactions in psychopathology. Perspectives on Psychological Science, 1, 5-27.
30. Munafo, M.R., Clark, T.G., Moore, L.R., Payne, E., Walton, R., & Flint, J. (2003). Genetic polymorphisms and personality in healthy adults: A systematic review and meta-analysis. Molecular Psychiatry, 8, 471-484.
31. Neuman, R.J., Geller, B., Rice, J.P., & Todd, R.D. (1997). Increased prevalence and earlier onset of mood disorders among relatives of prepubertal versus adult probands. Journal of American Academy of Child and Adolescent Psychiatry, 36, 466-473.
32. Nobile, M., Begni, B., Giorda, R., Frigerio, A., Marino, C., et al. (1999). Effects of serotonin transporter promoter genotype on platelet serotonin transporter functionality in depressed children and adolescents. Journal of the American Academy of Child and Adolescent Psychiatry, 38, 1396-1402.
33. Nobile, M., Giorda, R., Marino, C., Carlet, O., Pastore, V., Vanzin, L., Bellina, M., Molteni, M., & Battaglia, M. (2007). Socioeconomic status mediates the genetic contribution of the DRD4 and 5-HTTLPR polymorphisms to externalization in pre-adolescence. Development and Psychopathology, 19, 1145-1158.
34. O'Connor, T.G., Caspi, A., DeFries, J.C., & Plomin, R. (2000). Are associations between parental divorce and children's adjustment genetically mediated? An adoption study. Developmental Psychology, 36, 429-1137
35. O'Connor, T.G., Caspi, A., Denies, J.C., & Plomin, R. (2003). Genotype-environment interaction in children's adjustment to parental separation. Journal of Child Psychology and Psychiatry, 44, 849-856.
36. O'Connor, T.G., Dunn, J., Jenkins, J.M., Pickering, K., & Rasbash, J. (2001). Family settings and children's adjustment: Differential adjustment within and across families. British Journal of Psychiatry, 179, 110-115.
37. Rutter, M. (2005). Environmentally mediated risks for psychopathology: Research strategies and findings. Journal of the American Academy of Child and Adolescent Psychiatry, 44, 3-18.
38. Rutter, M., Moffitt, T.E., & Caspi, A. (2006). Geneenvironment interplay and psychopathology: Multiple varieties but real effects. Journal of Child Psychology and Psychiatry, 47, 226-261.
39. Scheuch, K., Lautenschlager, M., Grohmann, M., Stahlberg, S., Kirchheiner, J., Zill, P., Heinz, A., Walther, D.J., & Priller, J. (2007). Characterization of a functional promoter polymorphism of the human tryptophan hydroxylase 2 gene in serotonergic raphe neurons. Biological Psychiatry, 62, 1288-1294.
40. Spatola, C.A., Fagnani, C., Pesenti-Gritti, P., Ogliari, A., Stazi, M.A., & Battaglia, M. (2007). A general population twin study of the CBCL/6-18 DSM-oriented scales. Journal of the American Academy of Child and Adolescent Psychiatry, 46, 619-627.
41. Thapar, A., & McGuffin, P. (1994). A twin study of depressive symptoms in childhood. British Journal of Psychiatry, 165, 259-265.
42. Zammit, S., & Owen, M.J. (2006). Stressful life events, 5-HTT genotype and risk of depression. The British Journal of Psychiatry, 188, 199-201.
43. Zhang, X., Beaulieu, J.M., Gainetdinov, R.R., & Caron, M.G. (2006). Functional polymorphisms of the brain serotonin synthesizing enzyme tryptophan hydroxylases. Cellular and Molecular Life Sciences, 63, 6-11.
44. Zhou, Z., Roy, A., Lipsky, R., Kuchipudi, K., Zhu, G., Taubman, J., Enoch, M.A., Virkkunen, M., & Goldman, D. (2005). Haplotype-based linkage of tryptophan hydroxylase 2 to suicide attempt, major depression, and cerebrospinal fluid 5-Hydroxyindoleacetic Acid in 4 populations. Archives of General Psychiatry, 62, 1109-1118.