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Volumn 5, Issue 2, 2011, Pages 86-91

MicroRNAs patents: The road from bench to bedsides for cancer treatment

Author keywords

Gene expression; MicroRNA; MiR drugs; MiRNome; Patents; Treatment

Indexed keywords

BIOLOGICAL MARKER; LET 7; MICRORNA; MICRORNA 106A 92; MICRORNA 122 INHIBITOR; MICRORNA 126; MICRORNA 17 92; MICRORNA 205; MICRORNA 21; MICRORNA 34A; PROTEIN INHIBITOR; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

EID: 79960029337     PISSN: 18722156     EISSN: None     Source Type: Journal    
DOI: 10.2174/187221511796392079     Document Type: Review
Times cited : (6)

References (65)
  • 2
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116(2): 281-97.
    • (2004) Cell , vol.116 , Issue.2 , pp. 281-297
    • Bartel, D.P.1
  • 3
    • 0027751663 scopus 로고
    • The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993; 75(5): 843-54.
    • (1993) Cell , vol.75 , Issue.5 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 4
    • 0035955374 scopus 로고    scopus 로고
    • Identification of novel genes coding for small expressed RNAs
    • Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T. Identification of novel genes coding for small expressed RNAs. Science 2001; 294(5543): 853-8.
    • (2001) Science , vol.294 , Issue.5543 , pp. 853-858
    • Lagos-Quintana, M.1    Rauhut, R.2    Lendeckel, W.3    Tuschl, T.4
  • 5
    • 0035955361 scopus 로고    scopus 로고
    • An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans
    • Lau NC, Lim LP, Weinstein EG, Bartel DP. An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science 2001; 294(5543): 858-62.
    • (2001) Science , vol.294 , Issue.5543 , pp. 858-862
    • Lau, N.C.1    Lim, L.P.2    Weinstein, E.G.3    Bartel, D.P.4
  • 6
    • 0035955366 scopus 로고    scopus 로고
    • An extensive class of small RNAs in Caenorhabditis elegans
    • Lee RC, Ambros V. An extensive class of small RNAs in Caenorhabditis elegans. Science 2001; 294(5543): 862-4.
    • (2001) Science , vol.294 , Issue.5543 , pp. 862-864
    • Lee, R.C.1    Ambros, V.2
  • 7
    • 0034708122 scopus 로고    scopus 로고
    • The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
    • Reinhart BJ, Slack FJ, Basson M, et al. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature 2000; 403(6772): 901-6.
    • (2000) Nature , vol.403 , Issue.6772 , pp. 901-906
    • Reinhart, B.J.1    Slack, F.J.2    Basson, M.3
  • 8
    • 18344369543 scopus 로고    scopus 로고
    • MicroRNA biogenesis: Coordinated cropping and dicing
    • Kim VN. MicroRNA biogenesis: coordinated cropping and dicing. Nat Rev Mol Cell Biol 2005; 6(5): 376-85.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , Issue.5 , pp. 376-385
    • Kim, V.N.1
  • 9
    • 77957361864 scopus 로고    scopus 로고
    • Targeting microRNAs in cancer: Rationale, strategies and challenges
    • Garzon R, Marcucci G, Croce CM. Targeting microRNAs in cancer: rationale, strategies and challenges. Nat Rev Drug Discov 2010; 9(10): 775-89.
    • (2010) Nat Rev Drug Discov , vol.9 , Issue.10 , pp. 775-789
    • Garzon, R.1    Marcucci, G.2    Croce, C.M.3
  • 10
    • 77954943288 scopus 로고    scopus 로고
    • Attenuation of microRNA-1 derepresses the cytoskeleton regulatory protein twinfilin-1 to provoke cardiac hypertrophy
    • Li Q, Song XW, Zou J, et al. Attenuation of microRNA-1 derepresses the cytoskeleton regulatory protein twinfilin-1 to provoke cardiac hypertrophy. J Cell Sci 2010; 123(Pt 14): 2444-52.
    • (2010) J Cell Sci , vol.123 , Issue.PART 14 , pp. 2444-2452
    • Li, Q.1    Song, X.W.2    Zou, J.3
  • 11
    • 79952994992 scopus 로고    scopus 로고
    • miR-124a as a key regulator of proliferation and MCP-1 secretion in synoviocytes from patients with rheumatoid arthritis
    • Kawano S, Nakamachi Y. miR-124a as a key regulator of proliferation and MCP-1 secretion in synoviocytes from patients with rheumatoid arthritis. Ann Rheum Dis 2011; 70 Suppl 1: i88-91.
