Coupling Met to specific pathways results in distinct developmental outcomes

Molecular Cell

Volumn 7, Issue 6, 2001, Pages 1293-1306

  Maina, Flavio ^a   Panté, Guido ^a,b   Helmbacher, Françoise ^a   Andres, Rosa ^c   Porthin, Annika ^a   Davies, Alun M ^c   Ponzetto, Carola ^b   Klein, Rüdiger ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^b UNIVERSITY OF TURIN   (Italy)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; MUTANT PROTEIN; MUTANT PROTEIN MET 2G; MUTANT PROTEIN MET 2P; MUTANT PROTEIN MET 2S; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN; PROTEIN GAB1; PROTEIN TYROSINE KINASE; SCATTER FACTOR RECEPTOR; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; CELL FUNCTION; CELL MATURATION; CELL PROLIFERATION; CONGENITAL MALFORMATION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; HUMAN; IN VIVO STUDY; LIVER CELL; MOUSE; MOUSE MUTANT; MUSCLE DEVELOPMENT; MYOBLAST; NERVE GROWTH; NEUROPATHY; NONHUMAN; PHENOTYPE; PLACENTA DEVELOPMENT; PROTEIN BINDING; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RECEPTOR BINDING; RESPIRATORY FAILURE; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0034969431     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(01)00261-1     Document Type: Article

References (22)

1. Concomitant activation of pathways downstream of Grb2 and PI 3-kinase is required for MET-mediated metastasis
2. Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase
3. The branchial arches and HGF are growth-promoting and chemoattractant for cranial motor axons
4. Nerve growth factor activation of the extracellular signal-regulated kinase pathway is modulated by Ca(2+) and calmodulin
5. Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes
6. Efficient cellular transformation by the Met oncoprotein requires a functional Grb2 binding site and correlates with phosphorylation of the Grb2-associated proteins, Cbl and Gab1
7. Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor
8. Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation
9. Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development
10. Met receptor signaling is required for sensory nerve development and HGF promotes axonal growth and survival of sensory neurons
11. Multiple roles for hepatocyte growth factor in sympathetic neuron development
12. Hepatocyte growth factor - A versatile signal for developing neurons
13. Protein-protein interactions define specificity in signal transduction
14. Signaling networks - Do all roads lead to the same genes?
15. A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family
16. Essential role of Gab1 for signaling by the c-Met receptor in vivo
17. Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses
18. Cell signaling by receptor tyrosine kinases
19. A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells
20. Receptor Tyrosine Kinases: Specific outcomes from general signals
21. SH2 domains recognize specific phophopeptide sequences
22. A transgenic neuroanatomical marker identifies cranial neural crest deficiencies associated with the Pax3 mutant Splotch