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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 15, 2011, Pages 4550-4555

Discovery of imidazo[1,2-b]pyridazines as IKKβ inhibitors. Part 3: Exploration of effective compounds in arthritis models

(11) Shimizu, Hiroki a Yamasaki, Tomonori a Yoneda, Yoshiyuki a Muro, Fumihito a Hamada, Tomoaki a Yasukochi, Takanori a Tanaka, Shinji a Toki, Tadashi a Yokoyama, Mika a Morishita, Kaoru a Iimura, Shin a

a DAIICHI SANKYO CO (Japan)

Author keywords

Collagen induced arthritis; IKK; Imidazo 1,2 b pyridazine; Inhibitor; Pharmacokinetic; TNF

Indexed keywords

ANTIINFLAMMATORY AGENT; I KAPPA B KINASE INHIBITOR; IMIDAZO[1,2 B]PYRIDAZINE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; COLLAGEN INDUCED ARTHRITIS; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; FEMALE; MALE; MOUSE; NONHUMAN; PAW EDEMA; PHARMACOLOGICAL BLOCKING; PHYSICOCHEMICAL MODEL; RAT;

ADMINISTRATION, ORAL; ANIMALS; ARTHRITIS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; I-KAPPA B KINASE; IMIDAZOLES; MICE; PROTEIN KINASE INHIBITORS; PYRIDAZINES; RATS; TUMOR NECROSIS FACTOR-ALPHA;

MUS; RATTUS;

EID: 79960359509 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.05.115 Document Type: Article

Times cited : (23)

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