A novel positive feedback loop involving FASN/p-ERK1/2/5-LOX/LTB4/FASN sustains high growth of breast cancer cells

Acta Pharmacologica Sinica

Volumn 32, Issue 7, 2011, Pages 921-929

  Hu, Nan ^a   Li, Yu ^a   Zhao, Yu ^a   Wang, Qi ^a   You, Jia Cong ^a   Zhang, Xiao Dong ^a   Ye, Li Hong ^a  

^a NANKAI UNIVERSITY   (China)

Author keywords

5 lipoxygenase; breast cancer; cell proliferation; extracellular signal regulated kinase; fatty acid synthase; leukotriene B4

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; ARACHIDONATE 5 LIPOXYGENASE; CERULENIN; DEOXYURIDINE; FATTY ACID SYNTHASE; LEUKOTRIENE B4; LUCIFERASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; NORDIHYDROGUAIARETIC ACID; SMALL INTERFERING RNA;

ARTICLE; BREAST CANCER; CANCER CELL; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; ENZYME ASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEEDBACK SYSTEM; HUMAN; HUMAN CELL; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ARACHIDONATE 5-LIPOXYGENASE; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CERULENIN; FATTY ACID SYNTHESIS INHIBITORS; FATTY ACID SYNTHETASE COMPLEX; FEEDBACK, PHYSIOLOGICAL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LEUKOTRIENE B4; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PROMOTER REGIONS, GENETIC; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 79960037452     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2011.40     Document Type: Article

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