Pathway crosstalk between Ras/RAF and PI3K in promotion of M-CSF-induced MEK/ERK-mediated osteoclast survival

Journal of Cellular Biochemistry

Volumn 104, Issue 4, 2008, Pages 1439-1451

  Bradley, Elizabeth W ^a   Ruan, Ming M ^b   Vrable, Anne ^b   Oursler, Merry Jo ^a,b  

^a MAYO GRADUATE SCHOOL   (United States)

^b MAYO CLINIC   (United States)

Author keywords

Apoptosis; M CSF; MEK; Osteoclast; PI3K; Ras

Indexed keywords

COLONY STIMULATING FACTOR 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; RAF PROTEIN; RAS PROTEIN;

ANIMAL CELL; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME INHIBITION; MOUSE; NONHUMAN; OSTEOCLAST; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL SURVIVAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; MACROPHAGE COLONY-STIMULATING FACTOR; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; OSTEOCLASTS; RAF KINASES; RAS PROTEINS; RECEPTOR CROSS-TALK; SIGNAL TRANSDUCTION;

EID: 46949083308     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.21719     Document Type: Article

References (37)

1. Akiyama T, Miyazaki T, Bouillet P, Nakamura K, Strasser A, Tanaka S. 2005. In vitro and in vivo assays for osteoclast apoptosis. Biol Proced Online 7:48-59.
2. Alessi DR, Saito Y, Campbell DG, Cohen P, Sithanandam G, Rapp U, Ashworth A, Marshall CJ, Cowley S. 1994. Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1. EMBO J 13:1610-1619.
3. Arai F, Miyamoto T, Ohneda O, Inada T, Sudo T, Brasel K, Miyata T, Anderson DM, Suda T. 1999. Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor kappaB (RANK) receptors. J Exp Med 190:1741-1754.
4. Buscher D, Hipskind RA, Krautwald S, Reimann T, Baccarini M. 1995. Ras-dependent and -independent pathways target the mitogen-activated protein kinase network in macrophages. Mol Cell Biol 15:466-475.
5. Carboni JM, Yan N, Cox AD, Bustelo X, Graham SM, Lynch MJ, Weinmann R, Seizinger BR, Der CJ, Barbacid M, et al. 1995. Farnesyltransferase inhibitors are inhibitors of Ras but not R-Ras2/TC21, transformation. Oncogene 10:1905-1913.
6. Chong H, Lee J, Guan KL. 2001. Positive and negative regulation of Raf kinase activity and function by phosphorylation. EMBO J 20:3716-3727.
7. Cox AD, Hisaka MM, Buss JE, Der CJ. 1992. Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein. Mol Cell Biol 12:2606-2615.
8. Coxon FP, Helfrich MH, Van't Hof R, Sebti S, Ralston SH, Hamilton A, Rogers MJ. 2000. Protein geranylgeranylation is required for osteoclast formation, function, and survival: Inhibition by bisphosphonates and GGTI-298. J Bone Miner Res 15:1467-1476.
9. Dougherty MK, Muller J, Ritt DA, Zhou M, Zhou XZ, Copeland TD, Conrads TP, Veenstra TD, Lu KP, Morrison DK. 2005. Regulation of Raf-1 by direct feedback phosphorylation. Mol Cell 17:215-224.
10. Edme N, Downward J, Thiery JP, Boyer B. 2002. Ras induces NBT-II epithelial cell scattering through the coordinate activities of Rac and MAPK pathways. J Cell Sci 115:2591-2601.
11. Fuller K, Owens JM, Jagger CJ, Wilson A, Moss R, Chambers TJ. 1993. Macrophage colony-stimulating factor stimulates survival and chemotactic behavior in isolated osteoclasts. J Exp Med 178:1733-1744.
12. Gingery A, Bradley E, Shaw A, Oursler MJ. 2003. Phosphatidylinositol 3-kinase coordinately activates the MEK/ERK and AKT/NFkappaB pathways to maintain osteoclast survival. J Cell Biochem 89:165-179.
13. Glantschnig H, Fisher JE, Wesolowski G, Rodan GA, Reszka AA. 2003. M-CSF, TNFalpha and RANK ligand promote osteoclast survival by signaling through mTOR/S6 kinase. Cell Death Differ 10:1165-1177.
14. Hume DA, Yue X, Ross IL, Favot P, Lichanska A, Ostrowski MC. 1997. Regulation of CSF-1 receptor expression. Mol Reprod Dev 46:46-52; discussion 52-3.
15. Jaworowski A, Christy E, Yusoff P, Byrne R, Hamilton JA. 1996. Differences in the kinetics of activation of protein kinases and extracellular signal-related protein kinase 1 in colony-stimulating factor 1-stimulated and lipopolysaccharide-stimulated macrophages. Biochem J 320(Pt 3):1011-1016.
