Synthesis and electrochemistry of 2-ethenyl and 2-ethanyl derivatives of 5-nitroimidazole and antimicrobial activity against Giardia lamblia

Journal of Medicinal Chemistry

Volumn 52, Issue 13, 2009, Pages 4038-4053

  Valdez, Carlos A ^a   Tripp, Jonathan C ^a   Miyamoto, Yukiko ^b   Kalisiak, Jaroslaw ^a   Hruz, Petr ^b   Andersen, Yolanda S ^b   Brown, Sabrina E ^c   Kangas, Karina ^c   Arzu, Leo V ^c   Davids, Barbara J ^b   Gillin, Frances D ^b   Upcroft, Jacqueline A ^d   Upcroft, Peter ^d   Fokin, Valery V ^a   Smith, Diane K ^c   Sharpless, K Barry ^a   Eckmann, Lars ^b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c SAN DIEGO STATE UNIVERSITY   (United States)

^d QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

1 (1 METHYL 5 NITRO 1H IMIDAZOL 2 YL) 2 (4 METHYLPHENYL)ETHANE 1,2 DIYL DIACETATE; 1 (4 BROMOPHENYL) 2 (1 METHYL 5 NITRO 1H IMIDAZOL 2 YL)ETHANE 1,2 DIOL; 1 METHYL 2 [2 (1 METHYL 1H IMIDAZOL 2 YL)VINYL] 5 NITRO 1H IMIDAZOLE; 1 METHYL 2 [2 (2 METHYLPHENYL)VINYL] 5 NITRO 1H IMIDAZOLE; 1 METHYL 2 [2 (2,4,6 TRIMETHYLPHENYL)VINYL] 5 NITRO 1H IMIDAZOLE; 1 METHYL 2 [2 (3 METHYLPHENYL)VINYL] 5 NITRO 1H IMIDAZOLE; 1 METHYL 2 [2 (4 METHYLPHENYL)VINYL] 5 NITRO 1H IMIDAZOLE; 1 METHYL 2 [2 (4METHYLPHENYL)ETHYL] 5 NITRO 1H IMIDAZOLE; 1 METHYL 5 NITRO 2 (2 PHENYLETHYL) 1H IMIDAZOLE; 1 METHYL 5 NITRO 2 (2 PHENYLVINYL) 1H IMIDAZOLE; 1 METHYL 5 NITRO 2 [2 (3 THIENYL)VINYL] 1H IMIDAZOLE; 1 METHYL 5 NITRO 2 [2 [4 (TRIFLUOROMETHOXY)PHENYL]VINYL] 1H IMIDAZOLE; 2 (2 BIPHENYL 2 YLVINYL) 1 METHYL 5 NITRO 1H IMIDAZOLE; 2 [2 (2 BROMOPHENYL)VINYL] 1 METHYL 5 NITRO 1H IMIDAZOLE; 2 [2 (2 CHLOROPHENYL)VINYL] 1 METHYL 5 NITRO 1H IMIDAZOLE; 2 [2 (2 FURYL)VINYL] 1 METHYL 5 NITRO 1H IMIDAZOLE; 2 [2 (2 IODOPHENYL)VINYL] 1 METHYL 5 NITRO 1H IMIDAZOLE; 2 [2 (2,4 DICHLOROPHENYL)VINYL] 1 METHYL 5 NITRO 1H IMIDAZOLE; 2 [2 (3 BROMOPHENYL)VINYL] 1 METHYL 5 NITRO 1H IMIDAZOLE; 2 [2 (3 CHLOROPHENYL)VINYL] 1 METHYL 5 NITRO 1H IMIDAZOLE; 2 [2 (3 FLUOROPHENYL)VINYL] 1 METHYL 5 NITRO 1H IMIDAZOLE; 2 [2 (3 IODOPHENYL)VINYL] 1 METHYL 5 NITRO 1H IMIDAZOLE; 2 [2 (3 METHOXYPHENYL)VINYL] 1 METHYL 5 NITRO 1H IMIDAZOLE; 2 [2 (3A,7A DIHYDRO 1,3 BENZODIOXOL 5 YL)VINYL] 1 METHYL 5 NITRO 1H IMIDAZOLE; 2 [2 (4 BROMOPHENYL)ETHYL] 1 METHYL 5 NITRO 1H IMIDAZOLE; 2 [2 (4 BROMOPHENYL)VINYL] 1 METHYL 5 NITRO 1H IMIDAZOLE; 2 [2 (4 CHLOROPHENYL)VINYL] 1 METHYL 5 NITRO 1H IMIDAZOLE; 5 NITROIMIDAZOLE DERIVATIVE; METRONIDAZOLE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC RESISTANCE; ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYCLIC POTENTIOMETRY; CYTOTOXICITY; DOSE RESPONSE; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROCHEMISTRY; ELECTRON TRANSPORT; GIARDIA LAMBLIA; GIARDIASIS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; OXIDATION REDUCTION REACTION;

ANIMALS; ANTIPROTOZOAL AGENTS; DRUG DISCOVERY; DRUG RESISTANCE; ELECTROCHEMICAL TECHNIQUES; GIARDIA LAMBLIA; GIARDIASIS; METRONIDAZOLE; NITROIMIDAZOLES; OXIDATION-REDUCTION;

EID: 67649983429     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900356n     Document Type: Article

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