Corneal neovascularization induced by xenografts or chemical cautery: Inhibition by cyclosporin A

Investigative Ophthalmology and Visual Science

Volumn 38, Issue 2, 1997, Pages 274-282

  Benelli, Umberto ^a,b   Ross, Joel R ^a   Nardi, Marco ^b   Klintworth, Gordon K ^a  

^a DUKE UNIVERSITY EYE CENTER   (United States)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

angiogenesis; corneal transplantation; cyclosporin A; immunoregulation; xenotransplantation

Indexed keywords

CYCLOSPORIN A;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLINDNESS; CAUTERIZATION; CONTROLLED STUDY; CORNEA NEOVASCULARIZATION; CORNEA TRANSPLANTATION; GRAFT SURVIVAL; IMAGE ANALYSIS; IMMUNOREGULATION; INTRAOCULAR DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; VISUAL ACUITY; XENOGRAFT; XENOTRANSPLANTATION;

ADMINISTRATION, TOPICAL; ANIMALS; CAUTERY; CORNEA; CORNEAL NEOVASCULARIZATION; CORNEAL TRANSPLANTATION; CYCLOSPORINE; DRUG COMBINATIONS; GUINEA PIGS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOSUPPRESSIVE AGENTS; INJECTIONS, SUBCUTANEOUS; MALE; NITRATES; OPHTHALMIC SOLUTIONS; POTASSIUM COMPOUNDS; RATS; RATS, INBRED LEW; SILVER NITRATE; TRANSPLANTATION, HETEROLOGOUS;

EID: 0031050060     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (59)

