Metabotropic glutamate mGlu5 receptor-mediated serine phosphorylation of NMDA receptor subunit NR1 in hippocampal CA1 region after transient global ischemia in rats

European Journal of Pharmacology

Volumn 644, Issue 1-3, 2010, Pages 96-100

  Takagi, Norio ^a   Besshoh, Shintaro ^a   Morita, Hirotsugu ^a   Terao, Mihoko ^a   Takeo, Satoshi ^a   Tanonaka, Kouichi ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

Metabotropic glutamate receptor; NMDA receptor; Phosphorylation; Transient global ischemia

Indexed keywords

DEOXYCHOLIC ACID; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR ANTAGONIST; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; PROTEIN KINASE C ALPHA; PROTEIN KINASE C GAMMA; SERINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CELL DEATH; CONTROLLED STUDY; HIPPOCAMPUS; INTRACELLULAR SIGNALING; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; REPERFUSION;

ANIMALS; CA1 REGION, HIPPOCAMPAL; CELL DEATH; ISCHEMIC ATTACK, TRANSIENT; MALE; PHOSPHORYLATION; PROTEIN KINASE C; PYRIDINES; RATS; RATS, WISTAR; RECEPTORS, METABOTROPIC GLUTAMATE; RECEPTORS, N-METHYL-D-ASPARTATE; SERINE; SIGNAL TRANSDUCTION;

EID: 77955775353     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.07.026     Document Type: Article

References (30)