    • (2011) Ann Rheum Dis , vol.70 , Issue.SUPPL 1
    • Kawano, S.1    Nakamachi, Y.2
  • 12
    • 33750370444 scopus 로고    scopus 로고
    • MicroRNA signatures in human cancers
    • Calin GA, Croce CM. MicroRNA signatures in human cancers. Nat Rev Cancer 2006; 6(11): 857-66.
    • (2006) Nat Rev Cancer , vol.6 , Issue.11 , pp. 857-866
    • Calin, G.A.1    Croce, C.M.2
  • 13
    • 79959985946 scopus 로고    scopus 로고
    • MicroRNA and cancer: Current status and prospective
    • Wu W, Sun M, Zou GM, Chen J. MicroRNA and cancer: Current status and prospective. Int J Cancer 2006.
    • (2006) Int J Cancer
    • Wu, W.1    Sun, M.2    Zou, G.M.3    Chen, J.4
  • 14
    • 18744396337 scopus 로고    scopus 로고
    • Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
    • Calin GA, Dumitru CD, Shimizu M, et al. Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA. 2002; 99(24): 15524-9.
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.24 , pp. 15524-15529
    • Calin, G.A.1    Dumitru, C.D.2    Shimizu, M.3
  • 15
    • 2542626605 scopus 로고    scopus 로고
    • Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival
    • Takamizawa J, Konishi H, Yanagisawa K, et al. Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Res 2004; 64(11): 3753-6.
    • (2004) Cancer Res , vol.64 , Issue.11 , pp. 3753-3756
    • Takamizawa, J.1    Konishi, H.2    Yanagisawa, K.3
  • 16
    • 33644819964 scopus 로고    scopus 로고
    • Unique microRNA molecular profiles in lung cancer diagnosis and prognosis
    • Yanaihara N, Caplen N, Bowman E, et al. Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell 2006; 9(3): 189-98.
    • (2006) Cancer Cell , vol.9 , Issue.3 , pp. 189-198
    • Yanaihara, N.1    Caplen, N.2    Bowman, E.3
  • 17
    • 33144490646 scopus 로고    scopus 로고
    • A microRNA expression signature of human solid tumors defines cancer gene targets
    • Volinia S, Calin GA, Liu CG, et al. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA 2006; 103(7): 2257-61.
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.7 , pp. 2257-2261
    • Volinia, S.1    Calin, G.A.2    Liu, C.G.3
  • 18
    • 20444460289 scopus 로고    scopus 로고
    • MicroRNA expression profiles classify human cancers
    • Lu J, Getz G, Miska EA, et al. MicroRNA expression profiles classify human cancers. Nature 2005; 435(7043): 834-8.
    • (2005) Nature , vol.435 , Issue.7043 , pp. 834-838
    • Lu, J.1    Getz, G.2    Miska, E.A.3
  • 19
    • 42449098100 scopus 로고    scopus 로고
    • Normalization of microRNA expression levels in quantitative RT-PCR assays: Identification of suitable reference RNA targets in normal and cancerous human solid tissues
    • Peltier HJ, Latham GJ. Normalization of microRNA expression levels in quantitative RT-PCR assays: identification of suitable reference RNA targets in normal and cancerous human solid tissues. RNA 2008; 14(5): 844-52.
    • (2008) RNA , vol.14 , Issue.5 , pp. 844-852
    • Peltier, H.J.1    Latham, G.J.2
  • 20
    • 77951841445 scopus 로고    scopus 로고
    • Reprogramming of miRNA networks in cancer and leukemia
    • Volinia S, Galasso M, Costinean S, et al. Reprogramming of miRNA networks in cancer and leukemia. Genome Res 2010; 20(5): 589-99.
    • (2010) Genome Res , vol.20 , Issue.5 , pp. 589-599
    • Volinia, S.1    Galasso, M.2    Costinean, S.3
  • 21
    • 77952742610 scopus 로고    scopus 로고
    • Network modeling identifies molecular functions targeted by miR-204 to suppress head and neck tumor metastasis
    • Lee Y, Yang X, Huang Y, et al. Network modeling identifies molecular functions targeted by miR-204 to suppress head and neck tumor metastasis. PLoS Comput Biol 2010; 6(4): e1000730.
