The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in sheep and goats

Osteoarthritis and Cartilage

Volumn 18, Issue SUPPL. 3, 2010, Pages

  Little, C B ^a   Smith, M M ^a   Cake, M A ^b   Read, R A ^b   Murphy, M J ^c   Barry, F P ^c  

^a UNIVERSITY OF SYDNEY   (Australia)

^b MURDOCH UNIVERSITY   (Australia)

^c NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

Animal model; Histopathology; Osteoarthritis; Sheep and goats

Indexed keywords

ANIMAL ANATOMY; ARTICLE; CHONDROPATHY; DISEASE MODEL; FEMUR; GOAT; HISTOPATHOLOGY; KNEE LIGAMENT; KNEE MENISCUS; KNEE OSTEOARTHRITIS; MANKIN SCORING SYSTEM; NONHUMAN; OSTEOPHYTE; PATHOLOGICAL ANATOMY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; SCORING SYSTEM; SHEEP; SPECIES COMPARISON; STANDARDIZATION; SYNOVITIS; TIBIA;

ANIMALS; ARTHRITIS, EXPERIMENTAL; CARTILAGE, ARTICULAR; DISEASE MODELS, ANIMAL; GOATS; JOINTS; OSTEOARTHRITIS; SEVERITY OF ILLNESS INDEX; SHEEP; SYNOVIAL MEMBRANE;

EID: 77956907233     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2010.04.016     Document Type: Article

References (65)

