Cyclosporin A differentially inhibits multiple steps in VEGF induced angiogenesis in human microvascular endothelial cells through altered intracellular signaling

Cell Communication and Signaling

Volumn 2, Issue , 2004, Pages

  Rafiee, Parvaneh ^a,b   Heidemann, Jan ^a   Ogawa, Hitoshi ^a   Johnson, Nathan A ^b   Fisher, Pamela J ^a   Li, Mona S ^a   Otterson, Mary F ^a,c   Johnson, Christopher P ^a   Binion, David G ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b CHILDREN S HOSPITAL OF WISCONSIN   (United States)

^c CLEMENT J ZABLOCKI VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; CYCLOSPORIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P42; PROTEIN P44; TRANSCRIPTION FACTOR NFAT; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; CELL CULTURE; CELL MIGRATION; CELL NUCLEUS; CELL PROLIFERATION; CELL STIMULATION; CHRONIC GRAFT REJECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENDOTHELIUM CELL; GASTROINTESTINAL TRACT; HOMEOSTASIS; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR TRANSPORT; MICROVASCULARIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STRESS FIBER; VASCULAR DISEASE; VASCULAR ENDOTHELIUM;

EID: 33751562062     PISSN: 1478811X     EISSN: None     Source Type: Journal    
DOI: 10.1186/1478-811X-2-3     Document Type: Article

References (54)

