Mechanisms related to neuron injury and death in cerebral hypoxic ischaemia

Folia Neuropathologica

Volumn 49, Issue 2, 2011, Pages 78-87

  Guo, Min Fang ^a   Yu, Jie Zhong ^a   Ma, Cun Gen ^a  

^a SHANXI DATONG UNIVERSITY   (China)

Author keywords

Calcium; Cell apoptosis; Chondriosome; Complement component; Dopamine; Excitatory amino acid; Free radical; Hypoxic ischaemia; Immunological inflammation; Matrix metalloproteinase; Neuron; NO

Indexed keywords

ASPARTIC ACID; CALCIUM; CASPASE 3; CHEMOTACTIC FACTOR; COMPLEMENT COMPONENT C3A; COMPLEMENT COMPONENT C5A; DOPAMINE; EXCITATORY AMINO ACID; FAS LIGAND; FREE RADICAL; GELATINASE A; GELATINASE B; GLUTAMIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1; INTERLEUKIN 2; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; NEURONAL NITRIC OXIDE SYNTHASE; NEUROTROPHIN 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NITRIC OXIDE; NORPHENAZONE; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR; UNINDEXED DRUG; XRCC1 PROTEIN;

ASTROCYTE; BLOOD BRAIN BARRIER; CALCIUM CELL LEVEL; COMPLEMENT ACTIVATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; HUMAN; HYPOXIC ISCHEMIC ENCEPHALOPATHY; IMMUNE SYSTEM; INFLAMMATION; INTRACELLULAR SIGNALING; NERVE CELL LESION; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PATHOGENESIS; PROTEIN HYDROLYSIS; REVIEW;

EID: 79960472962     PISSN: 16414640     EISSN: 1509572X     Source Type: Journal    
DOI: None     Document Type: Review

References (63)