1. Alini M., Eisenstein S.M., Ito K., Little C., Kettler A.A., Masuda K., et al. Are animal models useful for studying human disc disorders/degeneration?. Eur Spine J 2008, 17(1):2-19.
2. Turner A.S. Experiences with sheep as an animal model for shoulder surgery: strengths and shortcomings. J Shoulder Elbow Surg 2007.
3. Drespe I.H., Polzhofer G.K., Turner A.S., Grauer J.N. Animal models for spinal fusion. Spine J 2005, 5(6 Suppl.):209S-216.
4. Turner A.S. Animal models of osteoporosis-necessity and limitations. Eur Cell Mater 2001, 1:66-81.
5. Wilke H.J., Kettler A., Claes L.E. Are sheep spines a valid biomechanical model for human spines?. Spine 1997, 22(20):2365-2374.
6. Laurent D., Wasvary J., Rudin M., O'Byrne E., Pellas T. In vivo assessment of macromolecular content in articular cartilage of the goat knee. Magn Reson Med 2003, 49(6):1037-1046.
7. Cesana M., Appleyard R., Jones H., Murrell G. The effect of chronic ACL deficiency on the secondary restraints of the knee: a biomechanical study in a sheep model. Trans Orth Res Soc 2003, 28:803.
8. Ho C., Cervilla V., Kjellin I., Haghigi P., Amiel D., Trudell D., et al. Magnetic resonance imaging in assessing cartilage changes in experimental osteoarthrosis of the knee. Invest Radiol 1992, 27(1):84-90.
9. Rorvik A.M., Teige J. Unstable stifles without clinical or radiographic osteoarthritis in young goats: an experimental study. Acta Vet Scand 1996, 37(3):265-272.
10. Scherer M.A., Metak G., Haas B., Hammerschmid E., von Gumppenberg S. [Glycosaminoglycans as markers of post-traumatic gonarthrosis?]. Chirurg 1998, 69(1):82-90.
11. Hunt P., Scheffler S.U., Unterhauser F.N., Weiler A. A model of soft-tissue graft anterior cruciate ligament reconstruction in sheep. Arch Orthop Trauma Surg 2005, 125(4):238-248.
12. Burger C., Kabir K., Mueller M., Rangger C., Minor T., Tolba R.H. Retropatellar chondromalacia associated with medial osteoarthritis after meniscus injury. One year of observations in sheep. Eur Surg Res 2006, 38(2):102-108.
13. Simpson D., Bellenger C., Ghosh P., Numata Y., Little C. The effect of total meniscectomy versus caudal pole hemimeniscectomy on the stifle joint of the sheep. Vet Comp Orthop Traumatol 1999, 12:56-63.
14. Armstrong S.J., Read R.A., Ghosh P., Wilson D.M. Moderate exercise exacerbates the osteoarthritic lesions produced in cartilage by meniscectomy: a morphological study. Osteoarthritis Cartilage 1993, 1(2):89-96.
15. Ghosh P., Burkhardt D., Read R., Bellenger C. Recent advances in animal models for evaluating chondroprotective drugs. J Rheumatol Suppl 1991, 27:143-146.
16. Ghosh P., Sutherland J., Bellenger C., Read R., Darvodelsky A. The influence of weight-bearing exercise on articular cartilage of meniscectomized joints. An experimental study in sheep. Clin Orthop Relat Res 1990, (252):101-113.
17. Armstrong S., Read R., Ghosh P. The effects of intraarticular hyaluronan on cartilage and subchondral bone changes in an ovine model of early osteoarthritis. J Rheumatol 1994, 21(4):680-688.
18. Ghosh P., Holbert C., Read R., Armstrong S. Hyaluronic acid (hyaluronan) in experimental osteoarthritis. J Rheumatol Suppl 1995, 43:155-157.
19. Ghosh P., Numata Y., Smith S., Read R., Armstrong S., Johnson K. The metabolic response of articular cartilage to abnormal mechanical loading induced by medial or lateral meniscectomy. Joint destruction in arthritis and osteoarthritis 1993, 89-93. Birkhauser Verlag, Basel. W. van der Berg, P.M. van der Kraan, P.L. van Lent (Eds.).
20. Ghosh P., Read R., Armstrong S., Wilson D., Marshall R., McNair P. Semin Arthritis Rheum. The effects of intraarticular administration of hyaluronan in a model of early osteoarthritis in sheep. I. Gait analysis and radiological and morphological studies 1993, 22(6 Suppl. 1):18-30.
21. Ghosh P., Read R., Numata Y., Smith S., Armstrong S., Wilson D. The effects of intraarticular administration of hyaluronan in a model of early osteoarthritis in sheep. II. Cartilage composition and proteoglycan metabolism. Semin Arthritis Rheum 1993, 22(6 Suppl. 1):31-42.
22. Little C., Smith S., Ghosh P., Bellenger C. Histomorphological and immunohistochemical evaluation of joint changes in a model of osteoarthritis induced by lateral meniscectomy in sheep. J Rheumatol 1997, 24(11):2199-2209.
23. Little C.B., Ghosh P., Bellenger C.R. Topographic variation in biglycan and decorin synthesis by articular cartilage in the early stages of osteoarthritis: an experimental study in sheep. J. Orthop. Res 1996, 14:433-444.
