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Volumn 11, Issue 6, 2011, Pages 698-713

Novel approaches to target pancreatic cancer

Author keywords

Epidermal growth factor receptor inhibitor; Farnesyl transferase inhibitor; Mammalian target of rapamycin; Matrix metalloproteinase inhibitor; Notch; Pancreatic cancer; Sonic hedgehog; Targeted therapy; Vascular endothelial growth factor inhibitor

Indexed keywords

ANGIOGENESIS INHIBITOR; AXITINIB; BEVACIZUMAB; CAPECITABINE; CETUXIMAB; CISPLATIN; CONATUMUMAB; DOCETAXEL; ERLOTINIB; EVEROLIMUS; FLUOROPYRIMIDINE; FLUOROURACIL; GANITUMAB; GEMCITABINE; GI 4000; IRINOTECAN; MAMMALIAN TARGET OF RAPAMYCIN; MARIMASTAT; MK 0752; NOTCH RECEPTOR; OXALIPLATIN; PACLITAXEL; RAPAMYCIN; SONIC HEDGEHOG PROTEIN; SORAFENIB; TANOMASTAT; TEMSIROLIMUS; TIPIFARNIB; TRASTUZUMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VISMODEGIB;

EID: 79959933116     PISSN: 15680096     EISSN: 18735576     Source Type: Journal    
DOI: 10.2174/156800911796191079     Document Type: Article
Times cited : (8)