1. Anthony L, David J, Sander E. The role of the complement cascade in ischemic/ reperfusion injury: implications for neuroprotection. Mol Med 2001; 7: 367-382.
2. Arranz AM, Gottlieb M, Pérez-Cerdá F, Matute C. Increased expression of glutamate transporters in subcortical white matter after transient focal cerebral ischemia. Neurobiol Dis 2010; 37: 156-165.
3. Bates B, Hirt L, Thomas SS, Akbarian S, Le D, Amin-Hanjani S, Whalen M, Jaenisch R, Moskowitz MA. Neurotrophin-3 promotes cell death induced in cerebral ischemia, oxygen-glucose deprivation, and oxidative stress: possible involvement of oxygen free radicals. Neurobiol Dis 2002; 9: 24-37. (Pubitemid 34174562)
4. Bolaños JP, Herrero-Mendez A, Fernandez-Fernandez S, Almeida A. Linking glycolysis with oxidative stress in neural cells: a regulatory role for nitric oxide. Biochem Soc Trans 2007; 35 (Pt 5): 1224-1227. (Pubitemid 350206467)
5. Brown GC. Nitric oxide and neuronal death. Nitric Oxide 2010; 23: 153-165.
6. Büyükuysal RL, Mete B. Anoxia-induced dopamine release from rat striatal slices: involvement of reverse transport mechanism. J Neurochem 1999; 72: 1507-1515. (Pubitemid 29140822)
7. Chen H, Kim GS, Okami N, Narasimhan P, Chan PH. NADPH oxidase is involved in post-ischemic brain inflammation. Neurobiol Dis 2011; 42: 341-348.
8. Cheung HH, Teves L, Wallace MC, Gurd JW. Increased phosphorylation of the NR1 subunit of the NMDA receptor following cerebral ischemia. J Neurochem 2001; 78: 1179-1182. (Pubitemid 32823167)
9. Chi OZ, Hunter C, Liu X, Weiss HR. Effects of exogenous excitatory amino acid neurotransmitters on blood-brain barrier disruption in focal cerebral ischemia. Neurochem Res 2009; 34: 1249-1254.
10. Cowell RM, Plane JM, Silverstein FS. Complement activation contributes to hypoxic-ischemic brain injury in neonatal rats. J Neurosci 2003; 23: 9459-9468. (Pubitemid 37323048)
11. Del Zoppo G, Ginis I, Hallenbeck JM, Iadecola C, Wang X, Feuerstein GZ. Inflammation and stroke: putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia. Brain Pathol 2000; 10: 95-112. (Pubitemid 30056398)
12. Dijkhuizen RM, Asahi M, Wu O, Rosen BR, Lo EH. Rapid breakdown of microvascular barriers and subsequent hemorrhagic transformation after delayed recombinant tissue plasminogen activator treatment in a rat embolic stroke model. Stroke 2002; 33: 2100-2104. (Pubitemid 34840075)
13. Dirnagl U, Iadecola C, Moskowitz MA. Pathobiology of is chaemic stroke: an integrated view. Trends Neurosci 1999; 22: 391-397. (Pubitemid 29453643)
14. Ezquer ME, Valdez SR, Seltzer AM. Inflammatory responses of the substantia nigra after acute hypoxia in neonatal rats. Exp Neurol 2006; 197: 391-398. (Pubitemid 43077147)
15. Fujimoto M, Takagi Y, Aoki T, Hayase M, Marumo T, Gomi M, Nishimura M, Kataoka H, Hashimoto N, Nozaki K. Tissue inhibitor of metalloproteinases protect blood-brain barrier disruption in focal cerebral ischemia. J Cereb Blood Flow Metab 2008; 28: 1674-1685.
16. Ginet V, Puyal J, Clarke PG, Truttmann AC. Enhancement of autophagic flux after neonatal cerebral hypoxia-ischemia and its region-specific relationship to apoptotic mechanisms. Am J Pathol 2009; 175: 1962-1974.
17. Green DR, Reed JC. Mitochondria and apoptosis. Science 1998; 281: 1309-1312. (Pubitemid 28406816)
18. Gurd JW, Bissoon N, Beesley PW, Nakazawa T, Yamamoto T, Vannucci SJ. Differential effects of hypoxia-ischemia on subunit expression and tyrosine phosphorylation of the NMDA receptor in 7- and 21-day-old rats. J Neurochem 2002; 82: 848-856.
19. Haddad GG, Jiang C. O2 deprivation in the central nervous system, on mechanisms of neuronal response, differential sensitivity and injury. Prog Neurobiol 1993; 40: 277-318. (Pubitemid 23017424)
20. Han F, Shioda N, Moriguchi S, Qin ZH, Fukunaga K. Downregulation of glutamate transporters is associated with elevation in extracellular glutamate concentration following rat microsphere embolism. Neurosci Lett 2008; 430: 275-280.
21. Hilton GD, Nunez JL, Bambrick L, Thompson SM, McCarthy MM. Glutamate-mediated excitotoxicity in neonatal hippocampal neurons is mediated by mGluR-induced release of Ca++ from intracellular stores and is prevented by estradiol. Eur J Neurosci 2006; 24: 3008-3016. (Pubitemid 44952633)
22. Huang L, Chen N, Ge M, Zhu Y, Guan S, Wang JH. Ca2+ and acidosis synergistically lead to the dysfunction of cortical GABAergic neurons during ischemia. Biochem Biophys Res Commun 2010; 394: 709-714.
