Association between 5-HTTLPR genotypes and persisting patterns of anxiety and alcohol use: Results from a 10-year longitudinal study of adolescent mental health

Molecular Psychiatry

Volumn 10, Issue 9, 2005, Pages 868-876

  Olsson, C A ^a,b   Byrnes, G B ^a   Lotfi Miri, M ^a   Collins, V ^a   Williamson, R ^a   Patton, C ^a   Anney, R J L ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b ROYAL CHILDREN'S HOSPITAL   (Australia)

Author keywords

5 HTTLPR; Adolescence; Alcohol; Anxiety; Gene environment interaction

Indexed keywords

ALCOHOL; SEROTONIN TRANSPORTER; CARRIER PROTEIN; MEMBRANE PROTEIN; NERVE PROTEIN; SLC6A4 PROTEIN, HUMAN;

ADOLESCENCE; ALCOHOL CONSUMPTION; ALCOHOLISM; ALLELE; ANXIETY DISORDER; ARTICLE; AUSTRALIA; BINGE EATING DISORDER; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL HEALTH; PRIORITY JOURNAL; ADOLESCENT; ADULT; ANXIETY; CHILD PSYCHOLOGY; DRINKING BEHAVIOR; FOLLOW UP; GENETICS; LONGITUDINAL STUDY; PATHOPHYSIOLOGY; SEXUAL DEVELOPMENT;

ADOLESCENT; ADOLESCENT PSYCHOLOGY; ADULT; ALCOHOL DRINKING; ANXIETY; COHORT STUDIES; FEMALE; FOLLOW-UP STUDIES; GENOTYPE; HUMANS; LONGITUDINAL STUDIES; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEX CHARACTERISTICS;

EID: 27744588449     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/sj.mp.4001677     Document Type: Article

References (53)

