Efflux pump of the proton antiporter family confers low-level fluoroquinolone resistance in Mycobacterium smegmatis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 1, 1996, Pages 362-366

  Takiff, H E ^a   Cimino, M ^a   Musso, M C ^a   Weisbrod, T ^b   Martinez, R ^a   Delgado, M B ^a   Salazar, L ^a   Bloom, B R ^b   Jacobs Jr , W R ^b  

^a INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACRIFLAVINE; BENZALKONIUM CHLORIDE; CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE; CHLORAMPHENICOL; CIPROFLOXACIN; DOUBLE STRANDED DNA; ETHIDIUM BROMIDE; LEVOFLOXACIN; NALIDIXIC ACID; OFLOXACIN; PLASMID DNA; QUATERNARY AMMONIUM DERIVATIVE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SINGLE STRANDED DNA; SITAFLOXACIN; SPARFLOXACIN; TETRACYCLINE;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GROWTH; DNA SEQUENCE; GENE EXPRESSION; GENE MUTATION; GENETIC MODEL; MULTIDRUG RESISTANCE; MYCOBACTERIUM SMEGMATIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; STRAIN DIFFERENCE; TUBERCULOSIS; TUBERCULOSIS CONTROL;

AMINO ACID SEQUENCE; ANTI-INFECTIVE AGENTS; ANTIPORTERS; BACTERIAL PROTEINS; BIOLOGICAL TRANSPORT, ACTIVE; CARRIER PROTEINS; CIPROFLOXACIN; DRUG RESISTANCE, MICROBIAL; GENES, BACTERIAL; HYDROGEN-ION CONCENTRATION; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM; PLASMIDS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID;

BACTERIA (MICROORGANISMS); MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; STAPHYLOCOCCUS AUREUS; STREPTOMYCES; STREPTOMYCES GLAUCESCENS;

EID: 0030058375     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.1.362     Document Type: Article

References (43)