23. Katayama Y, Tamura T, Becker DP, Tsubokawa T. Early cellular swelling during cerebral ischemia in vivo is mediated by excitatory amino acids released from nerve terminals. Brain Res 1992; 577: 121-126.
24. Kikuchi K, Kawahara K, Tancharoen S, Matsuda F, Morimoto Y, Ito T, Biswas KK, Takenouchi K, Miura N, Oyama Y, Nawa Y, Arimura N, Iwata M, Tajima Y, Kuramoto T, Nakayama K, Shigemori M, Yoshida Y, Hashiguchi T, Maruyama I. The free radical scavenger edaravone rescues rats from cerebral infarction by attenuating the release of high-mobility group box-1 in neuronal cells. J Pharmacol Exp Ther 2009; 329: 865-874.
25. Kimelberg HK, Nestor NB, Feustel PJ. Inhibition of release of taurine and excitatory amino acids in ischemia and neuroprotection. Neurochem Res 2004; 29: 267-274. (Pubitemid 38181720)
26. Kokubo Y, Matson GB, Liu J, Mancuso A, Kayama T, Sharp FR, Weinstein PR. Correlation between changes in apparent diffusion coefficient and induction of heat shock protein, cell-specific injury marker expression, and protein synthesis reduction on diffusion-weighted magnetic resonance images after temporary focal cerebral ischemia in rats. J Neurosurg 2002; 96: 1084-1093. (Pubitemid 34579027)
27. Kumar A, Mittal R, Khanna HD, Basu S. Free radical injury and blood-brain barrier permeability in hypoxic-ischemic encephalopathy. Pediatrics 2008; 122: e722-727.
28. Li Q, Zhang R, Ge YL, Mei YW, Guo YL. Effects of neuregulin on expression of MMP-9 and NSE in brain of ischemia/reperfusion rat. J Mol Neurosci 2009; 38: 207-215.
29. Li S, Wang W, Wang C, Tang YY. Possible involvement of NO/NOS signaling in hippocampal amyloid-beta production induced by transient focal cerebral ischemia in aged rats. Neurosci Lett 2010; 470: 106-110.
30. Li XM, Yang JM, Hu DH, Hou FQ, Zhao M, Zhu XH, Wang Y, Li JG, Hu P, Chen L, Qin LN, Gao TM. Contribution of downregulation of L-type calcium currents to delayed neuronal death in rat hippocampus after global cerebral ischemia and reperfusion. J Neurosci 2007; 27: 5249-5259. (Pubitemid 46741793)
31. Liu N, DU HW, Chen RH, Zheng A, Huang HP, Wu ZH. The effect of interleukin-10 on neurocyte apoptosis in cerebral ischemia in rats. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2007; 23: 498-500.
32. Loh KP, Huang SH, De Silva R, Tan BK, Zhu YZ. Oxidative stress: apoptosis in neuronal injury. Curr Alzheimer Res 2006; 3: 327-337. (Pubitemid 44351476)
33. Maiti P, Singh SB, Ilavazhagan G. Nitric oxide system is involved in hypobaric hypoxia-induced oxidative stress in rat brain. Acta Histochem 2010; 112: 222-232.
34. Montaner J, Molina CA, Monasterio J, Abilleira S, Arenillas JF, Ribó M, Quintana M, Alvarez-Sabín J. Matrix metalloproteinase-9 pretreatment level predicts intracranial hemorrhagic complications after thrombolysis in human stroke. Circulation 2003; 107: 598-603. (Pubitemid 36176811)
35. Moyanova SG, Mastroiacovo F, Kortenska LV, Mitreva RG, Fardone E, Santolini I, Sobrado M, Battaglia G, Bruno V, Nicoletti F, Ngomba RT. Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. J Cereb Blood Flow Metab 2011; 31: 1107-1118.
36. Murotomi K, Takagi N, Mizutani R, Honda TA, Ono M, Takeo S, Tanonaka K. mGluR1 antagonist decreased NADPH oxidase activity and superoxide production after transient focal cerebral ischemia. J Neurochem 2010; 114: 1711-1719.
37. Murotomi K, Takagi N, Takayanagi G, Ono M, Takeo S, Tanonaka K. mGluR1 antagonist decreases tyrosine phosphorylation of NMDA receptor and attenuates infarct size after transient focal cerebral ischemia. J Neurochem 2008; 105: 1625-1634. (Pubitemid 351678489)
38. Niizuma K, Yoshioka H, Chen H, Kim GS, Jung JE, Katsu M, Okami N, Chan PH. Mitochondrial and apoptotic neuronal death signaling pathways in cerebral ischemia. Biochim Biophys Acta 2010; 1802: 92-99.
39. Phillis JW, O'Regan MH. Characterization of modes of release of amino acids in the ischemic/reperfused rat cerebral cortex. Neurochem Int 2003; 43: 461-467. (Pubitemid 36561300)
40. Qin AP, Zhang HL, Qin ZH. Mechanisms of lysosomal proteases participating in cerebral ischemia-induced neuronal death. Neurosci Bull 2008; 24: 117-123.
41. Racay P, Tatarkova Z, Chomova M, Hatok J, Kaplan P, Dobro - ta D. Mitochondrial calcium transport and mitochondrial dysfunction after global brain ischemia in rat hippocampus. Neurochem Res 2009; 34: 1469-1478.
