Exact analysis of ligand-induced dimerization of monomeric receptors

Analytical Chemistry

Volumn 80, Issue 14, 2008, Pages 5550-5555

  Mack, Eric T ^a   Perez Castillejos, Raquel ^a   Suo, Zhigang ^b   Whitesides, George M ^a  

^a HARVARD UNIVERSITY   (United States)

^b HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIMERIZATION; DISSOCIATION; PROTEINS;

ANALYTICAL EXPRESSIONS; BIFUNCTIONAL LIGANDS; BIVALENT LIGANDS; COOPERATIVITY; DISSOCIATION CONSTANTS; EXACT ANALYSES; INITIAL CONDITIONS; MONOMERIC RECEPTORS;

LIGANDS;

HOMODIMER; LIGAND; MEMBRANE RECEPTOR;

ANALYTIC METHOD; ARTICLE; CONCENTRATION (PARAMETERS); DIMERIZATION; DISSOCIATION CONSTANT; MATHEMATICAL MODEL; PROTEIN ANALYSIS; BIOLOGICAL MODEL; THERMODYNAMICS;

DIMERIZATION; LIGANDS; MODELS, BIOLOGICAL; THERMODYNAMICS;

EID: 49049108184     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac800578w     Document Type: Article

References (18)

1. Klemm, J. D.; Schreiber, S. L.; Crabtree, G. R. Annu. Rev. Immunol. 1998, 16, 569-592.
2. Clackson, T. Controlling Protein-protein Interaction Using Chemical Inducers and Disrupters of Dimerization. In Chemical Biology; Schreiber, S. L., Kapoor, T., Wess, G., Eds.; Wiley-VCH: Weinheim, Germany, 2006; pp 227-246.
3. Alberts, B.; Johnson, A.; Lewis, J.; Raff, M.; Roberts, K.; Walter, P. Molecular Biology of the Cell, 4th ed.; Garland Science: New York, 2002.
4. Mammen, M.; Choi, S.-K.; Whitesides, G. M. Angew. Chem., Int. Ed. 1998, 37, 2754-2794.
5. Choi, S.-K. Synthetic Multivalent Molecules: Concepts and Biomedical Applications; John Wiley & Sons, Inc.: Hoboken, NJ, 2004.
6. Krishnamurthy, V. M.; Estroff, L. A.; Whitesides, G. M. Multivalency in Ligand Design. In Fragment-Based Approaches in Drug Discovery; Jahnke, W., Erlanson, D. A., Eds.; Methods and Principles in Medicinal Chemistry 34; Wiley-VCH: Hoboken, NJ, 2006; pp 11-19.
7. Spencer, D. M.; Wandless, T. J.; Schreiber, S. L.; Crabtree, G. R. Science 1993, 262, 1019-1024.
8. Belshaw, P.; Spencer, D. M.; Crabtree, G. R.; Schreiber, S. L. Chem. Biol. 1996, 3, 731-738.
9. Perelson, A. S.; DeLisi, C. Math. Biosci. 1998, 48, 71-100.
10. Whitty, A.; Borysenko, C. W. Chem. Biol. 1999, 6, R107-R118.
11. Erickson, J.; Kane, P.; Goldstein, B.; Holowka, D.; Baird, B. Mol. Immunol. 1986, 23, 769-781.
12. Carlson, J. C. T.; Kanter, A.; Thuduppathy, G. R.; Cody, V.; Pineda, P. E.; McIvor, R. S.; Wagner, C. R. J. J. Am. Chem. Soc. 2003, 125, 1501-1507.
13. Kopytek, S. J.; Standaert, R. F.; Dyer, J. C. D.; Hu, J. C. Chem. Biol. 2000, 7, 313-321.
14. Braun, P. D.; Wandless, T. J. Biochemistry 2004, 43, 5406-5413.
15. Gargano, J. M.; Ngo, T.; Kim, J. Y.; Acheson, D. W. K.; Lees, W. J. J. J. Am. Chem. Soc. 2001, 123, 12909-12910.
16. Lahiri, J.; Isaacs, L.; Gryzbowski, B.; Carbeck, J. D.; Whitesides, G. M. Langmuir 1999, 15, 7186-7198.
17. Sigurskjold, B. W. Anal. Biochem. 2000, 277, 260-266.
18. Wang, Z.-X. FEBS Lett. 1995, 360, 111-114.