1. Goldfeld AE, Tsai E, Kincaid R, Belshaw PJ, Schrieber SL, Strominger JL, Rao A: Calcineurin mediates human tumor necrosis factor alpha gene induction in stimulated T and B cells. J Exp Med 1994, 180:763-768.
2. Gao SZ, Schroeder JS, Alderman EL, Hunt SA, Valantine HA, Wiederhold V, Stinson EB: Prevalence of accelerated coronary artery disease in heart transplant survivors. Comparison of cyclosporine and azathioprine regimens. Circulation 1989, 80(Pt 2): 100-105.
3. Textor SC, Canzanello VJ, Taler SJ, Wilson DJ, Schwartz LL, Augustine JE, Raymer JM, Romero JC, Wiesner RH, Krom RA, Burnett J: Cyclosporine-induced hypertension after transplantation. Mayo Clin Proc 1994, 69:1182-1193.
4. Ventura HO, Malik FS, Mehra MR, Stapleton DD, Smart FW: Mechanisms of hypertension in cardiac transplantation and the role of cyclosporine. Curr Opin Cardiol 1997, 12:375-381.
5. Shears LL, Kawaharada N, Tzeng E, Billiar TR, Watkins SC, Kovesdi I, Lizonova A, Pham SM: Inducible nitric oxide synthase suppresses the development of allograft arteriosclerosis. J Clin Invest 1997, 100:2035-2042.
6. Klaus A, Margreiter R, Pernthaler H, Klima G, Offner FA: Diffuse mesenterial sclerosis: a characteristic feature of chronic small-bowel allograft rejection. Virchows Arch 2003, 442:48-55.
7. Parizhskaya M, Redondo C, Demetris A, Jaffe R, Reyes J, Ruppert K, Martin L, Abu-Elmagd K: Chronic rejection of small bowel grafts: pediatric and adult study of risk factors and morphologic progression. Pediatr Dev Pathol 2003, 6:240-250.
8. Medawar PB: Transplantation of tissues and organs: introduction. Br Med Bull 1965, 21:97-99.
9. Lagaaij EL, Cramer-Knijnenburg GF, van Kemenade FJ, van Es LA, Bruijn JA, van Krieken JH: Endothelial cell chimerism after renal transplantation and vascular rejection. Lancet 2001, 357:33-37.
10. Hruban RH, Beschrner WE, Baumgartner WA, Augustine SM, Ren H, Reitz BA, Hutchins GM: Accelerated arteriosclerosis in heart transplant recipients is associated with a T-lymphocyte-mediated endothelialitis. Am J Pathol 1990, 137:871-882.
11. Taylor PM, Rose ML, Yacoub MH, Pigott R: Induction of vascular adhesion molecules during rejection of human cardiac allografts. Transplantation 1992, 54:451-457.
12. Brockmeyer C, Schendel DJ, Weiss EH, Hillebrand G, Burkhardt K, Land W, Gokel MJ, Riethmuller G, Feucht HE: Distribution of cell adhesion molecules (ICAM-1, VCAM-1, ELAM-1) in renal tissue during allograft rejection. Transplantation 1993, 55:610-615.
13. Rose ML: Endothelial as antigen-presenting cells: role in human transplant rejection. Cell Mol Life Sci 1998, 54:965-978.
14. Salcedo R, Resau JH, Halverson D, Hudson EA, Dambach M, Powell D, Wasserman K, Oppenheim JJ: Differential expression and responsiveness of chemokine receptors (CXCRI-3) by human microvascular endothelial cells and umbilical vein endothelial cells. FASEB J 2000, 14:2055-2064.
15. Auerbach R, Lewis R, Shinners B, Kubai L, Akhtar N: Angiogenesis assays: a critical overview. Clin Chem 2003, 49:32-40.
16. Takahashi M, Matsui A, Inao M, Mochida S, Fujiwara K: ERK/MAPK-dependent P13K/Akt phosphorylation through VEGFR-1 after VEGF stimulation in activated hepatic stellate cells. Hepatol Res 2003, 26:232-236.
17. Huot J, Houle F, Rousseau S, Deschesnes RG, Shah GM, Landry J: SAPK2/ p38-dependent F-actin reorganization regulates early membrane blebbing during stress-induced apoptosis.J Cell Biol 1998, 143:1361-1373.
18. Tamura M, Sebastian S, Yang S, Gurates B, Fang Z, Okamura K, Bulun SE: Induction of cyclooxygenase-2 in human endometrial stromal cells by malignant endometrial epithelial cells: evidence for the involvement of extracellularly regulated kinases and CCAAT/enhancer binding proteins. J Mol Endocrinol 2003, 31:95-104.
19. Shariat SF, Matsumoto K, Kim J, Ayala GE, Zhou JH, Jian W, Benedict WF, Lerner SP: Correlation of cyclooxygenase-2 expression with molecular markers, pathological features and clinical outcome of transitional cell carcinoma of the bladder. J Urol 2003, 170:985-989.
20. De Leng WW, Westerman AM, Weterman MA, De Rooij FW, Dekken Hv H, De Goeij AF, Gruber SB, Wilson JH, Offerhaus GJ, Giardiello FM, Keller JJ: Cyclooxygenase 2 expression and molecular alterations in Peutz-Jeghers hamartomas and carcinomas. Clin Cancer Res 2003, 9:3065-3072.
21. Armesilla AL, Lorenzo E, Gomez del Arco P, Martinez-Martinez S, Alfranca A, Redondo JM: Vascular Endothelial Growth Factor Activates Nuclear Factor of Activated T-Cells in Human Endothelial Cells: a Role for Tissue Factor Gene Expression. Mol Cell Biol 1999, 19:2032-2043.
22. Hernandez GL, Volpert O, Iniguez MA, Lorenzo E, Martinez-Martinez S, Grau R, Fresno M, Redondo JM: Selective inhibition of vascular endothelial growth factor-mediated angiogenesis by cyclosporin A: roles of the nuclear factor of activated T cells and cyclooxygenase 2. J Exp Med 2001, 193:607-620.
23. Wagner L, Hoey J, Erdely A, Boegehold MA, Baylis C: The nitric oxide pathway is amplified in venular vs arteriolar cultured rat mesenteric endothelial cells. Microvasc Res 2001, 62:401-409.
24. Mason JC, Yarwood H, Sugars K, Haskard DO: Human umbilical vein and dermal microvascular endothelial cells show heterogeneity in response to PKC activation. Am J Physiol 1997, 273:c1233-c1240.
25. Garlanda C, Dejana E: Heterogeneity of endothelial cells. Specific markers. Atheroscler Thromb Vasc Biol 1997, 17:1193-1102.
26. Petzelbauer P, Bender JR, Wilson J, Pober JS: Heterogeneity of dermal microvascular endothelial cell antigen expression and cytokine responsiveness in situ and in cell culture. J Immunol 1993, 151:5062-5072.
27. Page C, Rose M, Yacoub M, Pigott R: Antigenic heterogeneity of vascular endothelium. Am J Pathol 1992, 141:673-683.
