Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): Synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/Cyclin A/meriolin complex

Journal of Medicinal Chemistry

Volumn 51, Issue 4, 2008, Pages 737-751

  Echalier, Aude ^a   Bettayeb, Karima ^b   Ferandin, Yoan ^b   Lozach, Olivier ^b   Clément, Monique ^c   Valette, Annie ^d   Liger, François ^e   Marquet, Bernard ^e   Morris, Jonathan C ^f   Endicott, Jane A ^a   Joseph, Benoît ^e   Meijer, Laurent ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b STATION BIOLOGIQUE   (France)

^c UNIVERSITÉ DE NANTES   (France)

^d Université de Toulouse Paul Sabatier   (France)

^e UNIVERSITÉ LYON 1   (France)

^f UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

3 (PYRIMIDIN 4 YL) 4 HYDROXY 1H PYRROLO[2,3 B]PYRIDINE; 3 [(2 AMINO)PYRIMIDIN 4 YL] 1H PYRROLO[2,3 B]PYRIDINE; 3 [(2 AMINO)PYRIMIDIN 4 YL] 4 (1 METHOXYETHOXY) 1H PYRROLO[2,3 B]PYRIDINE; 3 [(2 AMINO)PYRIMIDIN 4 YL] 4 (2 METHOXYETHOXY) 1H PYRROLO[2,3 B]PYRIDINE; 3 [(2 AMINO)PYRIMIDIN 4 YL] 4 CHLORO 1H PYRROLO[2,3 B]PYRIDINE; 3 [(2 AMINO)PYRIMIDIN 4 YL] 4 ETHOXY 1H PYRROLO[2,3 B]PYRIDINE; 3 [(2 AMINO)PYRIMIDIN 4 YL] 4 HYDROXY 1 METHYL 1H PYRROLO[2,3 B]PYRIDINE; 3 [(2 AMINO)PYRIMIDIN 4 YL] 4 HYDROXY 1H PYRROLO[2,3 B]PYRIDINE; 3 [(2 AMINO)PYRIMIDIN 4 YL] 4 METHOXY 1 METHYL 1H PYRROLO[2,3 B]PYRIDINE; 3 [(2 AMINO)PYRIMIDIN 4 YL] 4 METHOXY 1H PYRROLO[2,3 B]PYRIDINE; 3 [(2 AMINO)PYRIMIDIN 4 YL] 4 PROPOXY 1H PYRROLO[2,3 B]PYRIDINE; 3 [(2 AMINO)PYRIMIDIN 4 YL] 6 BROMO 1H PYRROLO[2,3 B]PYRIDINE; 3 [(2 METHYLSULFANYL)PYRIMIDIN 4 YL] 4 METHOXY 1H PYRROLO[2,3 B]PYRIDINE; 3 PYRIMIDIN 4 YL METHOXY 1H PYRROLO[2,3 B]PYRIDINE; CYCLIN A; CYCLIN DEPENDENT KINASE 2; MERIOLIN DERIVATIVE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DEGENERATIVE DISEASE; DRUG ACTIVITY; DRUG EFFICACY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; KIDNEY POLYCYSTIC DISEASE; MOLECULAR DYNAMICS; NEOPLASM; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; AZA COMPOUNDS; BICYCLO COMPOUNDS, HETEROCYCLIC; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; CYCLIN A; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE 9; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDOLES; MODELS, MOLECULAR; PYRIMIDINES; SPHEROIDS, CELLULAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 39749165071     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm700940h     Document Type: Article

References (88)