Increased expression of glutamate transporters in subcortical white matter after transient focal cerebral ischemia

Neurobiology of Disease

Volumn 37, Issue 1, 2010, Pages 156-165

  Arranz, Amaia M ^a   Gottlieb, Miroslav ^a,b   Pérez Cerdá, Fernando ^a   Matute, Carlos ^a  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^b INSTITUTE OF CHEMISTRY   (Slovakia)

Author keywords

Excitotoxicity; Glutamate transporters; Ischemia; Subcortical white matter

Indexed keywords

EXCITATORY AMINO ACID TRANSPORTER 1; EXCITATORY AMINO ACID TRANSPORTER 2; EXCITATORY AMINO ACID TRANSPORTER 3; GLUTAMATE TRANSPORTER;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN DAMAGE; BRAIN INFARCTION; BRAIN ISCHEMIA; CONTROLLED STUDY; EXCITOTOXICITY; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MALE; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION; WESTERN BLOTTING; WHITE MATTER;

ANIMALS; ASTROCYTES; BLOTTING, WESTERN; BRAIN; BRAIN ISCHEMIA; EXCITATORY AMINO ACID TRANSPORTER 1; EXCITATORY AMINO ACID TRANSPORTER 2; EXCITATORY AMINO ACID TRANSPORTER 3; IMMUNOHISTOCHEMISTRY; INFARCTION, MIDDLE CEREBRAL ARTERY; MACROPHAGES; MALE; MICROGLIA; NERVE FIBERS, MYELINATED; NEUROLOGIC EXAMINATION; RATS; RATS, WISTAR; TIME FACTORS;

EID: 70449535512     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2009.09.019     Document Type: Article

References (43)

