Should subchondral bone turnover be targeted when treating osteoarthritis?

Osteoarthritis and Cartilage

Volumn 16, Issue 6, 2008, Pages 638-646

  Karsdal, M A ^a   Leeming, D J ^a   Dam, E B ^a   Henriksen, K ^a   Alexandersen, P ^b   Pastoureau, P ^c   Altman, R D ^d   Christiansen, C ^a  

^a NORDIC BIOSCIENCE A S   (Denmark)

^b CENTER FOR CLINICAL AND BASIC RESEARCH   (Denmark)

^c INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Bone; Cartilage; Chondrocytes; Osteoarthritis; Osteoclasts; Phenotype; Sclerosis; Subchondral; Turnover

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; CALCITONIN; CENTCHROMAN; ESTROGEN; SELECTIVE ESTROGEN RECEPTOR MODULATOR; ZOLEDRONIC ACID;

BIOMECHANICS; BONE MARROW DISEASE; BONE TURNOVER; CARTILAGE CELL; CARTILAGE DEGENERATION; CHONDROPROTECTION; CLINICAL TRIAL; DISEASE COURSE; DRUG MECHANISM; DRUG TARGETING; ESTROGEN THERAPY; HUMAN; MEDLINE; NONHUMAN; OSTEOARTHRITIS; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; OSTEOPHYTE; OSTEOSCLEROSIS; PAGET BONE DISEASE; PHENOTYPE; PRIORITY JOURNAL; PROCESS OPTIMIZATION; REVIEW; SINGLE DRUG DOSE; TRABECULAR BONE;

ANIMALS; BIOMECHANICS; BONE DENSITY CONSERVATION AGENTS; BONE REMODELING; BONE RESORPTION; CARTILAGE, ARTICULAR; HUMANS; OSTEOARTHRITIS; OSTEOBLASTS; OSTEOCLASTS;

EID: 44549084860     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2008.01.014     Document Type: Review

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