28. Binion DG, West GA, Ina K, Ziats NP, Emancipator SN, Fiocchi C: Enhanced leukocyte binding by intestinal microvascular endothelial cells in inflammatory bowel disease. Gastroenterology 1997, 112:1895-1807.
29. Heidemann J, Ogawa H, Dwinell MB, Rafiee P, Maaser C, Gockel HR, Otterson MF, Ota DM, Lugering N, Domschke W, Binion DG: Angiogenic effects of interleukin 8 (CXCL8) in human intestinal microvascular endothelial cells are mediated by CXCR2. J Biol Chem 2003, 278:8508-8515.
30. Rafiee P, Johnson CP, Li MS, Ogawa H, Heidemann J, Fisher PJ, Lamirand TH, Otterson MF, Wilson KT, Binion DG: Cyclosporine A enhances leukocyte binding by human intestinal microvascular endothelial cells through inhibition of p38 MAPK and iNOS. Paradoxical proinflammatory effect on the microvascular endothelium. J Biol Chem 2002, 277:35605-35615.
31. Carmeliet P: Mechanisms of angiogenesis and arteriogenesis. Nat Med 2000, 6:389-397.
32. Tibbles LA, Woodgett JR: The stress-activated protein kinase pathways. Cell Mol Life Sci 1999, 55:1230-1254.
33. Rousseau S, Houle F, Kotanides H, Witte L, Waltenberger J, Landry J, Huot J: Vascular endothelial growth factor (VEGF)-driven actin-based motility is mediated by VEGFR2 and requires concerted activation of stress-activated protein kinase 2 (SAPK2/p38) and geldanamycin-sensitive phosphorylation of focal adhesion kinase. J Biol Chem 2000, 275:10661-10672.
34. Seetharam L, Gotoh N, Maru Y, Neufeld G, Yamaguchi S, Shibuya M: A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF. Oncogene 1995, 10:135-147.
35. Tanaka K, Abe M, Sato Y: Roles of extracellular signal-regulated kinase 1/2 and p38 MAPK in the signal transduction of basic fibroblast groeth factor in endothelial cells during angiogenesis. Jpn J Cancer Res 1999, 90:647-654.
36. Petrova TV, Makinen T, Alitalo K: Signaling via vascular endothelial growth factor receptors. Exp Cell Res 1999, 253:117-130.
37. Loh C, Shaw KT, Carew J, Viola JP, Luo C, Perrino BA, Rao A: Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity. J Biol Chem 1996, 271:10884-10891.
38. Shaw KT, Ho AM, Raghavan A, Kim J, Jain J, Park J, Sharma S, Rao A, Hogan PG: Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells. Proc Natl Acad Sci U S A 1995, 92:11205-11209.
39. Schreiber SL, Crabtree GR: The mechanism of action of cyclosporin A and FK506. Immunol Today 1992, 13:136-142.
40. Northrop JP, Ho SN, Chen L, Thomas DJ, Timmerman LA, Nolan GP, Admon A, Crabtree GR: NF-AT components define a family of transcription factors targeted in T-cell activation. Nature 1994, 369:497-502.
41. Garcia JE, de Cabo MR, Rodriguez FM, Losada JP, Lopez AJ, Arellano JL: Effect of cyclosporin A on inflammatory cytokine production by U937 monocyte-like cells. Mediators Inflamm 2000, 9:169-174.
42. Yoshida S, Ono M, Shono T, Izumi H, Ishibashi T, Suzuki H, Kuwano M: Involvement of Interleukin-8, Vascular Endothelial Growth Factor, and Basic Fibroblast Growth Factor in Tumor Necrosis Factor Alpha-Dependent Angiogenesis. Mol Cell Biol 1997, 17:4015-4023.
43. Tsujii M, Kawano S, Tsuji S, Sawaoka H, Hori M, DuBois RN: Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell 1998, 93:705-716.
44. Smith WL, Garavito RM, DeWitt DL: Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2. J Biol Chem 1996, 271:33157-33160.
45. Iniguez MA, Punzon C, Fresno M: Induction of cyclooxygenase-2 on activated T lymphocytes: regulation of T cell activation by cyclooxygenase-2 inhibitors. J Immunol 1999, 163:111-119.
46. Inoue H, Yokoyama C, Hara S, Tone Y, Tanabe T: Transcriptional regulation of human prostaglandin-endoperoxide synthase-2 gene by lipopolysaccharide and phorbol ester in vascular endothelial cells. Involvement of both nuclear factor for interleukin-6 expression site and cAMP response element. J Biol Chem 1995, 270:24965-24971.
47. Yu Y, Sato JD: MAP kinases, phosphatidylinositol 3-kinase, and p70 S6 kinase mediate the mitogenic response of human endothelial cells to vascular endothelial growth factor. J Cell Physiol 1999, 178:235-246.
48. Vinals F, Chambard JC, Pouyssegur J: p70 S6 kinase-mediated protein synthesis is a critical step for vascular endothelial cell proliferation. J Biol Chem 1999, 274:26776-26782.
49. Bancroft CC, Chen Z, Yeh J, Sunwoo JB, Yeh NT, Jackson S, Jackson C, Van Waes C: Effects of pharmacologic antagonists of epidermal growth factor receptor, P13K and MEK signal kinases on NF-kappaB and AP-1 activation and IL-8 and VEGF expression in human head and neck squamous cell carcinoma lines. Int J Cancer 2002, 99:538-548.
50. Minet E, Michel G, Mottet D, Piret JP, Barbjeux A, Raes M, Michiels C: c-JUN gene induction and AP-1 activity is regulated by a JNK-dependent pathway in hypoxic HepG2 cells. Exp Cell Res 2001, 265:114-124.
51. Strieter RM, Polverini PJ, Kunkel SL, Arenberg DA, Burdick MD, Kasper J, Dzuiba J, Van Damme J, Walz A, Marriott D, Chan S, Rocziak S, Shanafelt AB: The functional role of the ELR motif in CXC chemokine-mediated angiogenesis. J Biol Chem 1995, 270:27348-57.
52. Denes L, Jednakovits A, Hargitai J, Penzes Z, Balla A, Talosi L, Krajcsi P, Csermely P: Pharmacologically activated migration of aortic endothelial cells is mediated through p38 SAPK. Br J Pharma 2002, 136:597-503.
53. Salvucci O, Yao L, Villalba S, Sajewicz A, Pittaluga S, Tosato G: Regulation of endothelial cell branching morphogenesis by endogenous chemokine stromal-derived factor-1. Blood 2002, 99:2703-2711.
54. Rafiee P, Lee JK, Leung CC, Raffin TA: TNF - a induces tyrosine phosphorylation of mitogen-activated protein kinase in adherent human neutrophils. J Immunol 1995, 154:4785-4792.