Mechanisms of pyrazinamide resistance in mycobacteria: Importance of lack of uptake in addition to lack of pyrazinamidase activity

Microbiology

Volumn 145, Issue 6, 1999, Pages 1359-1367

  Raynaud, Catherine ^a   Lanéelle, Marie Antoinette ^a   Senaratne, Ryan H ^b   Draper, Philip ^b   Lanéelle, Gilbert ^a   Daffé, Mamadou ^a  

^a INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

Mycobacterium; Nicotinamide; Pyrazinamidase; Pyrazinamide; Tuberculosis

Indexed keywords

ARSENIC ACID; BACTERIAL ENZYME; CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE; CYTOSINE; ISONIAZID; LIPOSOME; NICOTINAMIDE; PYRAZINAMIDE; TUBERCULOSTATIC AGENT; VALINOMYCIN;

ANTIBIOTIC RESISTANCE; ARTICLE; BILAYER MEMBRANE; DRUG DIFFUSION; DRUG UPTAKE; ENZYME ACTIVITY; LOW TEMPERATURE; MYCOBACTERIUM AVIUM; MYCOBACTERIUM BOVIS; MYCOBACTERIUM KANSASII; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEOLIPOSOME;

ACTINOBACTERIA (CLASS); BACILLI; BACTERIA (MICROORGANISMS); CORYNEBACTERINEAE; MYCOBACTERIUM; MYCOBACTERIUM AVIUM; MYCOBACTERIUM BOVIS BCG; MYCOBACTERIUM KANSASII; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; UNCULTURED ACTINOMYCETE;

EID: 0043284551     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/13500872-145-6-1359     Document Type: Article

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