Experimental diabetes mellitus down-regulates large-conductance Ca 2+-activated K+ channels in cerebral artery smooth muscle and alters functional conductance

Current Neurovascular Research

Volumn 7, Issue 2, 2010, Pages 75-84

  Wang, Yan ^a,b   Zhang, Hong Tao ^a   Su, Xing Li ^a   Deng, Xiu Ling ^a   Yuan, Bing Xiang ^b   Zhang, Wei ^a   Wang, Xin Feng ^a   Yang, Yu Bai ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

Author keywords

Cerebral artery; Large conductance Ca2+ activated K+ channel; Type 2 diabetes; Vascular dysfunction; Vascular smooth muscle cells; 1 subunit

Indexed keywords

1 (2 HYDROXY 5 TRIFLUOROMETHYLPHENYL) 5 TRIFLUOROMETHYL 2(3H) BENZIMIDAZOLONE; GLUCOSE; HEMOGLOBIN A1C; INSULIN; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNIT; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL BETA 1 SUBUNIT; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL BETA SUBUNIT; MESSENGER RNA; PAXILLINE; SEROTONIN; STREPTOZOCIN; TETRYLAMMONIUM; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY MUSCLE; ARTICLE; BASILAR ARTERY; BLOOD VESSEL REACTIVITY; CEREBROVASCULAR DISEASE; CHANNEL GATING; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; GLUCOSE BLOOD LEVEL; GLUCOSE INTAKE; HEMOGLOBIN BLOOD LEVEL; HYPERGLYCEMIA; HYPERLIPIDEMIA; HYPERTENSION; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIPID DIET; LOW DRUG DOSE; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATCH CLAMP; POTASSIUM CONDUCTANCE; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE DRUG DOSE; SPRAGUE DAWLEY RAT; STREPTOZOCIN DIABETES; TRANSCRIPTION REGULATION; TRIACYLGLYCEROL BLOOD LEVEL; WESTERN BLOTTING;

EID: 77951725140     PISSN: 15672026     EISSN: None     Source Type: Journal    
DOI: 10.2174/156720210791184925     Document Type: Article

References (33)

