Life events, first depression onset and the serotonin transporter gene

British Journal of Psychiatry

Volumn 188, Issue MAR., 2006, Pages 210-215

  Wilhelm, Kay ^a,d   Mitchell, Philip B ^a   Niven, Heather ^a   Finch, Adam ^a   Wedgwood, Lucinda ^a   Scimone, Anna ^b   Blair, Ian P ^b   Parker, Gordon ^a   Schofield, Peter R ^b,c  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c NEUROSCIENCE RESEARCH AUSTRALIA   (Australia)

^d ST VINCENT S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

SEROTONIN TRANSPORTER;

ADULT; ARTICLE; AUSTRALIA; CHILD PARENT RELATION; COHORT ANALYSIS; DEPRESSION; EXPERIENCE; FAMILY LIFE; FEMALE; GENE; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE; HUMAN; LIFE EVENT; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; NEUROSIS; ONSET AGE; PREDICTION; RISK ASSESSMENT; RISK FACTOR; SEROTONIN TRANSPORTER GENE;

ADULT; DEPRESSIVE DISORDER, MAJOR; FEMALE; FOLLOW-UP STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; LIFE CHANGE EVENTS; LOGISTIC MODELS; MALE; NEUROTIC DISORDERS; OBJECT ATTACHMENT; PARENT-CHILD RELATIONS; RISK FACTORS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEX FACTORS;

EID: 33644753812     PISSN: 00071250     EISSN: None     Source Type: Journal    
DOI: 10.1192/bjp.bp.105.009522     Document Type: Article

References (36)