1. Lesch KP, Meyer J, Glatz K, Flugge G, Hinney A, Hebebrand J et al. The 5-HT transporter gene-linked polymorphic region (5-HTTLPR) in evolutionary perspective: alternative biallelic variation in rhesus monkeys. J Neur Transm 1997; 104: 1259-1266.
2. Heils A, Teufel A, Petri S, Stober G, Riederer P, Bengel D et al. Allelic variation of human serotonin transporter gene expression. J Neurochem 1996; 66: 2621-2624.
3. Ueno S. Genetic polymorphisms of serotonin and dopamine transporters in mental disorders (review). J Med Invest 2003; 50: 25-31.
4. Ramamoorthy S, Cool DR, Mahesh VB, Leiback FH, Melikian HE, Blakey RD et al. Regulation of the human serotonin transporter: cholera toxin-induced stimulation of serotonin uptake in human placental choriocarcinoma cells is accompanied by increased serotonin transporter mRNA levels and serotonin transporter-specific ligand binding. J Biol Chem 1993; 268: 21626-21631.
5. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996; 274: 1527-1531.
6. Cavallini MC, Di Bella D, Siliprandi F, Bellodi L. Exploratory factor analysis of obsessive-compulsive patients and association with 5-HTTLPR polymorphism. Am J Med Genet 2002; 114: 347-353.
7. Osher Y, Hamer D, Benjamin J. Association and linkage of anxiety-related traits with a functional polymorphism of the serotonin transporter gene regulatory region in Israeli sibling pairs. Mol Psychiatry 2000; 5: 216-219.
8. Young SE, Smolen A, Stallings MC, Corley RP, Hewitt JK. Sibling-based association analyses of the serotonin transporter polymorphism and internalizing behaviour problems in children. J Child Psychol Psychiatry 2003; 44: 961-967.
9. Jorm AF, Prior M, Sanson A, Smart D, Zhang Y, Easteal S. Association of a functional polymorphism of the serotonin transporter gene with anxiety-related temperament and behaviour problems in children: a longitudinal study from infancy to the mid-teens. Mol Psychiatry 2000; 5: 542-547.
10. Stein MB, Chartier MJ, Kozak MV, King N, Kennedy JL. Genetic linkage to the serotonin transporter protein and 5HT2A receptor genes excluded in generalized social phobia. Psychiatry Res 1998; 81: 283-291.
11. Ball D, Hill L, Freeman B, Eley TC, Strelau J, Riemann R et al. The serotonin transporter gene and peer-rated neuroticism. Neuroreport 1997; 8: 1301-1304.
12. Kent L, Doerry U, Hardy E, Parmar R, Gingell K, Hawi Z et al. Evidence that variation at the serotonin transporter gene influences susceptibility to attention deficit hyperactivity disorder (ADHD): analysis and pooled analysis. Mol Psychiatry 2002; 7: 908-912.
13. Johann M, Bobbe G, Putzhammer A, Wodarz N. Co-morbidity of alcohol dependence with attention deficit hyperactivity disorder: difference in phenotype with increased severity of the substance disorder, but not in genotype (serotonin transporter and 5 hydroxytryptamine-2c receptor). Alcohol Clin Exp Res 2003; 27: 1527-1534.
14. Langley K, Payton A, Hamshere ML, Pay HM, Lawson DC, Turic D et al. No evidence of association of two 5HT transporter gene polymorphisms and attention deficit hyperactivity disorder. Psychiatr Genet 2003; 13: 107-110.
15. Zoroglu SS, Erdal ME, Alasehirli B, Erdal N, Sivasli E, Tutken H et al. Significance of serotonin transporter gene 5-HTTLPR and variable number tandem repeat polymorphism in attention deficit hyperactivity disorder. Neuropsychobiology 2002; 45: 176-181.
16. Lauzurica N, Hurtado A, Escarti A, Delgado M, Barrios V, Morande G et al. Polymorphisms within the promoter and the intron 2 of the serotonin transporter gene in a population of bulimic patients. Neurosci Let 2003; 352: 226-230.
17. Sundaramurthy D, Pieri LF, Gape H, Markham AF, Campbell DA. Analysis of the serotonin transporter gene linked polymorphism (5-HTTLPR) in anorexia nervosa. Am J Med Genet 2000; 96: 53-55.
18. Hinney A, Barth N, Ziegler A, von Prittwitz S, Hamann A, Hennighausen K et al. Serotonin transporter gene-linked polymorphic region: allele distributions in relationship to body weight and in anorexia nervosa. Life Sci 1997; 61: 295-303.
19. Cadoret RJ, Langbehn D, Caspers K, Troughton EP, Yucuis R, Sandhu HK et al. Associations of the serotonin transporter promoter polymorphism with aggressivity, attention deficit, and conduct disorder in an adoptee population. Compr Psychiatry 2003; 44: 88-101.
20. Patkar AA, Berrettini WH, Hoehe M, Thornton CC, Gottheil E, Hill K et al. Serotonin transporter polymorphisms and measures of impulsivity, aggression, and sensation seeking among African-American cocaine-dependent individuals. Psychiatry Res 2002; 110: 103-115.
21. Golimbet VE, Alfimova MV, Shcherbatykh TV, Rogaev EI. Gene insertion and deletion polymorphism in the serotonin transporter gene and personality traits measured by MMPI. Genetika 2003; 39: 534-539.
22. Kaiser R, Tremblay PB, Schmider J, Henneken M, Dettling M, Muller-Oerlinghausen B et al. Serotonin transporter polymorphisms: no association with response to antipsychotic treatment, but associations with the schizoparanoid and residual subtypes of schizophrenia. Mol Psychiatry 2001; 6: 179-185.
23. Serretti A, Cusin C, Lattuada E, Lilli R, Lorenzi C, De Bella D et al. No interaction between serotonin transporter gene and dopamine receptor D4 gene in symptomatology of major psychoses. Am J Med Genet 1999; 88: 481-485.
