Reduction of large-conductance Ca2+-activated K+ channel with compensatory increase of nitric oxide in insulin resistant rats

Diabetes/Metabolism Research and Reviews

Volumn 27, Issue 5, 2011, Pages 461-469

  Shangjian, Li ^a   Zhengrong, Deng ^a   Liqiang, Wei ^a   Lei, Liang ^a   Wenting, Ai ^a   Xiling, Shou ^a   Xinyi, Chen ^a  

^a SHAANXI PROVINCIAL PEOPLE S HOSPITAL   (China)

Author keywords

1 subunit; Insulin resistance; Large conductance Ca2+ activated K+ channel; Nitric oxide; Patch clamp; Vascular smooth muscle cell

Indexed keywords

IBERIOTOXIN; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; MESSENGER RNA; NITRIC OXIDE;

ATHEROSCLEROSIS; BLOOD LEVEL; DIASTOLE; DOWN REGULATION; HYPERTENSION; INSULIN RESISTANCE; MESENTERIC ARTERY; MORTALITY; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; PREVALENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVIEW; SPRAGUE DAWLEY RAT; THORACIC AORTA; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING;

ANIMALS; AORTA, THORACIC; INSULIN RESISTANCE; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL BETA SUBUNITS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MALE; MESENTERIC ARTERIES; NITRIC OXIDE; PATCH-CLAMP TECHNIQUES; PEPTIDES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 79960153894     PISSN: 15207552     EISSN: 15207560     Source Type: Journal    
DOI: 10.1002/dmrr.1196     Document Type: Review

References (36)

