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Volumn 17, Issue 25, 2011, Pages 3043-3048

P16 gene hypermethylation and hepatocellular carcinoma: A systematic review and meta-analysis

Author keywords

Hepatocellular carcinoma; Liver cirrhosis; Meta analysis; Odds ratio; P16 hypermethylation

Indexed keywords

PROTEIN P16;

EID: 79960257770     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v17.i25.3043     Document Type: Review
Times cited : (50)

References (33)
  • 3
    • 0030733924 scopus 로고    scopus 로고
    • Molecular mechanism of hepatocarcinogenesis
    • Sheu JC. Molecular mechanism of hepatocarcinogenesis. J Gastroenterol Hepatol 1997; 12: S309-S313
    • (1997) J Gastroenterol Hepatol , vol.12
    • Sheu, J.C.1
  • 4
    • 0028275733 scopus 로고
    • Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers
    • Nobori T, Miura K, Wu DJ, Lois A, Takabayashi K, Carson DA. Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature 1994; 368: 753-756
    • (1994) Nature , vol.368 , pp. 753-756
    • Nobori, T.1    Miura, K.2    Wu, D.J.3    Lois, A.4    Takabayashi, K.5    Carson, D.A.6
  • 6
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • Sherr CJ. Cancer cell cycles. Science 1996; 274: 1672-1677
    • (1996) Science , vol.274 , pp. 1672-1677
    • Sherr, C.J.1
  • 7
    • 0031043705 scopus 로고    scopus 로고
    • Frequency of mutation and deletion of the tumor suppressor gene CDKN2A (MTS1/p16) in hepatocellular carcinoma from an Australian population
    • Biden K, Young J, Buttenshaw R, Searle J, Cooksley G, Xu DB, Leggett B. Frequency of mutation and deletion of the tumor suppressor gene CDKN2A (MTS1/p16) in hepatocellular carcinoma from an Australian population. Hepatology 1997; 25: 593-597
    • (1997) Hepatology , vol.25 , pp. 593-597
    • Biden, K.1    Young, J.2    Buttenshaw, R.3    Searle, J.4    Cooksley, G.5    Xu, D.B.6    Leggett, B.7
  • 8
    • 79953769654 scopus 로고    scopus 로고
    • Reprint-- preferred reporting items for systematic reviews and metaanalyses: The PRISMA statement
    • Moher D, Liberati A, Tetzlaff J, Altman DG. Reprint-- preferred reporting items for systematic reviews and metaanalyses: the PRISMA statement. Phys Ther 2009; 89: 873-880
    • (2009) Phys Ther , vol.89 , pp. 873-880
    • Moher, D.1    Liberati, A.2    Tetzlaff, J.3    Altman, D.G.4
  • 9
    • 84942475903 scopus 로고
    • The Cochrane Collaboration. Preparing, maintaining, and disseminating systematic reviews of the effects of health care
    • Bero L, Rennie D. The Cochrane Collaboration. Preparing, maintaining, and disseminating systematic reviews of the effects of health care. JAMA 1995; 274: 1935-1938
    • (1995) JAMA , vol.274 , pp. 1935-1938
    • Bero, L.1    Rennie, D.2
  • 12
    • 0028659004 scopus 로고
    • Operating characteristics of a rank correlation test for publication bias
    • Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics 1994; 50: 1088-1101
    • (1994) Biometrics , vol.50 , pp. 1088-1101
    • Begg, C.B.1    Mazumdar, M.2
  • 13
    • 0030922816 scopus 로고    scopus 로고
    • Bias in meta-analysis detected by a simple, graphical test
    • Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997; 315: 629-634
    • (1997) BMJ , vol.315 , pp. 629-634
    • Egger, M.1    Davey Smith, G.2    Schneider, M.3    Minder, C.4
  • 14
    • 77957149560 scopus 로고    scopus 로고
    • Comparative analysis of promoter methylation and gene expression endpoints between tumorous and nontumorous tissues from HCV-positive patients with hepatocellular carcinoma
    • Formeister EJ, Tsuchiya M, Fujii H, Shpyleva S, Pogribny IP, Rusyn I. Comparative analysis of promoter methylation and gene expression endpoints between tumorous and nontumorous tissues from HCV-positive patients with hepatocellular carcinoma. Mutat Res 2010; 692: 26-33