1. Anderson C.M., and Swanson R.A. Astrocyte glutamate transport: review of properties, regulation, and physiological functions. Glia 32 (2000) 1-14
2. Arranz A.M., Hussein A., Alix J.J., Pérez-Cerdá F., Allcock N., Matute C., and Fern R. Functional glutamate transport in rodent optic nerve axons and glia. Glia 56 (2008) 1353-1367
3. Bederson J.B., Pitts L.H., Tsuji M., Nishimura M.C., Davis R.L., and Bartkowski H. Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 17 (1986) 472-476
4. Beschorner R., Dietz K., Schauer N., Mittelbronn M., Schluesener H.J., Trautmann K., Meyermann R., and Simon P. Expression of EAAT1 reflects a possible neuroprotective function of peri-infarct astrocytes and activated microglia following human traumatic brain injury. Histol. Histopathol. 22 (2007) 515-526
5. Beschorner R., Simon P., Schauer N., Mittelbronn M., Schluesener H.J., Trautmann K., Dietz K., and Meyermann R. Peri-infarct astrocytes and activated microglial cells express EAAT1, but not EAAT2, reflecting a neuroprotective potential following ischaemia. Histopathology 50 (2007) 897-910
6. Bhat R.V., Axt K.J., Fosnaugh J.S., Smith K.J., Johnson K.A., Hill D.E., Kinzler K.W., and Baraban J.M. Expression of the APC tumor supressor protein in oligodendroglia. Glia 17 (1996) 169-174
7. Chen J.C., Hsu-Chou H., Lu J.L., Chiang Y.C., Huang H.M., Wang H.L., Wu T., Liao J.J., and Yeh T.S. Down-regulation of the glial glutamate transporter GLT-1 in rat hippocampus and striatum and its modulation by a group III metabotropic glutamate receptor antagonist following transient global forebrain ischemia. Neuropharmacology 49 (2005) 703-714
8. Choi D.W. Glutamate neurotoxicity and diseases of the nervous system. Neuron 1 (1988) 623-634
9. Conti F., DeBiasi S., Minelli A., Rothstein J.D., and Melone M. EAAC1, a high-affinity glutamate transporter, is localized to astrocytes and GABAergic neurons besides pyramidal cells in the rat cerebral cortex. Cereb. Cortex 8 (1998) 108-116
10. Danbolt N.C. Glutamate uptake. Prog. Neurobiol. 65 (2001) 1-105
11. Dawson L.A., Djali S., Gonzales C., Vinegra M.A., and Zaleska M.M. Characterization of transient focal ischemia-induced increases in extracellular glutamate and aspartate in spontaneously hypertensive rats. Brain Res. Bull. 53 (2000) 767-776
12. Domercq M., and Matute C. Expression of glutamate transporters in the adult bovine corpus callosum. Molecular Brain Res. 67 (1999) 296-302
13. Domercq M., Sánchez-Gómez M.V., Areso P., and Matute C. Expression of glutamate transporters in rat optic nerve oligodendrocytes. Eur. J. Neurosci. 11 (1999) 2226-2236
14. +-dependent glutamate transporter GLT1 by a neuroimmunophilin ligand results in neuroprotection. Neurobiol. Dis. 21 (2006) 56-567
15. Gottlieb M., Domercq M., and Matute C. Altered expression of the glutamate transporter EAAC1 in neurons and immature oligodendrocytes after transient forebrain ischemia. J. Cereb. Blood Flow Metab. 20 (2000) 678-687
16. Kugler P., and Beyer A. Expression of glutamate transporters in human and rat retina and rat optic nerve. Histochem. Cell Biol. 120 (2003) 199-212
17. Labrande C., Velly L., Canolle B., Guillet B., Masmejean F., Nieoullon A., and Pisano P. Neuroprotective effects of tacrolimus (FK506) in a model of ischemic cortical cell cultures: role of glutamate uptake and FK506 binding protein 12 kDa. Neuroscience 137 (2006) 231-239
18. Longa E.Z., Weinstein P.R., Carlson S., and Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20 (1989) 84-91
19. Matute C., Alberdi E., Domercq M., Pérez-Cerdá F., Pérez-Samartín A., and Sánchez-Gómez M.V. The link between excitotoxic oligodendroglial death and demyelinating diseases. Trends Neurosci. 24 (2001) 224-230
20. Matute C., Torre I., Pérez-Cerdá F., Pérez-Samartín A., Alberdi E., Etxebarria E., Arranz A.M., Ravid R., Rodríguez-Antigüedad A., Sánchez-Gómez M., and Domercq M. P2X(7) receptor blockade prevents ATP excitotoxicity in oligodendrocytes and ameliorates experimental autoimmune encephalomyelitis. J. Neurosci. 27 (2007) 9525-9533
21. + dependent glutamate transporters (EAAT1, EAAT2, and EAAT3) in primary astrocyte cultures: effect of oxidative stress. Brain Res. 922 (2001) 21-29
