Scaffold-mediated nucleation of protein signaling complexes: Elementary principles

Mathematical Biosciences

Volumn 232, Issue 2, 2011, Pages 164-173

  Yang, Jin ^a   Hlavacek, William S ^b,c  

^a INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^b CENTER FOR NONLINEAR STUDIES   (United States)

^c UNIVERSITY OF NEW MEXICO   (United States)

Author keywords

Biological design principles; Combinatorial inhibition; Multivalent binding; Prozone effect; Synthetic biology; Ternary complex

Indexed keywords

BIOLOGICAL DESIGN; COMBINATORIAL INHIBITION; MULTIVALENT BINDING; PROZONE EFFECT; SYNTHETIC BIOLOGY; TERNARY COMPLEX;

BINDING SITES; COMPLEXATION; ENZYMES; FUNCTIONS; LIGANDS; MATHEMATICAL MODELS; NUCLEATION; PHOSPHORYLATION; PROTEINS; SIGNALING; SUBSTRATES;

SCAFFOLDS (BIOLOGY);

CYTOKINE RECEPTOR; IMMUNOGLOBULIN E RECEPTOR; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE SYK; SCAFFOLD PROTEIN;

ENZYME ACTIVITY; INHIBITION; NUCLEATION; NUMERICAL MODEL; PROTEIN;

ARTICLE; BINDING SITE; CATALYSIS; DISSOCIATION CONSTANT; ENZYME KINETICS; ENZYME SPECIFICITY; MATHEMATICAL MODEL; MOLECULAR DOCKING; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEPHOSPHORYLATION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; SIMULATION; SYNTHETIC BIOLOGY;

COMPUTER SIMULATION; HUMANS; LIGANDS; MODELS, BIOLOGICAL; NUCLEAR MATRIX; PROTEIN BINDING; SIGNAL TRANSDUCTION;

EID: 79960137914     PISSN: 00255564     EISSN: 18793134     Source Type: Journal    
DOI: 10.1016/j.mbs.2011.06.003     Document Type: Article

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