    • (2010) Mutat Res , vol.692 , pp. 26-33
    • Formeister, E.J.1    Tsuchiya, M.2    Fujii, H.3    Shpyleva, S.4    Pogribny, I.P.5    Rusyn, I.6
  • 15
    • 74049130932 scopus 로고    scopus 로고
    • Hepatitis B virus X protein induces hypermethylation of p16(INK4A) promoter via DNA methyltransferases in the early stage of HBV-associated hepatocarcinogenesis
    • Zhu YZ, Zhu R, Fan J, Pan Q, Li H, Chen Q, Zhu HG. Hepatitis B virus X protein induces hypermethylation of p16(INK4A) promoter via DNA methyltransferases in the early stage of HBV-associated hepatocarcinogenesis. J Viral Hepat 2010; 17: 98-107
    • (2010) J Viral Hepat , vol.17 , pp. 98-107
    • Zhu, Y.Z.1    Zhu, R.2    Fan, J.3    Pan, Q.4    Li, H.5    Chen, Q.6    Zhu, H.G.7
  • 16
    • 47249146077 scopus 로고    scopus 로고
    • CpG island methylator phenotype association with upregulated telomerase activity in hepatocellular carcinoma
    • Zhang C, Guo X, Jiang G, Zhang L, Yang Y, Shen F, Wu M, Wei L. CpG island methylator phenotype association with upregulated telomerase activity in hepatocellular carcinoma. Int J Cancer 2008; 123: 998-1004
    • (2008) Int J Cancer , vol.123 , pp. 998-1004
    • Zhang, C.1    Guo, X.2    Jiang, G.3    Zhang, L.4    Yang, Y.5    Shen, F.6    Wu, M.7    Wei, L.8
  • 17
    • 33845994601 scopus 로고    scopus 로고
    • Correlations of CpG island methylator phenotype and OPCML gene methylation to carcinogenesis of hepatocellular carcinoma
    • Liu WJ, Wang L, Wang JP, Li JQ, Zhang CQ, Zheng L, Yuan YF. [Correlations of CpG island methylator phenotype and OPCML gene methylation to carcinogenesis of hepatocellular carcinoma]. Ai Zheng 2006; 25: 696-700
    • (2006) Ai Zheng , vol.25 , pp. 696-700
    • Liu, W.J.1    Wang, L.2    Wang, J.P.3    Li, J.Q.4    Zhang, C.Q.5    Zheng, L.6    Yuan, Y.F.7
  • 18
    • 4444375661 scopus 로고    scopus 로고
    • Association of low p16INK4a and p15INK4b mRNAs expression with their CpGislands methylation with human hepatocellular carcinogenesis
    • Qin Y, Liu JY, Li B, Sun ZL, Sun ZF. Association of low p16INK4a and p15INK4b mRNAs expression with their CpGislands methylation with human hepatocellular carcinogenesis. World J Gastroenterol 2004; 10: 1276-1280
    • (2004) World J Gastroenterol , vol.10 , pp. 1276-1280
    • Qin, Y.1    Liu, J.Y.2    Li, B.3    Sun, Z.L.4    Sun, Z.F.5
  • 19
    • 0141648473 scopus 로고    scopus 로고
    • Aberrant CpG island hypermethylation along multistep hepatocarcinogenesis
    • Lee S, Lee HJ, Kim JH, Lee HS, Jang JJ, Kang GH. Aberrant CpG island hypermethylation along multistep hepatocarcinogenesis. Am J Pathol 2003; 163: 1371-1378
    • (2003) Am J Pathol , vol.163 , pp. 1371-1378
    • Lee, S.1    Lee, H.J.2    Kim, J.H.3    Lee, H.S.4    Jang, J.J.5    Kang, G.H.6
  • 21
    • 0036789450 scopus 로고    scopus 로고
    • High frequency of promoter hypermethylation of RASSF1A and p16 and its relationship to aflatoxin B1-DNA adduct levels in human hepatocellular carcinoma
    • Zhang YJ, Ahsan H, Chen Y, Lunn RM, Wang LY, Chen SY, Lee PH, Chen CJ, Santella RM. High frequency of promoter hypermethylation of RASSF1A and p16 and its relationship to aflatoxin B1-DNA adduct levels in human hepatocellular carcinoma. Mol Carcinog 2002; 35: 85-92
    • (2002) Mol Carcinog , vol.35 , pp. 85-92
    • Zhang, Y.J.1    Ahsan, H.2    Chen, Y.3    Lunn, R.M.4    Wang, L.Y.5    Chen, S.Y.6    Lee, P.H.7    Chen, C.J.8    Santella, R.M.9
  • 22
    • 1542322897 scopus 로고    scopus 로고
    • Methylation profiling of twenty four genes and the concordant methylation behaviours of nineteen genes that may contribute to hepatocellular carcinogenesis
