Design of selective Cathepsin inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 16, 2009, Pages 4622-4625

  Bethel, Paul A ^a   Gerhardt, Stefan ^a   Jones, Emma V ^a   Kenny, Peter W ^a   Karoutchi, Galith I ^a   Morley, Andrew D ^a   Oldham, Keith ^a   Rankine, Neil ^a   Augustin, Martin ^b   Krapp, Stephan ^b   Simader, Hannes ^b   Steinbacher, Stefan ^b  

^a ASTRAZENECA   (United Kingdom)

^b PROTEROS BIOSTRUCTURES GMBH   (Germany)

Author keywords

Cathepsin; Cathepsin B; Cathepsin K; Cathepsin L; Cathepsin L2; Cathepsin S; Cathepsin V; Covalent inhibitor; Cysteine protease; Electrostatic; Hot spot; Hydrogen bond; Hydrogen bonding; Nitrile; Protein structure; Selectity; Structure based design; X ray crystallography

Indexed keywords

CATHEPSIN; CATHEPSIN INHIBITOR; ENZYME INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME INHIBITION; MOLECULAR RECOGNITION; STRUCTURE ACTIVITY RELATION;

CATHEPSINS; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 67749118106     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.06.090     Document Type: Article

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