Structure-activity relationships of carboline and carbazole derivatives as a novel class of ATP-competitive kinesin spindle protein inhibitors

Journal of Medicinal Chemistry

Volumn 54, Issue 13, 2011, Pages 4839-4846

  Takeuchi, Tomoki ^a   Oishi, Shinya ^a   Watanabe, Toshiaki ^a   Ohno, Hiroaki ^a   Sawada, Jun Ichi ^b   Matsuno, Kenji ^b   Asai, Akira ^b   Asada, Naoya ^a   Kitaura, Kazuo ^a   Fujii, Nobutaka ^a  

^a KYOTO UNIVERSITY   (Japan)

^b UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ALPHA CARBOLINE DERIVATIVE; ANTINEOPLASTIC AGENT; BETA CARBOLINE DERIVATIVE; CARBAZOLE DERIVATIVE; CARBOLINE DERIVATIVE; GAMMA CARBOLINE DERIVATIVE; KINESIN; KINESIN INHIBITOR; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; HYDROPHILICITY; MITOSIS; PHENOTYPE; STRUCTURE ACTIVITY RELATION;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; CARBAZOLES; CARBOLINES; HELA CELLS; HUMANS; KINESIN; LACTAMS; MITOSIS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79960153632     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200448n     Document Type: Article

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