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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 15, 2011, Pages 4409-4415

Azepanone-based inhibitors of human cathepsin S: Optimization of selectivity via the P2 substituent

(15) Kerns, Jeffrey K a Nie, Hong a Bondinell, William a Widdowson, Katherine L a Yamashita, Dennis S a,b Rahman, Attiq a Podolin, Patricia L a Carpenter, Donald C a Jin, Qi a Riflade, Benoit a,c Dong, Xiaoyang a Nevins, Neysa a Keller, Paul M a Mitchell, Laura a,d Tomaszek, Thaddeus a

a GLAXOSMITHKLINE (United States)

b TREVENA INC (United States)

c Drexel University ISchool ^* (France)

d DREXEL UNIVERSITY (United States)

Author keywords

1 Methylcyclohexyl alanine; Azepanone; Cathepsin K; Cathepsin L; Cathepsin S; Cysteine protease

Indexed keywords

1 METHYLCYCLOHEXYL ALANINE; ALANINE DERIVATIVE; AZEPANONE INHIBITOR; CATHEPSIN K; CATHEPSIN L; CATHEPSIN S INHIBITOR; GLYCINE; NICOTINAMIDE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIGEN PRESENTATION; ARTICLE; CELL ACTIVITY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; HUMAN; HUMAN CELL; REACTION OPTIMIZATION; SEQUENCE HOMOLOGY;

EID: 79960382271 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.06.045 Document Type: Article

Times cited : (12)

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