    • Yu J, Zhang HY, Ma ZZ, Lu W, Wang YF, Zhu JD. Methylation profiling of twenty four genes and the concordant methylation behaviours of nineteen genes that may contribute to hepatocellular carcinogenesis. Cell Res 2003; 13: 319-333
    • (2003) Cell Res , vol.13 , pp. 319-333
    • Yu, J.1    Zhang, H.Y.2    Ma, Z.Z.3    Lu, W.4    Wang, Y.F.5    Zhu, J.D.6
  • 23
    • 0033765496 scopus 로고    scopus 로고
    • Genetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosis--A comprehensive study of loss of heterozygosity and microsatellite instability at 39 loci and DNA hypermethylation on 8 CpG islands in microdissected specimens from patients with hepatocellular carcinoma
    • Kondo Y, Kanai Y, Sakamoto M, Mizokami M, Ueda R, Hirohashi S. Genetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosis--A comprehensive study of loss of heterozygosity and microsatellite instability at 39 loci and DNA hypermethylation on 8 CpG islands in microdissected specimens from patients with hepatocellular carcinoma. Hepatology 2000; 32: 970-979
    • (2000) Hepatology , vol.32 , pp. 970-979
    • Kondo, Y.1    Kanai, Y.2    Sakamoto, M.3    Mizokami, M.4    Ueda, R.5    Hirohashi, S.6
  • 24
    • 0035127794 scopus 로고    scopus 로고
    • Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis
    • Saito Y, Kanai Y, Sakamoto M, Saito H, Ishii H, Hirohashi S. Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis. Hepatology 2001; 33: 561-568
    • (2001) Hepatology , vol.33 , pp. 561-568
    • Saito, Y.1    Kanai, Y.2    Sakamoto, M.3    Saito, H.4    Ishii, H.5    Hirohashi, S.6
  • 25
    • 0033818628 scopus 로고    scopus 로고
    • Frequent p15 promoter methylation in tumor and peripheral blood from hepatocellular carcinoma patients
    • Wong IH, Lo YM, Yeo W, Lau WY, Johnson PJ. Frequent p15 promoter methylation in tumor and peripheral blood from hepatocellular carcinoma patients. Clin Cancer Res 2000; 6: 3516-3521
    • (2000) Clin Cancer Res , vol.6 , pp. 3516-3521
    • Wong, I.H.1    Lo, Y.M.2    Yeo, W.3    Lau, W.Y.4    Johnson, P.J.5
  • 27
    • 79960254912 scopus 로고    scopus 로고
    • Detection and significance of p16 and its methylation in primary hepatocellular carcinoma
    • Zhang YL, Xiao WH, Zhang YM, Liang HJ. Detection and significance of p16 and its methylation in primary hepatocellular carcinoma. Disan Junyi Daxue Xuebao 2002; 24: 1182-1184
    • (2002) Disan Junyi Daxue Xuebao , vol.24 , pp. 1182-1184
    • Zhang, Y.L.1    Xiao, W.H.2    Zhang, Y.M.3    Liang, H.J.4
  • 31
    • 0034796736 scopus 로고    scopus 로고
    • Alteration of DNA methylation in gastrointestinal carcinogenesis
    • Fang JY, Xiao SD. Alteration of DNA methylation in gastrointestinal carcinogenesis. J Gastroenterol Hepatol 2001; 16: 960-968
    • (2001) J Gastroenterol Hepatol , vol.16 , pp. 960-968
    • Fang, J.Y.1    Xiao, S.D.2
  • 32
    • 1542273254 scopus 로고    scopus 로고
    • Detection of aberrant p16INK4A methylation in sera of patients with liver cirrhosis and hepatocellular carcinoma
    • Chu HJ, Heo J, Seo SB, Kim GH, Kang DH, Song GA, Cho M, Yang US. Detection of aberrant p16INK4A methylation in sera of patients with liver cirrhosis and hepatocellular carcinoma. J Korean Med Sci 2004; 19: 83-86
    • (2004) J Korean Med Sci , vol.19 , pp. 83-86
    • Chu, H.J.1    Heo, J.2    Seo, S.B.3    Kim, G.H.4    Kang, D.H.5    Song, G.A.6    Cho, M.7    Yang, U.S.8
  • 33
    • 41849142290 scopus 로고    scopus 로고
    • Molecular mechanism underlying the functional loss of cyclindependent kinase inhibitors p16 and p27 in hepatocellular carcinoma
    • Matsuda Y. Molecular mechanism underlying the functional loss of cyclindependent kinase inhibitors p16 and p27 in hepatocellular carcinoma. World J Gastroenterol 2008; 14: 1734-1740
    • (2008) World J Gastroenterol , vol.14 , pp. 1734-1740
    • Matsuda, Y.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.