The extended release properties of HPMC matrices in the presence of dietary sugars

Journal of Controlled Release

Volumn 138, Issue 3, 2009, Pages 251-259

  Williams, Hywel D ^a   Ward, Robert ^b   Hardy, Ian J ^c   Melia, Colin D ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b Merck Sharp & Dohme Limited   (United Kingdom)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Extended release; Hydroxypropyl methylcellulose; Matrix; Release mechanism; Sugars

Indexed keywords

BARRIER PROPERTIES; D-FRUCTOSE; D-GALACTOSE; D-GLUCOSE; DRUG RELEASE; DRUG RELEASE KINETICS; EXTENDED RELEASE; GEL LAYER FORMATION; GEL STRUCTURES; GEL-DIFFUSION; HIGH CONCENTRATION; HYDROXYL NUMBER; HYDROXYPROPYL METHYLCELLULOSE; MATRIX; RELEASE MECHANISM; SOL-GEL TRANSITIONS; SOLUTE CONCENTRATIONS; STRUCTURE ACTIVITY RELATIONSHIPS; STRUCTURE-ACTIVITY; SUGAR CONCENTRATION; WATER STRUCTURE;

CHARGE TRAPPING; COALESCENCE; CONCENTRATION (PROCESS); DISSOLUTION; ELECTRIC RESISTANCE; FRUCTOSE; GELATION; GELS; GLUCOSE;

SUGAR (SUCROSE);

CAFFEINE; FRUCTOSE; GALACTOSE; GLUCOSE; LACTOSE; METHYLCELLULOSE; SUCROSE;

ARTICLE; CHEMICAL STRUCTURE; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DIFFUSION; HYDRATION; OSMOTIC PRESSURE; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; SUGAR INTAKE; TRANSITION TEMPERATURE; VISCOSITY;

CAFFEINE; CARBOHYDRATES; DELAYED-ACTION PREPARATIONS; DIFFUSION; GELS; METHYLCELLULOSE; MOLECULAR STRUCTURE; PHARMACEUTICAL PREPARATIONS; PHASE TRANSITION; SOLUBILITY; SUCROSE;

EID: 68749089533     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2009.05.017     Document Type: Article

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