1. Klintworth GK. Post Inflammatory Neovascularization. In: Pepose JS, Holland GN, Wilhelmus KR, eds. Ocular Infection and Immunity. St. Louis: Mosby-Year Book; 1996:112-132.
2. Folkman J, Shing Y. Angiogenesis. J Biol Chem. 1992;267:10931-10934
3. Coster DJ, Williams KA. Transplantation of the cornea. Med J Aust. 1992;157:405-408.
4. Collin HB. Endothelial cell lined lymphatics in the vascularized rabbit cornea. Invest Ophthalmol Vis Sci. 1966;5:337-354.
5. Smolin G, Hyndiuk RA. Lymphatic drainage from vascularized rabbit cornea. Am J Ophthalmol. 1971;72:147-151.
6. Kervick GN, Shepherd WF. The pattern of corneal graft rejection. Cornea. 1990;9:234-237.
7. Duijvestijn AM, Horst E, Pals ST, et al. High endothelial differentiation in human lymphoid and inflammatory tissues defined by monoclonal antibody HECA-452. Am J Pathol. 1988;130:147-155.
8. Knowles DM, 2d, Tolidjian B, Marboe C, et al. Monoclonal anti-human monocyte antibodies OKM1 and OKM5 possess distinctive tissue distributions including differential reactivity with vascular endothelium. J Immunol. 1984;132:2170-2173.
9. Butcher EC, Lewinsohn D, Duijvestijn A, et al. Interactions between endothelial cells and leukocytes. J Cell Biochem. 1986;30:121-131.
10. Nussenblatt RB, Palestine AG. Cyclosporine: immunology, pharmacology and therapeutic uses. Surv Ophthalmol. 1986;31:159-169.
11. Belin MW, Bouchard CS, Phillips TM. Update on topical cyclosporin A. Background, immunology, and pharmacology. Cornea. 1990;9:184-195.
12. Ross JR, Howell DN, Sanfilippo FP. Characteristics of corneal xenograft rejection in a discordant species combination. Invest Ophthalmol Vis Sci. 1993;34:2469-2476.
13. Ross JR, He YG, Pidherney M, et al. The differential effects of donor versus host Langerhans cells in the rejection of MHC-matched corneal allografts. Transplantation. 1991;52:857-861.
14. 125I] radioimmunoassay. Ther Drug Monitor. 1992;14:226-233.
15. Chan GL, Weinstein SS, LeFor WW, et al. Relative performance of specific and nonspecific fluorescence polarization immunoassay for cyclosporine in transplant patients. Ther Drug Monitor. 1992;14:42-47.
16. Burger PC, Chandler DB, Klintworth GK. Corneal neovascularization as studied by scanning electron microscopy of vascular casts. Lab Invest. 1983;48:169-180.
17. Haynes WL, Proia AD, Klintworth GK. Effect of inhibitors of arachidonic acid metabolism on corneal neovascularization in the rat. Invest Ophthalmol Vis Sci. 1989;30:1588-1593.
18. Proia AD, Chandler DB, Haynes WL, et al. Quantitation of corneal neovascularization using computerized image analysis. Lab Invest. 1988;58:473-479.
19. Fajardo LF, Kowalski J, Kwan HH, et al. The disc angiogenesis system. Lab Invest. 1988;58:718-724.
20. Kowalski J, Kwan HH, Prionas SD, et al. Characterization and applications of the disc angiogenesis system. Exp Mol Pathol. 1992;56:1-19.
21. Wassef R, Cohen Z, Langer B. Pharmacokinetic profiles of cyclosporine in rats. Influence of route of administration and dosage. Transplantation. 1985;40:489-493.
22. Bhattacherjee P, Williams RN, Eakins KE. A comparison of the ocular anti-inflammatory activity of steroid and nonsteroidal compounds in the rat. Invest Ophthalmol Vis Sci. 1983;24:1143-1146.
23. Lorenzetti DWC, Kaufman HE. Experimental production of graft reactions with suppression by topical corticosteroids. Arch Ophthalmol. 1966;76:274-281.
24. Li WW, Casey R, Gonzalez EM, et al. Angiostatic steroids potentiated by sulfated cyclodextrins inhibit corneal neovascularization. Invest Ophthalmol Vis Sci. 1991;32:2898-2905.
25. Reed JW, Fromer C, Klintworth GK. Induced corneal vascularization remission with Argon laser therapy. Arch Ophthalmol. 1975;93:1017-1019.
26. 2 levels. Br J Ophthalmol. 1984;68:656-659.
27. Robin JB, Regis-Pacheco LF, Kash RL, et al. The histopathology of corneal neovascularization. Inhibitor effects. Arch Ophthalmol. 1985;103:284-287.
28. Haynes WL, Hirakata A, Proia AD. Inhibition of corneal neovascularization in the rat by SK&F 86002, a dual inhibitor of arachidonic acid metabolism. Exp Eye Res. 1992;55:189-191.
29. Williams KA, Erickson SA, Coster DJ. Topical steroid, cyclosporin A, and the outcome of rat corneal allografts. Br J Ophthalmol. 1987;71:239-242.
30. Herbort CP, Matsubara M, Nishi M, et al. Penetrating keratoplasty in the rat: a model for the study of immunosuppressive treatment of graft rejection. Jpn J Ophthalmol. 1989;33:212-220.
31. Bouchard CS, Kappil JC, Duffner L. The role of systemic cyclosporine dosing schedule on corneal allo graft survival in the rat model. Curr Eye Res. 1995;14:421-424.