    • (2010) PLoS Comput Biol , vol.6 , Issue.4
    • Lee, Y.1    Yang, X.2    Huang, Y.3
  • 27
    • 48749122914 scopus 로고    scopus 로고
    • Circulating microRNAs as stable blood-based markers for cancer detection
    • Mitchell PS, Parkin RK, Kroh EM, et al. Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA 2008; 105(30): 10513-8.
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.30 , pp. 10513-10518
    • Mitchell, P.S.1    Parkin, R.K.2    Kroh, E.M.3
  • 28
    • 78149484489 scopus 로고    scopus 로고
    • The microRNA spectrum in 12 body fluids
    • Weber JA, Baxter DH, Zhang S, et al. The microRNA spectrum in 12 body fluids. Clin Chem 2010; 56(11): 1733-41.
    • (2010) Clin Chem , vol.56 , Issue.11 , pp. 1733-1741
    • Weber, J.A.1    Baxter, D.H.2    Zhang, S.3
  • 29
    • 78449296222 scopus 로고    scopus 로고
    • MicroRNA expression and clinical outcomes in patients treated with adjuvant chemotherapy after complete resection of non-small cell lung carcinoma
    • Voortman J, Goto A, Mendiboure J, et al. MicroRNA expression and clinical outcomes in patients treated with adjuvant chemotherapy after complete resection of non-small cell lung carcinoma. Cancer Res 2010; 70(21): 8288-98.
    • (2010) Cancer Res , vol.70 , Issue.21 , pp. 8288-8298
    • Voortman, J.1    Goto, A.2    Mendiboure, J.3
  • 30
    • 33646181367 scopus 로고    scopus 로고
    • Anti-miRNA oligonucleotides (AMOs): Ammunition to target miRNAs implicated in human disease?
    • Weiler J, Hunziker J, Hall J. Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease? Gene Ther 2005.
    • (2005) Gene Ther
    • Weiler, J.1    Hunziker, J.2    Hall, J.3
  • 31
    • 34548316982 scopus 로고    scopus 로고
    • MicroRNA sponges: Competitive inhibitors of small RNAs in mammalian cells
    • Ebert MS, Neilson JR, Sharp PA. MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells. Nat Methods 2007; 4(9): 721-6.
    • (2007) Nat Methods , vol.4 , Issue.9 , pp. 721-726
    • Ebert, M.S.1    Neilson, J.R.2    Sharp, P.A.3
  • 32
    • 34347381752 scopus 로고    scopus 로고
    • Novel approaches for gene-specific interference via manipulating actions of microRNAs: Examination on the pacemaker channel genes HCN2 and HCN4
    • Xiao J, Yang B, Lin H, Lu Y, Luo X, Wang Z. Novel approaches for gene-specific interference via manipulating actions of microRNAs: examination on the pacemaker channel genes HCN2 and HCN4. J Cell Physiol 2007; 212(2): 285-92.
    • (2007) J Cell Physiol , vol.212 , Issue.2 , pp. 285-292
    • Xiao, J.1    Yang, B.2    Lin, H.3    Lu, Y.4    Luo, X.5    Wang, Z.6
  • 33
    • 77951604310 scopus 로고    scopus 로고
    • Regression of murine lung tumors by the let-7 microRNA
    • Trang P, Medina PP, Wiggins JF, et al. Regression of murine lung tumors by the let-7 microRNA. Oncogene 2009.
    • (2009) Oncogene
    • Trang, P.1    Medina, P.P.2    Wiggins, J.F.3
  • 35
    • 79957900919 scopus 로고    scopus 로고
    • Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice
    • Trang P, Wiggins JF, Daige CL, et al. Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice. Mol Ther 2011.
    • (2011) Mol Ther
    • Trang, P.1    Wiggins, J.F.2    Daige, C.L.3
  • 37
    • 54249136806 scopus 로고    scopus 로고
    • MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells
    • Papagiannakopoulos T, Shapiro A, Kosik KS. MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells. Cancer Res 2008; 68(19): 8164-72.
    • (2008) Cancer Res , vol.68 , Issue.19 , pp. 8164-8172
    • Papagiannakopoulos, T.1    Shapiro, A.2    Kosik, K.S.3
  • 38
    • 41749113108 scopus 로고    scopus 로고
    • MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer
    • Asangani IA, Rasheed SA, Nikolova DA, et al. MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 2008; 27(15): 2128-36.
