The use of in situ near infrared spectroscopy to provide mechanistic insights into gel layer development in HPMC hydrophilic matrices

European Journal of Pharmaceutical Sciences

Volumn 43, Issue 5, 2011, Pages 400-408

  Avalle, Paolo ^a   Pygall, Samuel R ^a   Gower, Nick ^a   Midwinter, Anna ^a  

^a MSD   (United Kingdom)

Author keywords

Chemical imaging; Drug release; HPMC; Hydrophilic matrix; NIR

Indexed keywords

FAST FLO 316; HYDROXYPROPYLMETHYLCELLULOSE; LACTOSE; MAGNESIUM STEARATE; METHYLCELLULOSE; MICROCRYSTALLINE CELLULOSE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED RELEASE FORMULATION; DRUG SOLUBILITY; GEL; HYDROPHILICITY; NEAR INFRARED SPECTROSCOPY; PRIORITY JOURNAL; VALIDATION PROCESS;

METHYLCELLULOSE; SOLUBILITY; SPECTROSCOPY, NEAR-INFRARED; TABLETS; WATER;

EID: 79959956931     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2011.05.013     Document Type: Article

References (27)

1. D.A. Alderman A review of cellulose ethers in hydrophilic matrices for oral controlled-release dosage forms Int. J. Pharm. Technol. Prod. Manuf. 5 1984 1 9 (Pubitemid 15105124)
2. G.S. Bajwa, K. Hoebler, C. Sammon, P. Timmins, and C.D. Melia Microstructural imaging of early gel layer formation in HPMC matrices J. Pharm. Sci. 95 2006 2145 2157 (Pubitemid 44568526)
3. R. Bettini, P.L. Catellani, P. Santi, G. Massimo, N.A. Peppas, and P. Colombo Translocation of drug particles in HPMC matrix gel layer: effect of drug solubility and influence on release rate J. Control. Release 70 2001 383 391 (Pubitemid 32155461)
4. Christensen, G.L., Dale, L.B., 1962. Sustained Release Tablet, United States. US Patent 3065,143. Richardson-Merrell Inc., Delaware.
5. P. Colombo, R. Bettini, and N.A. Peppas Observation of swelling process and diffusion front position during swelling in hydroxypropyl methyl cellulose (HPMC) matrices containing a soluble drug J. Control. Release 61 1999 83 91 (Pubitemid 29406082)
6. P.M. Fechner, S. Wartewig, A. Kiesow, A. Heilmann, P. Kleinebudde, and R.H.H. Neubert Interaction of water with different cellulose ethers: a Raman spectroscopy and environmental scanning electron microscopy study J. Pharm. Pharmacol. 57 6 2005 689 698 (Pubitemid 40694876)
7. C. Ferrero, D. Massuelle, D. Jeannerat, and E. Doelker Towards elucidation of the drug release mechanism from compressed hydrophilic matrices made of cellulose ethers: I. Pulse-field-gradient spin-echo NMR study of sodium salicylate diffusivity in swollen hydrogels with respect to polymer matrix physical structure J. Control. Release 128 2008 71 79
8. J.L. Ford, K. Mitchell, P. Rowe, D.J. Armstrong, P.N.C. Elliott, C. Rostron, and J.E. Hogan Mathematical modelling of drug release from hydroxypropylmethylcellulose matrices: effect of temperature Int. J. Pharm. 71 1991 95 104
9. P. Gao, and R.H. Meury Swelling of hydroxypropyl methylcellulose matrix tablets: 1. Characterization of swelling using a novel optical imaging method J. Pharm. Sci. 85 1996 725 731 (Pubitemid 26234677)
10. I.J. Hardy, A. Windberg-Baarup, C. Neri, P.V. Byway, S.W. Booth, and S. Fitzpatrick Modulation of drug release kinetics from hydroxypropyl methyl cellulose matrix tablets using polyvinyl pyrrolidone Int. J. Pharm. 337 2007 246 253 (Pubitemid 46756059)
11. S. Jamzad, L. Tutunji, and R. Fassihi Analysis of macromolecular changes and drug release from hydrophilic matrix systems Int. J. Pharm. 292 2005 75 85 (Pubitemid 40255790)
12. S.G. Kazarian, and J. Van der Weerd Simultaneous FTIR spectroscopic imaging and visible photography to monitor tablet dissolution and drug release Pharm. Res. 25 2008 853 860 (Pubitemid 351661828)
13. R. Konrad, A. Christ, G. Zessin, and U. Cobet The use of ultrasound and penetrometer to characterize the advancement of swelling and eroding fronts in HPMC matrices Int. J. Pharm. 163 1998 123 131 (Pubitemid 28162626)
14. P.R. Laity, and M.D. Mantle Magnetic resonance imaging and X-ray microtomography studies of a gel-forming tablet formulation Eur. J. Pharm. Biopharm. 74 1 2010 109 119
15. C.L. Li, L.G. Martini, J.L. Ford, and M. Roberts The use of hypromellose in oral drug delivery J. Pharm. Pharmacol. 57 2005 533 546 (Pubitemid 40562392)
16. W.Y. Li, A. Woldu, L. Araba, and D. Winstead Determination of water penetration and drug concentration profiles in HPMC-based matrix tablets by near infrared chemical imaging J. Pharm. Sci. 99 7 2010 3081 3088
17. C.D. Melia Hydrophilic matrix sustained-release systems based on polysaccharide carriers Crit. Rev. Ther. Drug Carrier Syst. 8 1991 395 421
18. K.P. Nott Magnetic resonance imaging of tablet dissolution Eur. J. Pharm. Biopharm. 74 1 2010 78 83
19. N.A. Peppas, and J.J. Sahlin A simple equation for the description of solute release: III. Coupling of diffusion and relaxation Int. J. Pharm. 57 1989 169 172 (Pubitemid 20011841)
20. S.R. Pygall, S. Kujawinski, P. Timmins, and C.D. Melia Mechanisms of drug release in citrate buffered HPMC matrices Int. J. Pharm. 370 2009 110 120
21. S.R. Pygall, J. Whetstone, P. Timmins, and C.D. Melia Pharmaceutical applications of confocal laser scanning microscopy: the physical characterisation of pharmaceutical systems Adv. Drug Deliv. Rev. 59 14 2007 1434 1452 (Pubitemid 350130271)
22. J.C. Richardson, R.W. Bowtell, K. Mader, and C.D. Melia Pharmaceutical applications of magnetic resonance imaging (MRI) Adv. Drug Deliv. Rev. 57 2005 1191 1209 (Pubitemid 40797574)
23. J. Siepmann, and N.A. Peppas Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC) Adv. Drug Deliv. Rev. 48 2001 139 157 (Pubitemid 32434400)
24. F. Tajorabi, S. Abrahmsen-Alami, M. Hansen, and A. Larsson The impact of dose and solubility of additives on the release from HPMC matrix tablets - identifying critical conditions Pharm. Res. 26 6 2009 1496 1503
25. D. Vesely Diffusion of liquids in polymers Int. Mater. Rev. 53 5 2008 299 315
26. H.D. Williams, R. Ward, I.J. Hardy, and C.D. Melia The extended release properties of HPMC matrices in the presence of dietary sugars J. Control. Release 138 2009 251 259
27. H.D. Williams, R. Ward, A. Culy, I.J. Hardy, and C.D. Melia Designing HPMC matrices with improved resistance to dissolved sugar Int. J. Pharm. 401 2010 51 59