24. Parker D., Hwa S.-Y., Sambrook P., Ghosh P. Estrogen replacement therapy mitigates the loss of joint cartilage proteoglycans and bone mineral density induced by ovariectomy and osteoarthritis. APLAR J Rheumatol 2003, 6:116-127.
25. Oakley S.P., Lassere M.N., Portek I., Szomor Z., Ghosh P., Kirkham B.W., et al. Biomechanical, histologic and macroscopic assessment of articular cartilage in a sheep model of osteoarthritis. Osteoarthritis Cartilage 2004, 12(8):667-679.
26. Cake M.A., Read R.A., Appleyard R.C., Hwa S.Y., Ghosh P. The nitric oxide donor glyceryl trinitrate increases subchondral bone sclerosis and cartilage degeneration following ovine meniscectomy. Osteoarthritis Cartilage 2004, 12(12):974-981.
27. Appleyard R.C., Burkhardt D., Ghosh P., Read R., Cake M., Swain M.V., et al. Topographical analysis of the structural, biochemical and dynamic biomechanical properties of cartilage in an ovine model of osteoarthritis. Osteoarthritis Cartilage 2003, 11(1):65-77.
28. Funakoshi Y., Hariu M., Tapper J.E., Marchuk L.L., Shrive N.G., Kanaya F., et al. Periarticular ligament changes following ACL/MCL transection in an ovine stifle joint model of osteoarthritis. J Orthop Res 2007, 25(8):997-1006.
29. Bylski-Austrow D.I., Malumed J., Meade T., Grood E.S. Knee joint contact pressure decreases after chronic meniscectomy relative to the acutely meniscectomized joint: a mechanical study in the goat. J Orthop Res 1993, 11(6):796-804.
30. Laurent D., O'Byrne E., Wasvary J., Pellas T.C. In vivo MRI of cartilage pathogenesis in surgical models of osteoarthritis. Skeletal Radiol 2006, 35(8):555-564.
31. Murphy J.M., Fink D.J., Hunziker E.B., Barry F.P. Stem cell therapy in a caprine model of osteoarthritis. Arthritis Rheum 2003, 48(12):3464-3474.
32. Cake M.A., Read R.A., Guillou B., Ghosh P. Modification of articular cartilage and subchondral bone pathology in an ovine meniscectomy model of osteoarthritis by avocado and soya unsaponifiables (ASU). Osteoarthritis Cartilage 2000, 8(6):404-411.
33. Smith M.M., Cake M.A., Ghosh P., Schiavinato A., Read R.A., Little C.B. Significant synovial pathology in a meniscectomy model of osteoarthritis: modification by intra-articular hyaluronan therapy. Rheumatology (Oxford) 2008, 47(8):1172-1178.
34. Kelly B.T., Potter H.G., Deng X.H., Pearle A.D., Turner A.S., Warren R.F., et al. Meniscal allograft transplantation in the sheep knee: evaluation of chondroprotective effects. Am J Sports Med 2006, 34(9):1464-1477.
35. Allen M.J., Houlton J.E., Adams S.B., Rushton N. The surgical anatomy of the stifle joint in sheep. Vet Surg 1998, 27(6):596-605.
36. Frisbie D.D., Cross M.W., McIlwraith C.W. A comparative study of articular cartilage thickness in the stifle of animal species used in human pre-clinical studies compared to articular cartilage thickness in the human knee. Vet Comp Orthop Traumatol 2006, 19(3):142-146.
37. Cake M.A., Appleyard R.C., Read R.A., Smith M.M., Murrell G.A., Ghosh P. Ovariectomy alters the structural and biomechanical properties of ovine femoro-tibial articular cartilage and increases cartilage iNOS. Osteoarthritis Cartilage 2005, 13:1066-1075.
38. Turner A.S., Athanasiou K.A., Zhu C.F., Alvis M.R., Bryant H.U. Biochemical effects of estrogen on articular cartilage in ovariectomized sheep. Osteoarthritis Cartilage 1997, 5(1):63-69.
39. Ghosh P. Role of biomechanical factors. Osteoarthritis: clinical and experimental aspects 1999, 115-133. Springer-Verlag, Berlin. J.Y. Reginster, J.-P. Pelletier, J. Martel-Pelletier, Y. Henrotin (Eds.).
40. Ghosh P., Armstrong S., Read R., Numata Y., Smith S., McNair P., et al. Animal models of early osteoarthritis: their use for the evaluation of potential chondroprotective agents. Agents Actions Suppl 1993, 39:195-206.
41. Ghosh P., Sutherland J.M., Taylor T.K., Pettit G.D., Bellenger C.R. The effects of postoperative joint immobilization on articular cartilage degeneration following meniscectomy. J Surg Res 1983, 35(6):461-473.
42. Mankin H.J., Dorfman H., Lippiello L., Zarins A. Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg Am 1971, 53(3):523-537.
43. Pritzker K.P., Gay S., Jimenez S.A., Ostergaard K., Pelletier J.P., Revell P.A., et al. Osteoarthritis cartilage histopathology: grading and staging. Osteoarthritis Cartilage 2006, 14(1):13-29.