    • (2008) Oncogene , vol.27 , Issue.15 , pp. 2128-2136
    • Asangani, I.A.1    Rasheed, S.A.2    Nikolova, D.A.3
  • 39
    • 34547524771 scopus 로고    scopus 로고
    • MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
    • Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST, Patel T. MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 2007; 133(2): 647-58.
    • (2007) Gastroenterology , vol.133 , Issue.2 , pp. 647-658
    • Meng, F.1    Henson, R.2    Wehbe-Janek, H.3    Ghoshal, K.4    Jacob, S.T.5    Patel, T.6
  • 40
    • 50249173450 scopus 로고    scopus 로고
    • MiR-21 promotes glioma invasion by targeting MMP regulators
    • Gabriely G, Wurdinger T, Kesari S, et al. MiR-21 promotes glioma invasion by targeting MMP regulators. Mol Cell Biol 2008; 28(17): 5369-80.
    • (2008) Mol Cell Biol , vol.28 , Issue.17 , pp. 5369-5380
    • Gabriely, G.1    Wurdinger, T.2    Kesari, S.3
  • 41
    • 40249092910 scopus 로고    scopus 로고
    • MicroRNA-21 targets tumor suppressor genes in invasion and metastasis
    • Zhu S, Wu H, Wu F, Nie D, Sheng S, Mo YY. MicroRNA-21 targets tumor suppressor genes in invasion and metastasis. Cell Res 2008; 18(3): 350-9.
    • (2008) Cell Res , vol.18 , Issue.3 , pp. 350-359
    • Zhu, S.1    Wu, H.2    Wu, F.3    Nie, D.4    Sheng, S.5    Mo, Y.Y.6
  • 42
    • 79959843370 scopus 로고    scopus 로고
    • MicroRNA-21 targets tumor suppressor genes ANP32A and SMARCA4
    • Schramedei K, Morbt N, Pfeifer G, et al. MicroRNA-21 targets tumor suppressor genes ANP32A and SMARCA4. Oncogene 2011.
    • (2011) Oncogene
    • Schramedei, K.1    Morbt, N.2    Pfeifer, G.3
  • 43
    • 57749168828 scopus 로고    scopus 로고
    • MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
    • Thum T, Gross C, Fiedler J, et al. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature 2008; 456(7224): 980-4.
    • (2008) Nature , vol.456 , Issue.7224 , pp. 980-984
    • Thum, T.1    Gross, C.2    Fiedler, J.3
  • 45
    • 77952584924 scopus 로고    scopus 로고
    • Targeting microRNAs with small molecules: From dream to reality
    • Zhang S, Chen L, Jung EJ, Calin GA. Targeting microRNAs with small molecules: from dream to reality. Clin Pharmacol Ther 2010; 87(6): 754-8.
    • (2010) Clin Pharmacol Ther , vol.87 , Issue.6 , pp. 754-758
    • Zhang, S.1    Chen, L.2    Jung, E.J.3    Calin, G.A.4
  • 46
    • 28444469246 scopus 로고    scopus 로고
    • Silencing of microRNAs in vivo with 'antagomirs'
    • Krutzfeldt J, Rajewsky N, Braich R, et al. Silencing of microRNAs in vivo with 'antagomirs'. Nature 2005; 438(7068): 685-9.
    • (2005) Nature , vol.438 , Issue.7068 , pp. 685-689
    • Krutzfeldt, J.1    Rajewsky, N.2    Braich, R.3
  • 47
    • 33645075443 scopus 로고    scopus 로고
    • miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting
    • Esau C, Davis S, Murray SF, et al. miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. Cell Metab 2006; 3(2): 87-98.
    • (2006) Cell Metab , vol.3 , Issue.2 , pp. 87-98
    • Esau, C.1    Davis, S.2    Murray, S.F.3
  • 48
    • 74249112787 scopus 로고    scopus 로고
    • Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection
    • Lanford RE, Hildebrandt-Eriksen ES, Petri A, et al. Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection. Science 2010; 327(5962): 198-201.
    • (2010) Science , vol.327 , Issue.5962 , pp. 198-201
    • Lanford, R.E.1    Hildebrandt-Eriksen, E.S.2    Petri, A.3
  • 49
    • 54049084380 scopus 로고    scopus 로고
    • A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition
    • Bracken CP, Gregory PA, Kolesnikoff N, et al. A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. Cancer Res 2008; 68(19): 7846-54.