22. Mitani A., and Tanaka K. Functional changes of glial glutamate transporter GLT-1 during ischemia: an in vivo study in the hippocampal CA1 of normal mice and mutant mice lacking GLT-1. J. Neurosci. 23 (2003) 7176-7182
23. Namura S., Maeno H., Takami S., Jiang X.F., Kamichi S., Wada K., and Nagata I. Inhibition of glial glutamate transporter GLT-1 augments brain edema after transient focal cerebral ischemia in mice. Neurosci. Lett. 324 (2002) 117-120
24. Nakajima K., Tohyama Y., Kohsaka S., and Kurihara T. Ability of rat microglia to uptake extracellular glutamate. Neurosci. Lett. 307 (2001) 171-174
25. Peghini P., Janzen J., and Stoffel W. Glutamate transporter EAAC-1 deficient mice develop dicarboxylic aminoaciduria and behavioral abnormalities but no neurodegeneration. EMBO J. 16 (1997) 3822-3832
26. Paxinos G., and Watson C. The Rat Brain in Stereotaxic Coordinates (1998), Academic Press Inc., San Diego, CA
27. Rao V.L., Bowen K.K., and Dempsey R.J. Transient focal cerebral ischemia down-regulates glutamate transporters GLT-1 and EAAC1 expression in rat brain. Neurochem. Res. 26 (2001) 497-502
28. Rao V.L., Dogan A., Todd K.G., Bowen K.K., Kim B.T., Rothstein J.D., and Dempsey R.J. Antisense knockdown of the glial glutamate transporter GLT-1, but not the neuronal glutamate transporter EAAC1, exacerbates transient focal cerebral ischemia-induced neuronal damage in rat brain. J. Neurosci. 21 (2001) 1876-1883
29. +-dependent high-affinity glutamate transport in macrophages. J. Immunol. 164 (2000) 5430-5438
30. Rothstein J.D., Martin L., Levey A.I., Dykes-Hoberg M., Jin L., Wu D., Nash N., and Kuncl R.W. Localization of neuronal and glial glutamate transporters. Neuron 13 (1994) 713-725
31. Rothstein J.D., Dykes-Hoberg M., Pardo C.A., Bristol L.A., Jin L., Kuncl R.W., Kanai Y., Hediger M.A., Wang Y., Schielke J.P., and Welty D.F. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron 16 (1996) 675-686
32. Rothstein J.D., Patel S., Regan M.R., Haenggeli C., Huang Y.H., Bergles D.E., Jin L., Dykes-Hoberg M., Vidensky S., Chung D.S., Toan S.V., Bruijn L.I., Su Z.Z., Gupta P., and Fisher P.B. beta-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Nature 433 (2005) 73-77
33. +-dependent glutamate transporters by cyclic AMP analogs and neurons. Mol. Pharmacol. 53 (1998) 355-369
34. Schmued L.C., and Hopkins K.J. Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration. Brain Res. 874 (2000) 123-130
35. Stys P.K. White matter injury mechanisms. Curr. Mol. Med. 4 (2004) 113-130
36. Tanaka K., Watase K., Manabe T., Yamada K., Watanabe M., Takahashi K., Iwama H., Nishikawa T., Ichihara N., Kikuchi T., Okuyama S., Kawashima N., Hori S., and Tokimoto M. Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science 276 (1997) 1699-1702
37. Tekkök S.B., Ye Z., and Ransom B.R. Excitotoxic mechanisms of ischemic injury in myelinated white matter. J. Cereb. Blood Flow Metab. 27 (2007) 1540-1552
38. Vallejo-Illarramendi A., Domercq M., Pérez-Cerdá F., Ravid R., and Matute C. Increased expression and function of glutamate transporters in multiple sclerosis. Neurobiol. Dis. 21 (2006) 154-164
39. Vera-Portocarrero L.P., Mills C.D., Ye Z., Fullwood S.D., McAdoo D.J., Hulsebosch C.E., and Westlund K.N. Rapid changes in expression of glutamate transporters after spinal cord injury. Brain Res. 927 (2002) 104-110
40. Verkhratsky A., and Kirchhoff F. Glutamate-mediated neuronal-glial transmission. J. Anat. 210 (2007) 651-660
41. Watase K., Hashimoto K., Kano M., Yamada K., Watanabe M., Inoue Y., Okuyama S., Sakagawa T., Ogawa S., Kawashima N., Hori S., Takimoto M., Wada K., and Tanaka K. Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice. Eur. J. Neurosci. 10 (1998) 76-988
42. Weller M.L., Stone I.M., Goss A., Rau T., Rova C., and Poulsen D.J. Selective overexpression of excitatory amino acid transporter 2 (EAAT2) in astrocytes enhances neuroprotection from moderate but not severe hypoxia-ischemia. Neuroscience 155 (2008) 1204-1211
43. Yeh T.H., Hwang H.M., Chen J.J., Wu T., Li A.H., and Wang H.L. Glutamate transporter function of rat hippocampal astrocytes impaired following the global ischemia. Neurobiol. Dis. 18 (2005) 476-483