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Volumn 19, Issue 1, 2004, Pages 83-86

Detection of Aberrant p16INK4A Methylation in Sera of Patients with Liver Cirrhosis and Hepatocellular Carcinoma

Author keywords

Carcinoma hepatocellular; Liver cirrhosis; p16INK4a methylation; PCR methylation specific

Indexed keywords

ALPHA FETOPROTEIN; PROTEIN P16; TUMOR MARKER; DNA; PROTEIN P16INK4A;

EID: 1542273254     PISSN: 10118934     EISSN: None     Source Type: Journal    
DOI: 10.3346/jkms.2004.19.1.83     Document Type: Article
Times cited : (36)

References (26)
  • 2
    • 0025356304 scopus 로고
    • Percutaneous ethanol injection therapy for treatment of hepatocellular carcinoma
    • Shiina S, Tagawa K, Unuma T, Terano A Percutaneous ethanol injection therapy for treatment of hepatocellular carcinoma. Am J Reontgenol 1990; 154: 947-51.
    • (1990) Am J Reontgenol , vol.154 , pp. 947-951
    • Shiina, S.1    Tagawa, K.2    Unuma, T.3    Terano, A.4
  • 3
    • 0032857003 scopus 로고    scopus 로고
    • Local ablation therapy for hepatocellular carcinoma
    • Okuda S. Local ablation therapy for hepatocellular carcinoma. Semin Liver Dis 1999; 19: 323-8.
    • (1999) Semin Liver Dis , vol.19 , pp. 323-328
    • Okuda, S.1
  • 4
    • 0033960899 scopus 로고    scopus 로고
    • Early detection of hepatocellular carcinoma increases the chance of treatment: Hong Kong experience
    • Yuen MF, Cheng CC, Lauder IJ, Lam SK, Ooi CG, Lai CL. Early detection of hepatocellular carcinoma increases the chance of treatment: Hong Kong experience. Hepatology 2000; 31: 330-5.
    • (2000) Hepatology , vol.31 , pp. 330-335
    • Yuen, M.F.1    Cheng, C.C.2    Lauder, I.J.3    Lam, S.K.4    Ooi, C.G.5    Lai, C.L.6
  • 7
    • 0028071555 scopus 로고
    • Mutation in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis
    • Greenblatt MS, Bennett WP, Hollstein M, Harris CC. Mutation in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 1994; 54: 4855-78.
    • (1994) Cancer Res , vol.54 , pp. 4855-4878
    • Greenblatt, M.S.1    Bennett, W.P.2    Hollstein, M.3    Harris, C.C.4
  • 8
    • 0033765496 scopus 로고    scopus 로고
    • Genetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosis: A comprehensive study of loss of heterozygosity and microsatellite instability at 39 loci and DNA hypermethylation on 8 CpG islands in microdissected specimens from patients with hepatocellular carcinoma
    • Kondo Y, Kanai Y, Sakamoto M, Mizokami M, Ueda R, Hirohashi S. Genetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosis: A comprehensive study of loss of heterozygosity and microsatellite instability at 39 loci and DNA hypermethylation on 8 CpG islands in microdissected specimens from patients with hepatocellular carcinoma. Hepatology 2000; 32: 970-9.
    • (2000) Hepatology , vol.32 , pp. 970-979
    • Kondo, Y.1    Kanai, Y.2    Sakamoto, M.3    Mizokami, M.4    Ueda, R.5    Hirohashi, S.6
  • 10
    • 0029011539 scopus 로고
    • 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
    • Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, Burger PC, Baylin SB, Sidransky D. 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat Med 1995; 1: 686-92.
    • (1995) Nat Med , vol.1 , pp. 686-692
    • Merlo, A.1    Herman, J.G.2    Mao, L.3    Lee, D.J.4    Gabrielson, E.5    Burger, P.C.6    Baylin, S.B.7    Sidransky, D.8
  • 11
    • 0027769876 scopus 로고
    • A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
    • Serrano M, Hannon GJ, Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 1993; 366: 704-7.
    • (1993) Nature , vol.366 , pp. 704-707
    • Serrano, M.1    Hannon, G.J.2    Beach, D.3
  • 12
    • 0036699940 scopus 로고    scopus 로고
    • Molecular pathogenesis of human hepatocellular carcinoma
    • Thorgeirsson SS, Grisham JW. Molecular pathogenesis of human hepatocellular carcinoma. Nat Genet 2002; 31: 339-46.
    • (2002) Nat Genet , vol.31 , pp. 339-346
    • Thorgeirsson, S.S.1    Grisham, J.W.2
  • 13