    • (2008) Cancer Res , vol.68 , Issue.19 , pp. 7846-7854
    • Bracken, C.P.1    Gregory, P.A.2    Kolesnikoff, N.3
  • 50
    • 33751520430 scopus 로고    scopus 로고
    • Natural selection on human microRNA binding sites inferred from SNP data
    • Chen K, Rajewsky N. Natural selection on human microRNA binding sites inferred from SNP data. Nat Genet 2006; 38(12): 1452-6.
    • (2006) Nat Genet , vol.38 , Issue.12 , pp. 1452-1456
    • Chen, K.1    Rajewsky, N.2
  • 51
    • 60149095444 scopus 로고    scopus 로고
    • Most mammalian mRNAs are conserved targets of microRNAs
    • Friedman RC, Farh KK, Burge CB, Bartel DP. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 2009; 19(1): 92-105.
    • (2009) Genome Res , vol.19 , Issue.1 , pp. 92-105
    • Friedman, R.C.1    Farh, K.K.2    Burge, C.B.3    Bartel, D.P.4
  • 52
    • 77955475953 scopus 로고    scopus 로고
    • Expanding the microRNA targeting code: Functional sites with centered pairing
    • Shin C, Nam JW, Farh KK, Chiang HR, Shkumatava A, Bartel DP. Expanding the microRNA targeting code: functional sites with centered pairing. Mol Cell 2010; 38(6): 789-802.
    • (2010) Mol Cell , vol.38 , Issue.6 , pp. 789-802
    • Shin, C.1    Nam, J.W.2    Farh, K.K.3    Chiang, H.R.4    Shkumatava, A.5    Bartel, D.P.6
  • 53
    • 36749026906 scopus 로고    scopus 로고
    • Switching from repression to activation: MicroRNAs can up-regulate translation
    • Vasudevan S, Tong Y, Steitz JA. Switching from repression to activation: microRNAs can up-regulate translation. Science 2007; 318(5858): 1931-4.
    • (2007) Science , vol.318 , Issue.5858 , pp. 1931-1934
    • Vasudevan, S.1    Tong, Y.2    Steitz, J.A.3
  • 54
    • 18844380174 scopus 로고    scopus 로고
    • Polymorphisms in human pre-miRNAs
    • Iwai N, Naraba H. Polymorphisms in human pre-miRNAs. Biochem Biophys Res Commun 2005; 331(4): 1439-44.
    • (2005) Biochem Biophys Res Commun , vol.331 , Issue.4 , pp. 1439-1444
    • Iwai, N.1    Naraba, H.2
  • 55
    • 40949137791 scopus 로고    scopus 로고
    • Polymorphisms within micro-RNA-binding sites and risk of sporadic colorectal cancer
    • Landi D, Gemignani F, Naccarati A, et al. Polymorphisms within micro-RNA-binding sites and risk of sporadic colorectal cancer. Carcinogenesis 2008; 29(3): 579-84.
    • (2008) Carcinogenesis , vol.29 , Issue.3 , pp. 579-584
    • Landi, D.1    Gemignani, F.2    Naccarati, A.3
  • 56
    • 54949154476 scopus 로고    scopus 로고
    • MiRNA-directed regulation of VEGF and other angiogenic factors under hypoxia
    • Hua Z, Lv Q, Ye W, et al. MiRNA-directed regulation of VEGF and other angiogenic factors under hypoxia. PLoS One 2006; 1: e116.
    • (2006) PLoS One , vol.1
    • Hua, Z.1    Lv, Q.2    Ye, W.3
  • 57
    • 33751548288 scopus 로고    scopus 로고
    • Diversity of microRNAs in human and chimpanzee brain
    • Berezikov E, Thuemmler F, van Laake LW, et al. Diversity of microRNAs in human and chimpanzee brain. Nat Genet 2006; 38(12): 1375-7.
    • (2006) Nat Genet , vol.38 , Issue.12 , pp. 1375-1377
    • Berezikov, E.1    Thuemmler, F.2    van Laake, L.W.3
  • 58
    • 79951568817 scopus 로고    scopus 로고
    • Discovery of novel human breast cancer MicroRNAs from deep sequencing data by analysis of Pri-MicroRNA secondary structures
    • Ryu S, Joshi N, McDonnell K, et al. Discovery of novel human breast cancer MicroRNAs from deep sequencing data by analysis of Pri-MicroRNA secondary structures. PLoS One 2011; 6(2): e16403.
    • (2011) PLoS One , vol.6 , Issue.2
    • Ryu, S.1    Joshi, N.2    McDonnell, K.3


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