1. Anguelova, M., Benkelfat, C. & Turecki, G. (2003) A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter. I. Affective disorders. Molecular Psychiatry, 8, 574-591.
2. Caspi, A., Sugden, K., Moffitt, T., et al (2003) Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science, 301, 386-389.
3. Costello, C. & Comrey, A. (1967) Scales for measuring depression and anxiety. Journal of Psychology, 66, 303-313.
4. Deary, I., Battersby, S., Whiteman, M., et al (1999) Neuroticism and polymorphisms in the serotonin transporter gene. Psychological Medicine, 29, 735-739.
5. Eccleston, D. & Scott, J. (1991) Treatment, prediction of relapse and prognosis of chronic primary major depression. International Journal of Clinical Psychopharmacology, 6, 3-9.
6. Eley, T., Sugden, K., Corsico, A., et al (2004) Gene-environment interaction analysis of serotonin system markers with adolescent depression. Molecular Psychiatry, 9, 908-915.
7. Eysenck, H. & Eysenck, S. (1964) Manual of the Eysenck Personality Inventory. London: Hodder and Stoughton.
8. Farmer, A. & Owen, M. (1996) Genomics: the next psychiatric revolution? British Journal of Psychiatry, 169, 135-138.
9. Farmer, A., Eley, T. C. & McGuffin, P. (2005) Current strategies for investigating the genetic and environmental risk factors for affective disorders. British Journal of Psychiatry, 186, 179-181.
10. Gillespie, N. A., Whitfield, J. B., Williams, B., et al (2004) The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression. Psychological Medicine, 34, 1-11.
11. Grabe, H. J., Lange, M., Wolff, B., et al (2005) Mental and physical distress is modulated by a polymorphism in the 5-HT transporter gene interacting with social stressors and chronic disease burden. Molecular Psychiatry, 10, 220-224.
12. Greenberg, B. D., Li, Q., Lucas, F. R., et al (2000) Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample. American Journal of Medical Genetics, 96, 202-216.
13. Hankin, B., Abramson, L., Moffitt, T., et al (1998) Development of depression from pre-adolescence to young adulthood: emerging gender differences in a 10-year longitudinal study. Journal of Abnormal Psychology, 107, 128-140.
14. Jorm, A., Henderson, A., Jacomb, P., et al (1998) An association study of a functional polymorphism of the serotonin transporter gene with personality and psychiatric symptoms. Molecular Psychiatry, 3, 449-451.
15. Kaufman, J., Yang, B. Z., Douglas-Palumberi, H., et al (2004) Social supports and serotonin transporter gene moderate depression in maltreated children. Proceedings of the National Academy of Sciences of the United States of America, 10, 17316-17321.
16. Kendler, K. S., Karkowski, L. M. & Prescott, C. A. (1999) Causal relationship between stressful life events and the onset of major depression. American Journal of Psychiatry, 156, 837-848.
17. Kendler, K. S., Kuhn, J. & Prescott, C. A. (2004) The interrelationship of neuroticism, sex, and stressful life events in the prediction of episodes of major depression. American Journal of Psychiatry, 161, 631-636.
18. Lesch, K. P., Bengel, D., Heils, A., et al (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274, 1527-1531.
19. Loehlin, J. (1992) Genes and Environment in Personality Development. Newbury Park, CA: Sage.
20. Miller, S. A., Dykes, D. D. & Polesky, H. F. (1988) A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Research, 16, 1215.
21. Morley, K., Hall, W. & Carter, L. (2004) Genetic screening for susceptibility to depression: can we and should we? Australian and New Zealand Journal of Psychiatry, 38, 73-80.
22. Parker, G., Tupling, H. & Brown, L. (1979) A parental bonding instrument. British Journal of Medical Psychology, 52, 1-10.
23. Parker, G., Wilhelm, K. & Asghari, A. (1998) Depressed mood states and their interrelationship with clinical depression. Social Psychiatry and Psychiatric Epidemiology, 33, 10-15.
24. Robins, L. & Helzer, J. (1988) New diagnostic instruments. In Handbook of Social Psychiatry (ed. G. Burrows), pp. 3-12. Sydney: Elsevier.
25. Robins, L., Helzer, J., Croughan, J., et al (1981) National Institute of Mental Health Diagnostic Interview Schedule: its history, characteristics and validity. Archives of General Psychiatry, 38, 381-389.
26. Rutter, M. & Plomin, R. (1997) Opportunities for psychiatry from genetic findings. British Journal of Psychiatry, 171, 209-219.
27. Schinka, J., Busch, R. & Robichaux-Keene, N. (2004) A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety. Molecular Psychiatry, 9, 197-202.
28. Thompson, R., Bogner, H. R., Coyne, J. C., et al (2004) Personal characteristics associated with consistency of recall of depressed or anhedonic mood in the 13-year follow-up of the Baltimore Epidemiologic Catchment Area Survey. Acta Psychiatrica Scandinavica, 109, 345-354.
29. Weissman, M. M., Bland, R. C., Canino, G. J., et al (1996) Cross-national epidemiology of major depression and bipolar disorder. JAMA. 276, 293-299.
30. Wells, J. & Horwood, L. (2004) How accurate is recall of key symptoms of depression? A comparison of recall and longitudinal reports. Psychological Medicine, 34, 1001-1011.
31. Wilhelm, K. & Parker, G. (1989) Is sex necessarily a risk factor to depression? Psychological Medicine, 19, 401-413.
32. Wilhelm, K. & Parker, G. (1993) Sex differences in depressogenic risk factors and coping strategies in a socially homogeneous group. Acta Psychiatrica Scandinavica, 88, 205-211.
33. Wilhelm, K. & Parker, G. (1994) Sex differences in lifetime depression rates: fact or artefact? Psychological Medicine, 24, 97-111.
34. Wilhelm, K., Parker, G. & Hadzi-Pavlovic, D. (1997) Fifteen years on: evolving ideas on researching sex differences in depression. Psychological Medicine, 27, 875-883.
35. Wilhelm, K., Parker, G. & Asghari, A. (1998) Sex differences in the experience of depressed mood state over 15 years. Social Psychiatry and Psychiatric Epidemiology, 33, 16-20.
36. Wilhelm, K., Parker, G., Dewhurst-Savellis, J., et al (1999) Psychological predictors of single and recurrent major depressive episodes. Journal of Affective Disorders, 54, 139-147.