42. Ridder DA, Schwaninger M. NF-kappaB signaling in cerebral ischemia. Neuroscience 2009; 158: 995-1006.
43. Riedemann NC, Ward PA. Complement in ischemia reperfusion injury. Am J Pathol 2003; 162: 363-367. (Pubitemid 36267843)
44. Rodrigo J, Fernández AP, Serrano J, Peinado MA, Martínez A. The role of free radicals in cerebral hypoxia and ischemia. Free Radic Biol Med 2005; 39: 26-50. (Pubitemid 40740221)
45. Sandoval KE, Witt KA. Blood-brain barrier tight junction permeability and ischemic stroke. Neurobiol Dis 2008; 32: 200-219.
46. Srivastava AK, Kalita J, Dohare P, Ray M, Misra UK. Studies of free radical generation by neurons in a rat model of cerebral venous sinus thrombosis. Neurosci Lett 2009; 450: 127-131.
47. Szaflarski J, Burtrum D, Silverstein FS. Cerebral hypoxiaischemia stimulates cytokine gene expression in perinatal rats. Stroke 1995; 26: 1093-1100.
48. Szydlowska K, Tymianski M. Calcium, ischemia and excito-toxicity. Cell Calcium 2010; 47: 122-129.
49. Takagi N, Besshoh S, Morita H, Terao M, Takeo S, Tanonaka K. Metabotropic glutamate mGlu5 receptor-mediated serine phosphorylation of NMDA receptor subunit NR1 in hippocampal CA1 region after transient global ischemia in rats. Eur J Pharmacol 2010; 644: 96-100.
50. Takeuchi H, Jin S, Suzuki H, Doi Y, Liang J, Kawanokuchi J, Mizuno T, Sawada M, Suzumura A. Blockade of microglial glutamate release protects against ischemic brain injury. Exp Neurol 2008; 214: 144-146.
51. Ten VS, Yao J, Ratner V, Sosunov S, Fraser DA, Botto M, Sivasankar B, Morgan BP, Silverstein S, Stark R, Polin R, Vannucci SJ, Pinsky D, Starkov AA. Complement component c1q mediates mitochondria-driven oxidative stress in neonatal hypoxic-ischemic brain injury. J Neurosci 2010; 30: 2077-2087.
52. Van der Vliet A, Smith D, O'Neill CA, Kaur H, Darley-Usmar V, Cross CE, Halliwell B. Interactions of peroxynitrite with human plasma and its constituents: oxidative damage and antioxidant depletion. Biochem J 1994; 303: 295-301. (Pubitemid 24302933)
53. Verma R, Mishra V, Sasmal D, Raghubir R. Pharmacological evaluation of glutamate transporter 1 (GLT-1) mediated neuroprotection following cerebral ischemia/reperfusion injury. Eur J Pharmacol 2010; 638: 65-71.
54. Wang CX, Shuaib A. Involve of inflammatory cytokines in central nervous system injury. Prog Neurobiol 2002; 67: 161-172. (Pubitemid 34786168)
55. Wang WW, Hu SQ, Li C, Zhou C, Qi SH, Zhang GY. Transduced PDZ1 domain of PSD-95 decreases Src phosphorylation and increases nNOS (Ser847) phosphorylation contributing to neuroprotection after cerebral ischemia. Brain Res 2010; 1328: 162-170.
56. Xu MS, Fang C, Xu J, Zhang GF, Ge LB. Dynamic changes of dopamine and its metabolite levels in the rat striatum after cerebral ischemia-reperfusion and electroacupuncture. Zhen Ci Yan Jiu 2009; 34: 230-235.
57. Xu XH, Zheng XX, Zhou Q, Li H. Inhibition of excitatory amino acid efflux contributes to protective effects of puerarin against cerebral ischemia in rats. Biomed Environ Sci 2007; 20: 336-342. (Pubitemid 47441814)
58. Yang Y, Candelario-Jalil E, Thompson JF, Cuadrado E, Estrada EY, Rosell A, Montaner J, Rosenberg GA. Increased intranuclear matrix metalloproteinase activity in neurons interferes with oxidative DNA repair in focal cerebral ischemia. J Neurochem 2010; 112: 134-149.
59. Yin W, Signore AP, Iwai M, Cao G, Gao Y, Chen J. Rapidly increased neuronal mitochondrial biogenesis after hypoxicischemic brain injury. Stroke 2008; 39: 3057-3063.
60. Yoshimoto K, Hori M, Shinmen N, Kakiuchi K, Kato H, Sakabe M, Ikegaya H. Forensic studies of brain vulnerability and resistance: ischemia-induced dopamine and serotonin releases in the rat nucleus accumbens. Leg Med (Tokyo) 2009; 11 (Suppl 1): S279-281.
61. Yu Z, Li S, Lv SH, Piao H, Zhang YH, Zhang YM, Ma H, Zhang J, Sun CK, Li AP. Hypoxia-ischemia brain damage disrupts brain cholesterol homeostasis in neonatal rats. Neuropediatrics 2009; 40: 179-185.
62. Zhou L, Li F, Xu HB, Luo CX, Wu HY, Zhu MM, Lu W, Ji X, Zhou QG, Zhu DY. Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95. Nat Med 2010; 16: 1439-1443.
63. Zhu C, Hallin U, Ozaki Y, Grandér R, Gatzinsky K, Bahr BA, Karlsson JO, Shibasaki F, Hagberg H, Blomgren K. Nuclear translocation and calpain-dependent reduction of Bcl-2 after neonatal cerebral hypoxia-ischemia. Brain Behav Immun 2010; 24: 822-830.