    • 0036216526 scopus 로고    scopus 로고
    • Genes involved in hepatocellular carcinoma: Deregulation in cell cycling and apoptosis
    • Tannapfel A, Wittekind C. Genes involved in hepatocellular carcinoma: deregulation in cell cycling and apoptosis. Virchows Arch 2002; 440: 345-52.
    • (2002) Virchows Arch , vol.440 , pp. 345-352
    • Tannapfel, A.1    Wittekind, C.2
  • 14
    • 0032168678 scopus 로고    scopus 로고
    • CpG methylation, chromatin structure and gene silencing: A three-way connection
    • Razin A. CpG methylation, chromatin structure and gene silencing: a three-way connection. EMBO J 1998; 17: 4905-7.
    • (1998) EMBO J , vol.17 , pp. 4905-4907
    • Razin, A.1
  • 15
    • 0032581149 scopus 로고    scopus 로고
    • Alterations of CDKN2 (MTS1/ p16INK4A) gene in paraffin-embedded tumor tissues of human stomach, lung, cervix and liver cancers
    • Kim JR, Kim SY, Kim MJ, Kim JH. Alterations of CDKN2 (MTS1/ p16INK4A) gene in paraffin-embedded tumor tissues of human stomach, lung, cervix and liver cancers. Exp Mol Med 1998; 30: 109-14.
    • (1998) Exp Mol Med , vol.30 , pp. 109-114
    • Kim, J.R.1    Kim, S.Y.2    Kim, M.J.3    Kim, J.H.4
  • 17
    • 0032189238 scopus 로고    scopus 로고
    • Infrequent mutations and no methylation of CDKN2A (p16/MTS1) and CDKN2B(p15/MTS2) in hepatocellular carcinoma in Taiwan
    • Lin YW, Chen CH, Huang GT, Lee PH, Wang JT, Chen DS, Lu FJ, Sheu JC. Infrequent mutations and no methylation of CDKN2A (p16/MTS1) and CDKN2B(p15/MTS2) in hepatocellular carcinoma in Taiwan. Eur J Cancer 1998; 34: 1789-95.
    • (1998) Eur J Cancer , vol.34 , pp. 1789-1795
    • Lin, Y.W.1    Ch, C.2    Huang, G.T.3    Lee, P.H.4    Wang, J.T.5    Chen, D.S.6    Lu, F.J.7    Sheu, J.C.8
  • 18
    • 0030900070 scopus 로고    scopus 로고
    • Germ-line mutations of the p16INK4 (MTS1) gene occur in a subset of patients with hepatocellular carcinoma
    • Chaubert P, Gayer R, Zimmermann A, Fontolliet C, Stamm B, Bosman F, Shaw P. Germ-line mutations of the p16INK4 (MTS1) gene occur in a subset of patients with hepatocellular carcinoma. Hepatology 1997; 25: 1376-81.
    • (1997) Hepatology , vol.25 , pp. 1376-1381
    • Chaubert, P.1    Gayer, R.2    Zimmermann, A.3    Fontolliet, C.4    Stamm, B.5    Bosman, F.6    Shaw, P.7
  • 23
    • 0034856294 scopus 로고    scopus 로고
    • EASL Panel of Experts on HCC. Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver
    • Bruix J, Sherman M, Llovet JM, Beaugrand M, Lencioni R, Burroughs AK, Christensen E, Pagliaro L, Colombo M, Rodes J, EASL Panel of Experts on HCC. Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver. J Hepatol 2001; 35: 421-30.
    • (2001) J Hepatol , vol.35 , pp. 421-430
    • Bruix, J.1    Sherman, M.2    Llovet, J.M.3    Beaugrand, M.4    Lencioni, R.5    Burroughs, A.K.6    Christensen, E.7    Pagliaro, L.8    Colombo, M.9    Rodes, J.10
  • 25
    • 0034637707 scopus 로고    scopus 로고
    • Quantitative comparison of alpha-fetoprotein and albumin mRNA levels in hepatocellular carcinoma/adenoma, non-tumor liver and blood: Implications in cancer detection and monitoring
    • Wong IH, Lau WY, Leung T, Johnson PJ. Quantitative comparison of alpha-fetoprotein and albumin mRNA levels in hepatocellular carcinoma/adenoma, non-tumor liver and blood: implications in cancer detection and monitoring. Cancer Lett 2000; 156: 141-9.
    • (2000) Cancer Lett , vol.156 , pp. 141-149
    • Wong, I.H.1    Lau, W.Y.2    Leung, T.3    Johnson, P.J.4
  • 26
    • 0033811555 scopus 로고    scopus 로고
    • Relationship of p16 methylation status and serum alpha-fetoprotein concentration in hepatocellular carcinoma patients
    • Wong IH, Lo YM, Lai PB, Johnson PJ. Relationship of p16 methylation status and serum alpha-fetoprotein concentration in hepatocellular carcinoma patients. Clin Chem 2000; 46: 1420-2.
    • (2000) Clin Chem , vol.46 , pp. 1420-1422
    • Wong, I.H.1    Lo, Y.M.2    Lai, P.B.3    Johnson, P.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.