The Wnt antagonist Dickkopf-1 is regulated by Bmp signaling and c-Jun and modulates programmed cell death

EMBO Journal

Volumn 21, Issue 5, 2002, Pages 966-975

  Grotewold, Lars ^a   Rüther, Ulrich ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Apoptosis; Bmp; c Jun; Dkk 1; Limb development

Indexed keywords

BETA CATENIN; GLYCOPROTEIN; PROTEIN C JUN; WNT PROTEIN;

ARTICLE; CELL DEATH; CHICKEN; EMBRYO; GENOTOXICITY; LIMB BUD; LIMB DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; XENOPUS;

ANIMALS; APOPTOSIS; BETA CATENIN; BONE MORPHOGENETIC PROTEINS; CARRIER PROTEINS; CHICK EMBRYO; CYTOSKELETAL PROTEINS; DNA-BINDING PROTEINS; DRUG IMPLANTS; ENZYME INHIBITORS; EXTREMITIES; FIBROBLAST GROWTH FACTOR 8; FIBROBLAST GROWTH FACTORS; FIBROBLASTS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEDGEHOG PROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LYMPHOID ENHANCER-BINDING FACTOR 1; MESODERM; MICE; MICE, KNOCKOUT; MORPHOGENESIS; PROTEIN BIOSYNTHESIS; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-JUN; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; STAUROSPORINE; TRANS-ACTIVATORS; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTORS; ULTRAVIOLET RAYS; WING; WNT PROTEINS; ZEBRAFISH PROTEINS;

GALLUS GALLUS; VERTEBRATA;

EID: 0036500653     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/21.5.966     Document Type: Article

References (60)

1. Distortion of proximodistal information causes JNK-dependent apoptosis in Drosophila wing
2. The jun protooncogene is positively autoregulated by its product, Jun/AP1
3. Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation
4. Wnt signaling: An embarrassment of receptors
5. Induction of apoptosis by the transcription factor c-Jun
6. Antagonistic effects of FGF4 on BMP induction of apoptosis and chondrogenesis in the chick limb bud
7. Expression profile of Gli family members and Shh in normal and mutant mouse limb development
8. 2-induced cell death
9. Wnt signaling: A common theme in animal development
10. Molecular mechanism of staurosporine-induced apoptosis in osteoblasts
11. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
12. JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
13. Overexpression of BMP-2 and BMP-4 alters the size and shape of developing skeletal elements in the chick limb
14. Transforming growth factor-β 1 induces apoptosis independently of p53 and selectively reduces expression of Bcl-2 in multipotent hematopoietic cells
15. Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction
16. Expression pattern of Dkk-1 during mouse limb development
17. Bambi is coexpressed with Bmp-4 during mouse embryogenesis
18. Dual roles of Wnt signaling during chondrogenesis in the chicken limb
19. Syndactyly of Ft/+ mice correlates with an imbalance in Bmp4 and Fgf8 expression
20. c-Jun is essential for normal mouse development and hepatogenesis
21. Morphology and significance of programmed cell death in the developing limb bud of the vertebrate embryo
22. The TAK1-NLK-MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF
23. Differential induction of c-fos, c-jun and apoptosis in lung epithelial cells exposed to ROS or RNS
24. WNT signals control FGF-dependent limb initiation and AER induction in the chick embryo
25. BMP-2 induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6
26. The stress-activated protein kinase subfamily of c-Jun kinases
27. Siah-1 mediates a novel β-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein
28. Role of BMP-2 and OP-1 (BMP-7) in programmed cell death and skeletogenesis during chick limb development
29. LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
30. Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway
31. Msx2 is a transcriptional regulator in the BMP4-mediated programmed cell death pathway
32. The roles of FGFs in the early development of vertebrate limbs
33. Inhibition of Wnt activity induces heart formation from posterior mesoderm
34. TGFβ signaling in growth control, cancer and heritable disorders
35. Siah-1, SIP and Ebi collaborate in a novel pathway for β-catenin degradation linked to p53 responses
36. Role of FGFs in the control of programmed cell death during limb development
37. Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse
38. Axin-induced apoptosis depends on the extend of its JNK activation and its ability to down-regulate β-catenin levels
39. c-Jun interacts with the corepressor TG-interacting factor (TGIF) to suppress Smad2 transcriptional activity
40. BMPs negatively regulate structure and function of the limb apical ectodermal ridge
41. Wnt signaling and cancer
42. Mode of cell injury and death after hydrogen peroxide exposure in cultured oligodendroglia cells
43. Protein kinase C inhibitor and irradiation-induced apoptosis: Relevance of the cytochrome c-mediated caspase-9 death pathway
44. Pattern of expression of the Jun family of transcription factors during the early development of the inner ear: Implications in apoptosis
45. Autoregulation of Shh expression and Shh induction of cell death suggest a mechanism for modulating polarising activity during chick limb development
46. Immediate early up-regulation of bax expression by p53 but not TGF β 1: A paradigm for distinct apoptotic pathways
47. The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest
48. Role of TAK1 and TAB1 in BMP signaling in early Xenopus development
49. Zebrafish Dkk1, induced by the pre-MBT Wnt signaling, is secreted from the prechordal plate and patterns the anterior neural plate
50. TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development
51. Surfing the p53 network
52. Dickkopf-1, an inhibitor of the Wnt signaling pathway, is induced by p53
53. Tissue-specific expression of c-jun and junB during organogenesis in the mouse
54. Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor β
55. Transforming growth factor-β 1 induces apoptosis in gastric cancer cells through a p53-independent pathway
56. BMP-2/-4 mediate programmed cell death in chicken limb buds
57. TAK1 is activated in the myocardium after pressure overload and is sufficient to provoke heart failure in transgenic mice
58. Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription
59. Wnt signaling: Antagonistic Dickkopfs
60. BMP signaling and vertebrate limb development