24. Stober G, Jatzke S, Heils A, Jungkunz G, Fuchs E, Knapp M et al. Susceptibility for schizophrenia is not influenced by a functional insertion/deletion variant in the promoter of the serotonin transporter gene. Eur Arch Psychiatr Clin Neurosci 1998; 248: 82-86.
25. Bellivier F, Leroux M, Henry C, Rayah F, Rouillon F, Laplanche JL et al. Serotonin transporter gene polymorphism influences age at onset in patients with bipolar affective disorder. Neurosci Lett 2002; 334: 17-20.
26. Geller B, Cook Jr EH. Serotonin transporter gene (HTTLPR) is not in linkage disequilibrium with pre-pubertal and early adolescent bipolarity. Biol Psychiatry 1999; 45: 1230-1233.
27. Furlong RA, Ho L, Walsh C, Rubinsztein S, Jain S, Paykel ES et al. Analysis and meta-analysis of two serotonin transporter gene polymorphisms in bipolar and unipolar affective disorders. Am J Medical Genet 1998; 81: 58-63.
28. Gutierrez B, Arranz MJ, Collier DA, Valles V, Guillamat R, Bertranpetit J et al. Serotonin transporter gene and risk for bipolar affective disorder: an association study in Spanish population. Biol Psychiatry 1998; 43: 843-847.
29. Kim SJ, Cox N, Courchesne R, Lord C, Corsello C, Akshoomoff N et al. Transmission disequilibrium mapping at the serotonin transporter gene (SLC6A4) region in autistic disorder. Mol Psychiatry 2002; 7: 278-288.
30. Tordjman S, Gutknecht L, Carlier M, Spitz E, Antoine C, Slama F et al. Role of serotonin transporter gene in the behaviour expression of autism. Mol Psychiatry 2001; 6: 434-439.
31. Betancur C, Corbex M, Spielewoy C, Philippe A, Laplanche JL, Launay JM et al. Serotonin transporter gene polymorphisms and hyperserotonemia in autistic disorder. Mol Psychiatry 2002; 7: 67-71.
32. Persico AM, Militerni R, Bravaccio C, Schneider C, Melmed R, Conciatori M et al. Lack of association between serotonin transporter gene promoter variants and autistic disorder in two ethnically distinct samples. Am J Med Genet 2000; 96: 123-127.
33. Cook Jr EH, Courchesne R, Lord C, Cox NJ, Yan S, Lincoln A et al. Evidence of linkage between the serotonin transporter and autistic disorder. Mol Psychiatry 1997; 2: 247-250.
34. Barr CS, Newman TK, Becker ML, Parker CC, Champoux M, Lesch KP et al. The utility of the non-human primate model for studying gene by environment interactions in behavioral research. Genes Brain Behav 2003; 2: 336-340.
35. Caspi A, McLay J, Moffitt TE, Mill J, Marin J, Craig IW et al. Role of genotype in the cycle of violence in maltreated children. Science 2002; 297: 851-854.
36. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 2003; 301: 386-389.
37. Dwyer T, Ponsonby AL, Stankovich J, Blizzard L, Easteal S. Measuring environmental factors can enhance the search for disease causing genes? J Epidemiol Community Health 2004; 58: 613-615.
38. Bennet AJ, Lesch KP, Heils A, Long JC, Lorenz JG, Shoaf SE et al. Early experience and serotonin transporter gene variation interact to influence primate CNS function. Mol Psychiatry 2002; 7: 118-122.
39. Bennet AJ, Lesch KP, Heils A, Linnoila MV. Serotonin transporter genetic variation, CSF 5-HIAA concentrations, and alcohol-related aggression in rhesus monkeys (Macaca mulatta). Am J Primatol 1998; 45: 168-169.
40. Suomi SJ. How gene-environment interactions can shape the development of socioemotional regulation in rhesus monkeys. In: Zuckerman BS, Lieberman AF, Fox NA (eds) Emotional Regulation and Developmental Health: Infancy and Early Childhood. Johnson & Johnson Pediatric Institute (LLC), Calverton, NY, 2002, pp 5-26.
41. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig I, Harrington H et al. Influence of life stress on depression: moderation by polymorphism in the 5-HTT gene. Science 2003; 301: 386-389.
42. Manuck SB, Flory JD, Ferrell RE, Muldoon MF. Socio-economic status covaries with central nervous system serotonergic responsivity as a function of allelic variation in the serotonin transporter gene-linked polymorphic region. Psychoneuroendocrinology 2004; 29: 651-668.
43. Bowlby J. Attachment and Loss: Vol 1. Attachment. Basic Books: New York, 1969.
44. Bowlby J. Attachment and Loss: Vol 2. Separation: Anxiety and Anger. Basic Books: New York, 1973.
45. Bowlby J. Attachment and Loss: Vol 3. Loss. Basic Books: New York, 1980.
46. Hazan C, Shaver P. Romantic love conceptualized as an attachment process. J Pers Soc Psychol 1987; 52: 511-524.
47. Ainsworth MDS, Blehar MC, Waters E, Wall S. Patterns of Attachment: A Psychological Study of the Strange Situation. Erlbaum: Hillsdale, NJ, 1978.
48. Paperny DM, Aono JY, Lehman RM, Hammar SL, Risser J. Computer-assisted detection and intervention in adolescent high-risk health behaviours. J Paediatr 1990; 116: 456-462.
49. Lewis G, Pelosi AJ, Glover E, Wilkinson G, Stansfeld SA, Williams P et al. The development of a computerised assessment for minor psychiatric disorder. Psychol Med 1988; 18: 737-745.
50. Gelernter J, Kranzler H, Cubells JF. Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjects. Hum Genet 1997; 101: 243-246.
51. Sterne JAC, Davey Smith G. Shifting the evidence - what is wrong with significance testing? BMJ 2001; 322: 226-231.
52. Herman AI, Philbeck JW, Vasilopoulos NL, Depetrillo PB. Serotonin transporter promoter polymorphism and differences in alcohol consumption behaviour in a college student population. Alcohol Alcohol 2003; 38: 446-449.
53. Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW et al. Role of genotype in the cycle of violence in maltreated children. Science 2002; 297: 851-854.