16. Kelley TW, Graham MM, Doseff AI, Pomerantz RW, Lau SM, Ostrowski MC, Franke TF, Marsh CB. 1999. Macrophage colony-stimulating factor promotes cell survival through Akt/protein kinase B. J Biol Chem 274:26393-26398.
17. Kolch W. 2000. Meaningful relationships: The regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. Biochem J 351(Pt 2):289-305.
18. Lee AW, States DJ. 2000. Both src-dependent and - independent mechanisms mediate phosphatidylinositol 3-kinase regulation of colony-stimulating factor 1-activated mitogen-activated protein kinases in myeloid progenitors. Mol Cell Biol 20:6779-6798.
19. Lee AW, States DJ. 2006. Colony-stimulating factor-1 requires PI3-kinase-mediated metabolism for proliferation and survival in myeloid cells. Cell Death Differ 13:1900-1914.
20. Luckman SP, Hughes DE, Coxon FP, Graham R, Russell G, Rogers MJ. 1998. Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. J Bone Miner Res 13:581-589.
21. Marais R, Light Y, Paterson HF, Mason CS, Marshall CJ. 1997. Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases. J Biol Chem 272:4378-4383.
22. Miyazaki T, Katagiri H, Kanegae Y, Takayanagi H, Sawada Y, Yamamoto A, Pando MP, Asano T, Verma IM, Oda H, Nakamura K, Tanaka S. 2000. Reciprocal role of ERK and NF-kappaB pathways in survival and activation of osteoclasts. J Cell Biol 148:333-342.
23. Peyssonnaux C, Eychene A. 2001. The Raf/MEK/ERK pathway: New concepts of activation. Biol Cell 93:53-62.
24. Ponzetto C, Bardelli A, Maina F, Longati P, Panayotou G, Dhand R, Waterfield MD, Comoglio PM. 1993. A novel recognition motif for phosphatidylinositol 3-kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptor. Mol Cell Biol 13:4600-4608.
25. Rodan GA, Martin TJ. 2000. Therapeutic approaches to bone diseases. Science 289:1508-1514.
26. Sato S, Fujita N, Tsuruo T. 2004. Involvement of 3-phosphoinositide- dependent protein kinase-1 in the MEK/MAPK signal transduction pathway. J Biol Chem 279:33759-33767.
27. Sells Galvin RJ, Gatlin CL, Horn JW, Fuson TR. 1999. TGF-beta enhances osteoclast differentiation in hematopoietic cell cultures stimulated with RANKL and M-CSF. Biochem Biophys Res Commun 265:233-239.
28. Stoyanov B, Volinia S, Hanck T, Rubio I, Loubtchenkov M, Malek D, Stoyanova S, Vanhaesebroeck B, Dhand R, Nurnberg B, et al. 1995. Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase. Science 269:690-693.
29. Sun H, King AJ, Diaz HB, Marshall MS. 2000. Regulation of the protein kinase Raf-1 by oncogenic Ras through phosphatidylinositol 3-kinase, Cdc42/Rac and Pak. Curr Biol 10:281-284.
30. Takahashi N, Akatsu T, Udagawa N, Sasaki T, Yamaguchi A, Moseley JM, Martin TJ, Suda T. 1988. Osteoblastic cells are involved in osteoclast formation. Endocrinology 123:2600-2602.
31. Udagawa N, Takahashi N, Akatsu T, Tanaka H, Sasaki T, Nishihara T, Koga T, Martin TJ, Suda T. 1990. Origin of osteoclasts: Mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells. Proc Natl Acad Sci USA 87:7260-7264.
32. Wennstrom S, Downward J. 1999. Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor. Mol Cell Biol 19:4279-4288.
33. White MA, Nicolette C, Minden A, Polverino A, Van Aelst L, Karin M, Wigler MH. 1995. Multiple Ras functions can contribute to mammalian cell transformation. Cell 80:533-541.
34. Yang FC, Chen S, Robling AG, Yu X, Nebesio TD, Yan J, Morgan T, Li X, Yuan J, Hock J, Ingram DA, Clapp DW. 2006. Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions. J Clin Invest 116: 2880-2891.
35. Zang M, Waelde CA, Xiang X, Rana A, Wen R, Luo Z. 2001. Microtubule integrity regulates Pak leading to Ras-independent activation of Raf-1. insights into mechanisms of Raf-1 activation. J Biol Chem 276:25157-25165.
36. Zang M, Hayne C, Luo Z. 2002. Interaction between active Pak1 and Raf-1 is necessary for phosphorylation and activation of Raf-1. J Biol Chem 277:4395-4405.
37. Zimmermann S, Moelling K. 1999. Phosphorylation and regulation of Raf by Akt (protein kinase B). Science 286:1741-1744.