32. Coupland SE, Klebe S, Karow AC, et al. Leflunomide therapy following penetrating keratoplasty in the rat. Graefes Arch Clin Exp Ophthalmol. 1994;232:622-627.
33. Niederkorn JY, Lang LS, Ross J, et al. Promotion of corneal allograft survival with leflunomide. Invest Ophthalmol Vis Sci. 1994;35:3783-3785.
34. Milani JK, Pleyer U, Dukes A, et al. Prolongation of corneal allograft survival with liposome-encapsulated cyclosporine in the rat eye. Ophthalmology. 1993;100:890-896.
35. Levinger S, Zauberman H. Effects of systemic administration of Chlorambucil and topical application of Cyclosporin A on corneal graft survival in rabbits. Israel J Med Sci. 1985;21:670-674.
36. Foets B, Missotten L, Vanderveeren P, et al. Prolonged survival of allogeneic corneal grafts in rabbits treated with topically applied cyclosporin A: systemic absorption and local immunosuppressive effect. Br J Ophthalmol. 1985;69:600-603.
37. Newton C, Gebhardt BM, Kaufman HE. Topically applied cyclosporine in azone prolongs corneal allograft survival. Invest Ophthalmol Vis Sci. 1988;29:208-215.
38. Williams KA, Grutzmacher RD, Roussel TJ, et al. A comparison of the effects of topical cyclosporine and topical steroid on rabbit corneal allograft rejection. Transplantation. 1985;39:242-244.
39. Hunter PA, Garner A, Wilhelmus KR, et al. Corneal graft rejection: a new rabbit model and cyclosporin-A. Br J Ophthalmol. 1982;66:292-302.
40. Kaswan RL, Salisbury MA, Ward DA. Spontaneous canine keratoconjunctivitis sicca. A useful model for human keratoconjunctivitis sicca: treatment with cyclosporine eye drops. Arch Ophthalmol. 1989;107:1210-1216.
41. Lipman RM, Epstein RJ, Hendricks RL. Suppression of corneal neovascularization with cyclosporine. Arch Ophthalmol. 1992;110:405-407.
42. Norrby K. Cyclosporine is angiostatic. Experientia. 1992;48:1135-1138.
43. Won YH, Sauder DN, McKenzie RC. Cyclosporin A inhibits keratinocyte cytokine gene expression. Br J Dermatol. 1994;130:312-319.
44. Chabannes D, Le Mauff B, Hallet MM, et al. Effect of cyclosporine on interleukin 2 receptor expression in a human alloreactive T cell clone. Transplantation. 1988;46:97S-100S.
45. Kaufmann Y, Chang AE, Robb RJ, et al. Mechanism of action of Cyclosporin A: inhibition of lymphokine secretion studied with antigen-stimulated T cell hybridomas. J Immunol. 1984;133:3107-3111.
46. Epstein RJ, Stulting RD, Hendricks RL, et al. Corneal neovascularization. Pathogenesis and inhibition. Cornea. 1987;6:250-257.
47. Kurokawa T, Nonami T, Kobayashi H, et al. Inhibition by cyclosporine of the production of superoxide radicals. N Engl J Med. 1992;326:840.
48. Wenzel-Seifert K, Schachtele C, Hummel R, et al. Evidence that inhibition of phorbol ester-induced superoxide anion formation by cyclosporin A in phagocytes is not mediated by direct inhibition of protein kinase C. Biochem Pharmacol. 1994;48:859-864.
49. Sharpe RJ, Arndt KA, Bauer SI, et al. Cyclosporine inhibits basic fibroblast growth factor-driven proliferation of human endothelial cells and keratinocytes. Arch Dermatol. 1989;125:1359-1362.
50. Scroggs MW, Proia AD, Smith CF, et al. The effect of total-body irradiation on corneal neovascularization in the Fischer 344 rat after chemical cauterization. Invest Ophthalmol Vis Sci. 1991;32:2105-2111.
51. Brogi E, Wu T, Namiki A, et al. Indirect angiogenic cytokines upregulate VEGF and bFGF gene expression in vascular smooth muscle cells, whereas hypoxia upregulates VEGF expression only. Circulation. 1994;90:649-652.
52. Wakefield D, Lloyd A. The role of cytokines in the pathogenesis of inflammatory eye disease. Cytokine. 1992;4:1-5.
53. Watt SL, Auerbach R. A mitogenic factor for endothelial cells obtained from mouse secondary mixed leukocyte cultures. J Immunol. 1986;136:197-202.
54. Roberts AB, Sporn MB, Assoian RK, et al. Trans forming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci U S A. 1986;83:4167-4171.
55. Suvarnamani C, Halperin EC, Proia AD, et al. The effects of total lymphoid irradiation upon corneal vascularization in the rat following chemical cautery. Radiat Res. 1989;117:259-272.
56. Lau DC, Wong KL, Hwang WS. Cyclosporine toxicity on cultured rat microvascular endothelial cells. Kidney Int. 1989;35:604-613.
57. Gallego MJ, Garcia Villalon AL, Lopez Farre AJ, et al. Mechanisms of the endothelial toxicity of cyclosporin A. Role of nitric oxide, cGMP, and Ca2+. Circ Res. 1994;74:477-484.
58. Berkenboom G, Unger P, Goldman M, et al. Prevention of cyclosporine A-induced vascular toxicity by pentoxifylline. J Cardiovasc Pharmacol. 1991;18:761-768.
59. Koch AE, Halloran MM, Haskell CJ, et al. Angiogenesis mediated by soluble forms of E-selectin and vascular cell adhesion molecule-1. Nature. 1995;376:517-519.