1. Tanaka Y, Koike K, Toro L. MaxiK channel roles in blood vessel relaxations induced by endothelium-derived relaxing factors and their molecular mechanisms. J Smooth Muscle Res 2004; 40(4-5): 125-153 (Pubitemid 40204722)
2. 2+ and voltage. Biol Res 2006; 39(3): 385-401.
3. Eichhorn B, Dobrev D. Vascular large conductance calcium-activated potassium channels: functional role and therapeutic potential. Naunyn Schmiedebergs Arch Pharmacol 2007; 376(3): 145-155 (Pubitemid 350029414)
4. Orio P, Rojas P, Ferreira G, Latorre R. New disguises for an old channel MaxiK channel beta-subunits. News Physiol Sci 2002; 17(4): 156-161
5. Dworetzky SI, Boissard CG, Lum-Ragan JT, et al. Phenotypic alteration of a human BK (hSlo) channel by hSlo beta subunit coexpression: changes in blocker sensitivity, activation/relaxation and inactivation kinetics, and protein kinase A modulation. J Neurosci 1996; 16(15): 4543-4550
6. Brenner R, Jegla TJ, Wickenden A, Liu Y, Aldrich RW. Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4. J Biol Chem 2000; 275(9): 6453-6461 (Pubitemid 30129943)
7. Uebele VN, Lagrutta A, Wade T, et al. Cloning and functional expression of two families of beta subunits of the large conductance calcium-activated K+ channel. J Biol Chem 2000; 275(30): 23211-23218 (Pubitemid 30646218)
8. Brenner R, Peréz GJ, Bonev AD, et al. Vasoregulation by the beta1 subunit of the calcium-activated potassium channel. Nature 2000; 407(6808): 870-876
9. 2+ spark/STOC coupling and elevated blood pressure. Circ Res 2000; 87(11): e53-e60.
10. Ho JE, Paultre F, Mosca L. Women's pooling project, Is diabetes mellitus a cardiovascular disease risk equivalent for fatal stroke in women? Data from the women's pooling project. Stroke 2003; 34(12): 2812-2816
11. + channel openers in cerebral arteries from diabetic rats. Circ Res 1997; 81(6): 996-1004.
12. Mayhan WG, Simmons LK, Sharpe GM. Mechanism of impaired responses of cerebral arterioles during diabetes mellitus. Am J Physiol 1991; 260(2 Pt 2): H319-H326.
13. Mayhan WG, Mayhan JF, Sun H, Patel KP. In vivo properties of potassium channels in cerebral blood vessels during diabetes mellitus. Microcirculation 2004; 11(7): 605-613
14. Matsumoto T, Yoshiyama S, Wakabayashi K, Kobayashi T, Kamata K. Effect of chronic insulin on cromakalim-induced relaxation in established streptozotocin-diabetic rat basilar artery. Eur J Pharmacol 2004; 504(1-2): 129-137 (Pubitemid 39410731)
15. Dong L, Zheng YM, Riper DV, et al. Functional and molecular evidence for impairment of calcium-activated potassium channels in type-1 diabetic cerebral artery smooth muscle cells. J Cerebr Blood F Met 2008; 28(2): 377-386 (Pubitemid 351161293)
16. + channels in vascular smooth muscle cells. Eur J Pharmacol 2010; 630 (1-3): 100-106
17. Zhang F, Ye C, Li G, et al. The rat model of type-2 diabetic mellitus and its glycometabolism characters. Exp Anim 2003; 52(5): 401-407 (Pubitemid 41349948)
18. Defronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979; 237(3): E214-E23. (Pubitemid 9249478)
19. Scheen AJ, Lefebvre PJ. Assessment of insulin resistance in vivo: application to the study of type 2 diabetes. Horm Res 1992; 38(1-2): 19-27.
20. 2+ channels are comparable between simulated microgravity rat and SHR. Am J Physiol Heart Circ Physiol 2005; 289(3): H1265-H1276.
21. 2+-activated potassium beta 1 channel subunit in retinal arteriolar smooth muscle. Circ Res 2007; 100(5): 703-711
22. Ganne S, Arora SK, Dotsenko O, McFarlane SI, Whaley-Connell A. Hypertension in people with diabetes and the metabolic syndrome: pathophysiologic insights and therapeutic update. Curr Diab Rep 2007; 7(3): 208-217 (Pubitemid 46951917)
23. Jarajapu YPR, Guberski DL, Grant MB, Knot HJ. Myogenic tone and reactivity of cerebral arteries in Type II diabetic BBZDR/Wor rat. Eur J Pharmacol 2008; 579(1-3): 298-307.
24. + channels in the coronary artery smooth muscle cells of Zucker diabetic fatty rats. Biophys J 2008; 95(11): 5165-5177
25. + channels from arteries of Type 2 diabetic Zucker diabetic fatty rats. Am J Physiol Heart Circ Physiol 2006; 290(4): H1520-H1527.
26. + channel β-subunit from human brain. Proc Natl Acad Sci USA 1996; 93(17): 9200-9205
27. + channels in vascular smooth muscle during hypertension. J Clin Invest 2003; 112(5): 717-724
28. Amberg GC, Santana, LF. Downregulation of the BK channel β1 subunit in genetic hypertension. Circ Res 2003; 93(10): 965-971
29. Nishimaru K, Eghbali M, Lu R, Marijic J, Stefani E, Toto L. Functional and molecular evidence of MaxiK channel β1 subunit decrease with coronary artery ageing in the rat. J Physiol 2004; 559 (Pt 3): 849-862 (Pubitemid 39276173)
30. + channel in Sphincter of oddi cells from rabbits fed with a high cholesterol diet. Acta Biochem Biophys Sin 2006; 38(12): 893-899
31. Creager MA, Lüscher TF, Cosentino F, Beckman JA. Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: Part I. Circulation 2003; 108(12): 1527-1532 (Pubitemid 37176462)
32. + channels by high glucose. Circ Res 2006; 99(6): 607-616
33. Ca currents in cerebral artery smooth muscle cells from streptozotocin-induced diabetic mice. Clin Exp Pharmacol Physiol 2009; 36(10): e57-64.