The impact of dose and solubility of additives on the release from HPMC matrix tablets-identifying critical conditions

Pharmaceutical Research

Volumn 26, Issue 6, 2009, Pages 1496-1503

  Tajarobi, Farhad ^a,b   Abrahmsén Alami, Susanna ^a   Hansen, Magnus ^b   Larsson, Anette ^b  

^a ASTRAZENECA R AND D   (Sweden)

^b CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

Author keywords

Drug load; HPMC; Percolation threshold; Release robustness; Solubility

Indexed keywords

CALCIUM PHOSPHATE DIBASIC; DRUG ADDITIVE; HYDROXYPROPYLMETHYLCELLULOSE; MANNITOL;

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED RELEASE FORMULATION; DIFFUSION; DISSOLUTION; DRUG RELEASE; HYDRODYNAMICS; MATRIX TABLET; PERCOLATION THRESHOLD; PRIORITY JOURNAL; TABLET DISINTEGRATION; TABLET POROSITY; WATER TRANSPORT;

CALCIUM PHOSPHATES; DIFFUSION; EXCIPIENTS; LACTOSE; MANNITOL; METHYLCELLULOSE; POROSITY; SOLUBILITY; TABLETS;

EID: 67349129067     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-009-9861-y     Document Type: Article

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