44. Custers R.J., Creemers L.B., Verbout A.J., van Rijen M.H., Dhert W.J., Saris D.B. Reliability, reproducibility and variability of the traditional Histologic/Histochemical Grading System vs the new OARSI Osteoarthritis Cartilage Histopathology Assessment System. Osteoarthritis Cartilage 2007, 15:1241-1248.
45. Little C., Ghosh P. Variation in proteoglycan metabolism by articular chondrocytes in different joint regions is determined by post-natal mechanical loading. Osteoarthritis Cartilage 1997, 5:49-62.
46. Young A., McLennan S., Smith M., Smith S., Cake M., Read R., et al. Decreased expression of PRG4 (lubricin) in an animal model of early osteoarthritis. Arthritis Res Ther 2006, 8:R41-R46.
47. Young A.A., Appleyard R.C., Smith M.M., Melrose J., Little C.B. Dynamic biomechanics correlate with histopathology in human tibial cartilage: a preliminary study. Clin Orthop Relat Res 2007.
48. Young A.A., Smith M., Smith S., Burkhardt D., Appleyard R.C., Coolican M., et al. In situ topographical assessment of osteoarthritic human knee articular cartilage using a handheld indentation probe. Trans Orthop Res Soc 2004, 923.
49. Melrose J., Smith S.M., Smith M.M., Little C.B. The use of Histochoice for histological examination of articular and growth plate cartilages, intervertebral disc and meniscus. Biotech Histochem 2008, 83(1):47-53.
50. Melrose J., Ghosh P., Taylor T.K. A comparative analysis of the differential spatial and temporal distributions of the large (aggrecan, versican) and small (decorin, biglycan, fibromodulin) proteoglycans of the intervertebral disc. J Anat 2001, 198(Pt 1):3-15.
51. Melrose J., Smith S., Ghosh P. Histological and immunohistological studies on cartilage. Methods Mol Med 2004, 101:39-64.
52. Melrose J., Smith S., Ghosh P., Taylor T.K. Differential expression of proteoglycan epitopes and growth characteristics of intervertebral disc cells grown in alginate bead culture. Cells Tissues Organs 2001, 168(3):137-146.
53. Melrose J., Smith S., Little C., Kitson J., Hwa S., Ghosh P. Spatial and temporal localization of transforming growth factor-beta, fibroblast growth factor-2, and osteonectin, and identification of cells expressing alpha-smooth muscle actin in the injured anulus fibrosus: implications for extracellular matrix repair. Spine 2002, 27:1756-1764.
54. Young A.A., Smith M.M., Smith S.M., Cake M.A., Ghosh P., Read R.A., et al. Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis. Arthritis Res Ther 2005, 7(4):R852-R861.
55. Getzy L.L., Malemud C.J., Moskowitz R.W. Factors influencing metachromatic staining in paraffin embedded sections of rabbit and human articular cartilage: a comparison of the safranin O and toluidine blue O technics. J Histotechnology 1982, 5:111-116.
56. Hwa S.Y., Burkhardt D., Little C., Ghosh P. The effects of orally administered diacerein on cartilage and subchondral bone in an ovine model of osteoarthritis. J Rheumatol 2001, 28(4):825-834.
57. Hope N., Ghosh P., Taylor T.K., Sun D., Read R. Effects of intraarticular hyaluronan on matrix changes induced in the lateral meniscus by total medial meniscectomy and exercise. Semin Arthritis Rheum 1993, 22(6 Suppl. 1):43-51.
58. Smith M., Cake M., Smith S., Ghosh P., Read R. A nodified histopathological scoring system to detect the effects of intraarticular hyaluronan (Hylagan) on synovial patholgy in an ovine model of osteoarthritis. Trans Orth Res Soc 2004, 29:933.
59. Smith M., Reno C., Ghosh P., Cake M., Read R., Hart D. The effects of intraarticular hyaluronan (Hyalgan+) on gene expression by the anterior cruciate ligament in an ovine meniscectomy model of osteoarthritis. Trans Comb Orthop Res Soc 2004, 5:65.
60. Watkins M.W. MacKappa (computer software) 1998, Pennsylvania State University.
61. Cake M., Read R., Edwards S., Smith M.M., Burkhardt D., Little C., et al. Changes in gait after bilateral meniscectomy in sheep: effect of two hyaluronan preparations. J Orthop Sci 2008, 13(6):514-523.
62. Oakley S.P., Portek I., Szomor Z., Appleyard R.C., Ghosh P., Kirkham B.W., et al. Arthroscopy - a potential " gold standard" for the diagnosis of the chondropathy of early osteoarthritis. Osteoarthritis Cartilage 2005, 13(5):368-378.
63. Eckstein F., Mosher T., Hunter D. Imaging of knee osteoarthritis: data beyond the beauty. Curr Opin Rheumatol 2007, 19(5):435-443.
64. Rousseau J.C., Delmas P.D. Biological markers in osteoarthritis. Nat Clin Pract Rheumatol 2007, 3(6):346-356.
65. Bauer D.C., Hunter D.J., Abramson S.B., Attur M., Corr M., Felson D., et al. Classification of osteoarthritis biomarkers: a proposed approach. Osteoarthritis Cartilage 2006, 14(8):723-727.