1. Attucci S., Carla V., Mannaioni G., Moroni F. Activation of type 5 metabotropic glutamate receptors enhances NMDA responses in mice cortical wedges. Br. J. Pharmacol. 2001, 132:799-806.
2. Awad H., Hubert G.W., Smith Y., Levey A.I., Conn P.J. Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus. J. Neurosci. 2000, 20:7871-7879.
3. Bao W.L., Williams A.J., Faden A.I., Tortella F.C. Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischemia. Brain Res. 2001, 922:173-179.
4. Benquet P., Gee C.E., Gerber U. Two distinct signaling pathways upregulate NMDA receptor responses via two distinct metabotropic glutamate receptor subtypes. J. Neurosci. 2002, 22:9679-9686.
5. Blahos J., Wenthold R.J. Relationship between N-methyl-d-aspartate receptor NR1 splice variants and NR2 subunits. J. Biol. Chem. 1996, 271:15669-15674.
6. Bruno V., Ksiazek I., Battaglia G., Lukic S., Leonhardt T., Sauer D., Gasparini F., Kuhn R., Nicoletti F., Flor P.J. Selective blockade of metabotropic glutamate receptor subtype 5 is neuroprotective. Neuropharmacol 2000, 39:2223-2230.
7. 2+ block of NMDA-receptor channels as a mechanism of modulation. Nature 1992, 356:521-523.
8. Cheung H.H., Teves L., Wallace M.C., Gurd J.W. Increased phosphorylation of the NR1 subunit of the NMDA receptor following cerebral ischemia. J. Neurochem. 2001, 78:1179-1182.
9. Cheung H.H., Teves L., Wallace M.C., Gurd J.W. Inhibition of protein kinase C reduces ischemia-induced tyrosine phosphorylation of the N-methyl-d-aspartate receptor. J. Neurochem. 2003, 86:1441-1449.
10. Choe E.S., Shin E.H., Wang J.Q. Regulation of phosphorylation of NMDA receptor NR1 subunits in the rat neostriatum by group I metabotropic glutamate receptors in vivo. Neurosci. Lett. 2006, 394:246-251.
11. Doherty A.J., Palmer M.J., Henley J.M., Collingridge G.L., Jane D.E. (RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but no mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus. Neuropharmacol 1997, 36:265-267.
12. Ferraguti F., Conquet F., Corti C., Grandes P., Kuhn R., Knopfel T. Immunohistochemical localization of the mGluR1beta metabotropic glutamate receptor in the adult rodent forebrain: evidence for a differential distribution of mGluR1 splice variants. J. Comp. Neurol. 1998, 400:391-407.
13. Fong D.K., Rao A., Crump F.T., Craig A.M. Rapid synaptic remodeling by protein kinase C: reciprocal translocation of NMDA receptors and calcium/calmodulin-dependent kinase II. J. Neurosci. 2002, 22:2153-2164.
14. Lan J.Y., Skeberdis V.A., Jover T., Grooms S.Y., Lin Y., Araneda R.C., Zheng X., Bennett M.V., Zukin R.S. Protein kinase C modulates NMDA receptor trafficking and gating. Nat. Neurosci. 2001, 4:382-390.
15. Lu W.Y., Xiong Z.G., Lei S., Orser B.A., Dudek E., Browning M.D., MacDonald J.F. G-protein-coupled receptors act via protein kinase C and Src to regulate NMDA receptors. Nat. Neurosci. 1999, 2:331-338.
16. Lujan R., Nusser Z., Roberts J.D., Shigemoto R., Somogyi P. Perisynaptic location of metabotropic glutamate receptors mGluR1 and mGluR5 on dendrites and dendritic spines in the rat hippocampus. Eur. J. Neurosci. 1996, 8:1488-1500.
17. Lujan R., Roberts J.D., Shigemoto R., Ohishi H., Somogyi P. Differential plasma membrane distribution of metabotropic glutamate receptors mGluR1 alpha, mGluR2 and mGluR5, relative to neurotransmitter release sites. J. Chem. Neuroanat. 1997, 13:219-241.
18. Mannaioni G., Marino M.J., Valenti O., Traynelis S.F., Conn P.J. Metabotropic glutamate receptors 1 and 5 differentially regulate CA1 pyramidal cell function. J. Neurosci. 2001, 21:5925-5934.
19. Markram H., Segal M. Activation of protein kinase C suppresses responses to NMDA in rat CA1 hippocampal neurones. J. Physiol. 1992, 457:491-501.
20. Matus A.I., Taff-Jones D.H. Morphology and molecular composition of isolated postsynaptic junctional structures. Proc. R. Soc. Lond. B. Biol. Sci. 1978, 203:135-151.
21. Nakanishi S. Molecular diversity of glutamate receptors and implications for brain function. Science 1992, 258:597-603.
22. Pin J.P., Duvoisin R. The metabotropic glutamate receptors: structure and functions. Neuropharmacol 1995, 34:1-26.
23. Rao A.M., Hatcher J.F., Dempsey R.J. Neuroprotection by group I metabotropic glutamate receptor antagonists in forebrain ischemia of gerbil. Neurosci. Lett. 2000, 293:1-4.
24. Sanchez-Perez A.M., Felipo V. Serines 890 and 896 of the NMDA receptor subunit NR1 are differentially phosphorylated by protein kinase C isoforms. Neurochem. Int. 2005, 47:84-91.
25. Schoepp D.D., Conn P.J. Metabotropic glutamate receptors in brain function and pathology. Trends Pharmacol. Sci. 1993, 14:13-20.
26. Scott D.B., Blanpied T.A., Swanson G.T., Zhang C., Ehlers M.D. An NMDA receptor ER retention signal regulated by phosphorylation and alternative splicing. J. Neurosci. 2001, 21:3063-3072.
27. Scott D.B., Blanpied T.A., Ehlers M.D. Coordinated PKA and PKC phosphorylation suppresses RXR-mediated ER retention and regulates the surface delivery of NMDA receptors. Neuropharmacol 2003, 45:755-767.
28. Takagi N., Logan R., Teves L., Wallace M.C., Gurd J.W. Altered interaction between PSD-95 and the NMDA receptor following transient global ischemia. J. Neurochem. 2000, 74:169-178.
29. Takagi N., Sasakawa K., Besshoh S., Miyake-Takagi K., Takeo S. Transient ischemia enhances tyrosine phosphorylation and binding of the NMDA receptor to the Src homology 2 domain of phosphatidylinositol 3-kinase in the rat hippocampus. J. Neurochem. 2003, 84:67-76.
30. Tingley W.G., Ehlers M.D., Kameyama K., Doherty C., Ptak J.B., Riley C.T., Huganir R.L. Characterization of protein kinase A and protein kinase C phosphorylation of the N-methyl-d-aspartate receptor NR1 subunit using phosphorylation site-specific antibodies. J. Biol. Chem. 1997, 272:5157-5166.