1. Fischl, M. A., Daikos, G. L., Uttamchadani, R. B., Poblete, R. B., Moreno, J. N., Reyes, R. R., Boota, A. M., Thompson, L. M., Cleary, S. A., Oldham, S. A., Saldana, M. J. & Lai, S. (1992) Ann. Intern. Med. 117, 184-190.
2. Heiflets, L. B. (1994) Semin. Respir. Infect. 9, 84-103.
3. Hooper, D. C. & Wolfson, J. S. (1991) N. Engl. J. Med. 324, 384-394.
4. Sullivan, E. A., Kreiswirth, B., Palumbo, L., Kapur, V., Musser, J., Ebrahimzadeh, A. & Frieden, T. R. (1995) Lancet 365, 1148-1150.
5. Takiff, H. E., Salazar, L., Guerrero, C., Philipp, W., Huang, W. M., Kreiswirth, B., Cole, S. T., Jacobs, W. R., Jr. & Telenti, A. (1994) Antimicrob. Agents Chemother. 38, 773-880.
6. Wang, J. C. (1985) Annu. Rev. Biochem. 54, 665-697.
7. Kato, J., Suzuki, H. & Ikeda H. (1992) J. Biol. Chem. 267, 25676-25684.
8. Adams, D. E., Shekhtman, E. M., Zechiedrich, E. L., Schmid, M. B. & Cozzarelli, N. R. (1992) Cell 71, 277-288.
9. Belland, R. J, Morrison, S. G., Ison, C. & Huang, W. M. (1994) Mol. Microbiol. 14, 371-380.
10. Ferrerro, L., Cameron, B., Manse, B., Langneauz, D., Crouzet, J., Famechon, A. & Blanche, F. (1994) Mol. Microbiol. 13, 641-653.
11. Yoshida, H., Bogaki, M., Nakamura, M., Yamanaka, L. M. & Nakamura, S. (1991) Antimicrob. Agents Chemother. 35, 1647-1650.
12. Hooper, D. C., Wolfson, J. S. (1993) Quinolone Antimicrobial Agents (Am. Soc. of Microbiol. Washington, DC), pp. 97-118.
13. Heisig, P. & Tschorney, R. (1994) Antimicrob. Agents Chemother. 38, 1284-1291.
14. Nakaido, H. (1994) Science 264, 382-387.
15. Hooper, D. C. Wolfson, J. S., Ng, E. Y. & Swartz, M. N. (1987) Am. J. Med. 82, Suppl. 4A, 12-20.
16. Hirai, K., Aoyama, H., Suzue, S., Irikura, T., Iyobe, S. & Mitsuhashi, S. (1986) Antimicrob. Agents Chemother. 30, 248-353.
17. Yoshida, H., Bogaki, M., Nakamura, S., Ubukata, K. & Konno, M. (1990) J. Bacteriol. 172, 6942-6949.
18. Levy, S. B. (1992) Antimicrob. Agents Chemother. 36, 695-703.
19. Lewis, K. (1994) Trends Biochem. 19, 119-124.
20. Neyfakh, A. A., Bidnenko, V. E. & Chen, L. B. (1991) Proc. Natl. Acad. Sci, USA 88, 4781-4785.
21. Ng, E. Y. W., Trucksis, M. & Hooper, D. C. (1994) Antimicrob. Agents Chemother. 38, 1345-1355.
22. Cohen, S. P., Hächler, H. & Levy, S. B. (1993) J. Bacteriol. 175, 1484-1492.
23. Miller, P. R., Gambino, L. F., Sulavik, M. C. & Gracheck, S. J. (1994) Antimicrob. Agents Chemother. 38, 1773-1779.
24. Ishida, H., Fuziware, H., Kaibori, Y., Horiuchi, T., Sato, K. & Osada, Y. (1995) Antimicrob. Agents Chemother. 39, 453-457.
25. Jacobs, W. R. Jr., Kalpana, G. V., Cirillo, J. D., Pascopella, L. Snapper, S. B., Udani, R. A., Jones, W., Barletta, R. G. & Bloom, B. R. (1991) Methods Enzymol. 204, 537-555.
26. Stover, C. K., de la Cruz, V. F., Fuerst, T. R., Burlein J. E., Benson, L. A., Bennett, L. T., Bansal, G. P., Young, J. F., Lee, M. H., Hatfull, G. F., Snapper, S. B., Barletta, R. G., Jacobs, W. R., Jr., & Bloom, B. R. (1991) Nature (London) 351, 456-460.
27. Ausubel, F. M., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. G., Smith, J. A. & Struhl, K. (1992) Short Protocols in Molecular Biology (Wiley, New York).
28. Donnelly-Wu, M. K., Jacobs, W. R., Jr., & Hatfull, G. F. (1993) Mol. Microbiol. 7, 407-417.
29. Altschul, S. F., Gisg, W., Miller, W., Myers, E. W. & Lipman, D. J. (1990) J. Mol. Biol. 215, 403-410.
30. Rouch, D. A., Cram, D. S., DiBerardino, D., Littlejohn, T. G. & Skurray, R. A. (1990) Mol. Microbiol. 4, 2051-2062.
31. Fernandez-Moreno, M. A., Caballero, J. L., Hopwood, D. A. & Malpartida, F. (1991) Cell 66, 769-780.
32. Decker, H., Montamedi, H. & Hutchinson, C. R. (1993) J. Bacteriol. 175, 3876-3886.
33. Neal, R. J. & Chater, K. F. (1987) Gene 58, 229-241.
34. Ehrenhofer-Murray, P. & Wurgler, F E. (1994) Mol. Gen. Genet. 244, 287-294.
35. Lomovskaya, O. & Lewis, K. (1992) Proc. Natl. Acad. Sci. USA 89, 8938-8942.
36. Strohl, W. R. (1992) Nucleic Acids Res. 20, 961-974.
37. Silver, L. L. & Bostian, K. A. (1993) Anttimicrob. Agents Chemother. 37, 377-383.
38. Gocke, E. (1991) Mutat. Res. 248, 135-143.
39. Li, X.-Z., Livermore, D. M. & Nikaido, H. (1994) Antimicrob. Agents Chemother. 38, 1732-1741.
40. Jarlier, V. & Nikaido, H. (1994) FEMS Microbiol. Lett. 123, 11-18.
41. Trucksis, M., Hooper, D. C. & Wolfson, J. S. (1991) Ann. Intern. Med. 114, 424-425.
42. Ball, P. (1990) J. Antimicrob. Chemother. 26 (Suppl. F), 165-179.
43. Ma, D., Cook, N., Hearst, J. E. & Nikaido, H. (1994) Trends Microbiol. 2, 489-493.