1. Blann AD. Angiogenesis, the metabolic syndrome and heart disease: is there a connection? J Intern Med 2010; 268(4): 338-347.
2. Meigs JB, Wilson PWF, Nathan DM, D'Agostino RB, Williams K, Haffner SM. Prevalence and characteristics of the metabolic syndrome in the San Antonio Heart and Framingham offspring Studies. Diabetes 2003; 8: 2160-2167.
3. Jackson WF. Ion channels and vascular tone. Hypertension 2000; 35(1): 173-178.
4. Brenner R, Perez GJ, Bonev AD, et al. Vasoregulation by the β1 subunit of calcium-activated potassium channel. Nature 2000; 407: 870-876.
5. + channels: function, pharmacology and drugs. Curr Med Chem 2002; 9: 1385-1395.
6. + channels in small mesenteric artery mycoytes from spontaneously hypertensive rats compared to Wistar-Kyoto rats. Am J Hypertens 2003; 16(1): 21-27.
7. Bugiardini R, Manfrini O, Pizzi C, Fontana F, Morgagni G. Endothelial function predicts future development of coronary artery disease: a study of women with chest pain and normal coronary angiograms. Circulation 2004; 109(21): 2518-2523.
8. Shinozaki K, Kashiwagi A, Nishio Y, et al. Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O2-imbalance in insulin-resistant rat aorta. Diabetes 1999; 48(12): 2437-2445.
9. Zahedi AS, Ghasemi A, Azizi F. Serum nitric oxide metabolites in subjects with metabolic syndrome. Clin Biochem 2008; 41: 1342-1347.
10. Maejima K, Nakano S, Himeno M, et al. Increased basal levels of plasma nitric oxide in type 2 diabetic subjects. Relationship to microvascular complications. J Diabet Complications 2001; 15(3): 135-143.
11. Li SH, Xie XJ, Chen XY. The change of blood biochemical indicator in insulin resistance rats fed with high-fat and high-glucose diet. Shaanxi Med J 2010; 39(12): 1582-1583.
12. Lerman A, Zeiher AM. Endothelial function: cardiac events. Circulation 2005; 111: 363-368.
13. Madhu SV. Endothelial dysfunction and diabetes. J Assoc Physicians India 2010; 58: 475-476.
14. Ding H, Hashem M, Wiehler WB, et al. Endothelial dysfunction in the Streptozotocin-induced diabetic apoE-deficient mouse. Br J Pharmacol 2005; 146(8): 1110-1118.
15. Hsueh WA, Quinones MJ. Role of endothelial dysfunction in insulin resistance. Am J Cardiol 2003; 92: 10J-17J.
16. Brame L, Verma S, Anderson T, Lteif A, Mather K. Insulin resistance as a therapeutic target for improved endothelial function: metformin. Curr Drug Targets Cardiovasc Haematol Disord 2004; 4(1): 53-63.
17. Mather K, Anderson TJ, Verma S. Insulin action in the vasculature: physiology and pathophysiology. J Vasc Res 2001; 38: 415-422.
18. Potenza MA, Addabbo F, Montagnani M. Vascular actions of insulin with implications for endothelial dysfunction. Am J Physiol Endocrinol Metab 2009; 297(3): E568-E577.
19. Li H, Wallerath T, Munzel T, Fostermann U. Regulation of endothelial-type NO synthase expression in pathophysiology and in response to drugs. Nitric Oxide 2002; 7: 149-164.
20. Brillante DG, O'Sullivan AJ, Howes LG. Arterial stiffness in insulin resistance: the role of nitric oxide and angiotensin II receptors. Vasc Health Risk Manag 2009; 5(1): 73-78.
21. Woodman RJ, Playford DA, Watts GF. Basal production of nitric oxide (NO) and non-NO vasodilators in the forearm circulation in type 2 diabetes: associations with blood pressure and HDL cholesterol. Diabetes Res Clin Pract 2006; 71(1): 59-67.
22. Bolotina VM, Najibi S, Palacino JJ, Pagano PJ, Cohen RA. Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle. Nature 1994; 368(6474): 850-853.
23. Ca channel expression in mammalian cells by direct phosphorylation at serine. J Biol Chem 1999; 274: 10927-10935.
24. Kim KY, Cheon HG. Antiangiogenic effect of rosiglitazone is mediated via peroxisome proliferators-activated receptor γ-activated maxi-K channel opening in human umbilical vein endothelial cells. J Biol Chem 2006; 281: 13503-13512.
25. Birgit E, Dobromir D. Vascular large conductance calcium-activated potassium channels: functional role and therapeutic potential. Naunyn-Schmiedeberg's Arch Pharmacol 2007; 376: 145-155.
26. Ledoux J, Werner ME, Brayden JE, Nelson MT. Calcium-activated potassium channels and the regulation of vascular tone. Physiology 2006; 21: 69-78.
27. 2+ and voltage. Biol Res 2006; 39: 385-401.
28. Knaus HG, Garcia-Calvo M, Kaczorowski GJ, Garcia ML. Subunit composition of the high conductance calcium-activated potassium channel from smooth muscle, a representative of the mSlo and slowpoke family of potassium channels. J Biol Chem 1994; 269(6): 3921-3924.
29. Gutterman DD, Miura H, Liu Y. Redox modulation of vascular tone focus of potassium channel mechanisms of dilation. Arterioscler Thromb Vasc Biol 2005; 25: 274-278.
30. Amberg GC, Santana LF. Downregulation of the BK channel beta1 subunit in genetic hypertension. Circ Res 2003; 93: 965-971.
31. Nieves-Cintron M, Amberg GC, Nichols CB, Molkentin JD, Santana LF. Activation of NFATC3 down-regulates the beta 1 subunit of large conductance, calcium-activated K-channels in arterial smooth muscle and contributes to hypertension. J Biol Chem 2007; 282: 3231-3240.
32. + channel in sphincter of oddi cells from rabbits fed with a high cholesterol diet. Acta Biochim Biophys Sin 2006; 38(12): 893-899.
33. 2+-activated potassium β1 channel subunit in retinal arteriolar smooth muscle. Circ Res 2007; 100(5): 703-711.
34. + channels in cerebral artery smooth muscle and alters functional conductance. Curr Neurovasc Res 2010; 7(2): 75-84.
35. 2+ sensitivity. J Gen Physiol 2000; 116(3): 411-432.
36. 2+ spark/STOC coupling and elevated blood pressure. Circ Res 2000; 87(11): E53-E60.