Thioether acetamides as P3 binding elements for tetrahydropyrido-pyrazole cathepsin S inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 7, 2010, Pages 2379-2382

  Wiener, Danielle K ^a   Lee Dutra, Alice ^a   Bembenek, Scott ^a   Nguyen, Steven ^a   Thurmond, Robin L ^a   Sun, Siquan ^a   Karlsson, Lars ^a   Grice, Cheryl A ^a   Jones, Todd K ^a   Edwards, James P ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETAMIDE DERIVATIVE; AMIDE; CATHEPSIN S INHIBITOR; IMMUNOSUPPRESSIVE AGENT; PYRAZOLE DERIVATIVE; SULFIDE;

ARTICLE; BINDING SITE; CELL ACTIVITY; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; HYDROGEN BOND; SUBSTITUTION REACTION;

ACETAMIDES; CATHEPSINS; CELL LINE; HUMANS; MODELS, MOLECULAR; PROTEASE INHIBITORS; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP; SULFIDES;

EID: 77949490821     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.01.103     Document Type: Article

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