Pyruvate: Ferredoxin oxidoreductase and thioredoxin reductase are involved in 5-nitroimidazole activation while flavin metabolism is linked to 5-nitroimidazole resistance in Giardia lamblia

Journal of Antimicrobial Chemotherapy

Volumn 66, Issue 8, 2011, Pages 1756-1765

  Leitsch, David ^a   Burgess, Anita G ^b   Dunn, Linda A ^b   Krauer, Kenia G ^b   Tan, Kevin ^c   Ducĥne, Michael ^a   Upcroft, Peter ^b   Eckmann, Lars ^d   Upcroft, Jacqueline A ^b  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Blastocystis; Metronidazole; NADPH oxidase; Ronidazole; Tinidazole

Indexed keywords

4 NITROIMIDAZOLE; FLAVINE MONONUCLEOTIDE; METRONIDAZOLE; PYRUVATE SYNTHASE; QUERCETIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RONIDAZOLE; THIOREDOXIN REDUCTASE; TINIDAZOLE;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; DOWN REGULATION; DRUG ACTIVATION; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME METABOLISM; GIARDIA LAMBLIA; PROTEIN EXPRESSION; PROTOZOON; TRICHOMONAS VAGINALIS;

ANTIPROTOZOAL AGENTS; DRUG RESISTANCE; FLAVINS; GIARDIA LAMBLIA; HUMANS; METABOLISM; NITROIMIDAZOLES; PYRUVATE SYNTHASE; THIOREDOXIN-DISULFIDE REDUCTASE;

EID: 79960472745     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkr192     Document Type: Article

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