References (66)
  • 1
    • 77954986682 scopus 로고    scopus 로고
    • Risk of cancer following hospitalization for type 2 diabetes
    • Hemminki, K.; Li, X.; Sundquist, J.; Sundquist, K. Risk of cancer following hospitalization for type 2 diabetes. Oncologist 2010, 15 (6), 548-555.
    • (2010) Oncologist , vol.15 , Issue.6 , pp. 548-555
    • Hemminki, K.1    Li, X.2    Sundquist, J.3    Sundquist, K.4
  • 6
    • 0028985078 scopus 로고
    • Treatment and survival in 13,560 patients with pancreatic cancer, and incidence of the disease, in the West Midlands: An epidemiological study
    • Bramhall, S. R.; Allum, W. H.; Jones, A. G.; Allwood, A.; Cummins, C.; Neoptolemos, J. P. Treatment and survival in 13,560 patients with pancreatic cancer, and incidence of the disease, in the West Midlands: an epidemiological study. Br. J. Surg. 1995, 82 (1), 111-115.
    • (1995) Br. J. Surg , vol.82 , Issue.1 , pp. 111-115
    • Bramhall, S.R.1    Allum, W.H.2    Jones, A.G.3    Allwood, A.4    Cummins, C.5    Neoptolemos, J.P.6
  • 7
    • 1642588228 scopus 로고    scopus 로고
    • Pancreatic cancer
    • Li, D.; Xie, K.; Wolff, R.; Abbruzzese, J. L. Pancreatic cancer. Lancet 2004, 363 (9414), 1049-1057.
    • (2004) Lancet , vol.363 , Issue.9414 , pp. 1049-1057
    • Li, D.1    Xie, K.2    Wolff, R.3    Abbruzzese, J.L.4
  • 8
    • 0035424135 scopus 로고    scopus 로고
    • Marimastat as first-line therapy for patients with unresectable pancreatic cancer: A randomized trial
    • Bramhall, S. R.; Rosemurgy, A.; Brown, P. D.; Bowry, C.; Buckels, J. A. Marimastat as first-line therapy for patients with unresectable pancreatic cancer: a randomized trial. J. Clin. Oncol. 2001, 19 (15), 3447-3455.
    • (2001) J. Clin. Oncol , vol.19 , Issue.15 , pp. 3447-3455
    • Bramhall, S.R.1    Rosemurgy, A.2    Brown, P.D.3    Bowry, C.4    Buckels, J.A.5
  • 9
    • 0037100983 scopus 로고    scopus 로고
    • A double-blind placebo-controlled, randomized study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer
    • Bramhall, S. R.; Schulz, J.; Nemunaitis, J.; Brown, P. D.; Baillet, M.; Buckels, J. A. A double-blind placebo-controlled, randomized study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer. Br. J. Cancer 2002, 87 (2), 161-167.
    • (2002) Br. J. Cancer , vol.87 , Issue.2 , pp. 161-167
    • Bramhall, S.R.1    Schulz, J.2    Nemunaitis, J.3    Brown, P.D.4    Baillet, M.5    Buckels, J.A.6
  • 10
    • 0141688333 scopus 로고    scopus 로고
    • Comparison of gemcitabine versus the matrix metalloproteinase inhibitor BAY 12-9566 in patients with advanced or metastatic adenocarcinoma of the pancreas: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    • Moore, M. J.; Hamm, J.; Dancey, J.; Eisenberg, P. D.; Dagenais, M.; Fields, A.; Hagan, K.; Greenberg, B.; Colwell, B.; Zee, B.; Tu, D.; Ottaway, J.; Humphrey, R.; Seymour, L. Comparison of gemcitabine versus the matrix metalloproteinase inhibitor BAY 12-9566 in patients with advanced or metastatic adenocarcinoma of the pancreas: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J. Clin. Oncol. 2003, 21 (17), 3296-3302.
    • (2003) J. Clin. Oncol , vol.21 , Issue.17 , pp. 3296-3302
    • Moore, M.J.1    Hamm, J.2    Dancey, J.3    Eisenberg, P.D.4    Dagenais, M.5    Fields, A.6    Hagan, K.7    Greenberg, B.8    Colwell, B.9    Zee, B.10    Tu, D.11    Ottaway, J.12    Humphrey, R.13    Seymour, L.14
  • 12
    • 23844517889 scopus 로고    scopus 로고
    • A phase II study of farnesyl transferase inhibitor R115777 in pancreatic cancer: A Southwest oncology group (SWOG 9924) study
    • Macdonald, J. S.; McCoy, S.; Whitehead, R. P.; Iqbal, S.; Wade, J. L., 3rd; Giguere, J. K.; Abbruzzese, J. L. A phase II study of farnesyl transferase inhibitor R115777 in pancreatic cancer: a Southwest oncology group (SWOG 9924) study. Invest. New Drugs 2005, 23 (5), 485-487.
    • (2005) Invest. New Drugs , vol.23 , Issue.5 , pp. 485-487
    • Macdonald, J.S.1    McCoy, S.2    Whitehead, R.P.3    Iqbal, S.4    Wade, J.L.5    Giguere, J.K.6    Abbruzzese, J.L.7
  • 14
    • 0344637004 scopus 로고    scopus 로고
    • Systemic activation of the vascular endothelial growth factor receptor KDR/flk-1 selectively triggers endothelial cells with an angiogenic phenotype
    • Ortega, N.; Jonca, F.; Vincent, S.; Favard, C.; Ruchoux, M. M.; Plouet, J. Systemic activation of the vascular endothelial growth factor receptor KDR/flk-1 selectively triggers endothelial cells with an angiogenic phenotype. Am. J. Pathol. 1997, 151 (5), 1215-1224.
    • (1997) Am. J. Pathol , vol.151 , Issue.5 , pp. 1215-1224
    • Ortega, N.1    Jonca, F.2    Vincent, S.3    Favard, C.4    Ruchoux, M.M.5    Plouet, J.6
  • 15
    • 0032963472 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF)-mediated angiogenesis is associated with enhanced endothelial cell survival and induction of Bcl-2 expression
    • Nor, J. E.; Christensen, J.; Mooney, D. J.; Polverini, P. J. Vascular endothelial growth factor (VEGF)-mediated angiogenesis is associated with enhanced endothelial cell survival and induction of Bcl-2 expression. Am. J. Pathol. 1999, 154 (2), 375-384.
    • (1999) Am. J. Pathol , vol.154 , Issue.2 , pp. 375-384
    • Nor, J.E.1    Christensen, J.2    Mooney, D.J.3    Polverini, P.J.4
  • 16
    • 0032907687 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) and its receptors
    • Neufeld, G.; Cohen, T.; Gengrinovitch, S.; Poltorak, Z. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J. 1999, 13 (1), 9-22.
    • (1999) FASEB J , vol.13 , Issue.1 , pp. 9-22
    • Neufeld, G.1    Cohen, T.2    Gengrinovitch, S.3    Poltorak, Z.4
  • 18
    • 50249087586 scopus 로고    scopus 로고
    • A phase II study evaluating bevacizumab in combination with fixed-dose rate gemcitabine and low-dose cisplatin for metastatic pancreatic cancer: Is an anti-VEGF strategy still applicable?
    • Ko, A. H.; Dito, E.; Schillinger, B.; Venook, A. P.; Xu, Z.; Bergsland, E. K.; Wong, D.; Scott, J.; Hwang, J.; Tempero, M. A. A phase II study evaluating bevacizumab in combination with fixed-dose rate gemcitabine and low-dose cisplatin for metastatic pancreatic cancer: is an anti-VEGF strategy still applicable? Invest. New Drugs 2008, 26 (5), 463-471.
    • (2008) Invest. New Drugs , vol.26 , Issue.5 , pp. 463-471
    • Ko, A.H.1    Dito, E.2    Schillinger, B.3    Venook, A.P.4    Xu, Z.5    Bergsland, E.K.6    Wong, D.7    Scott, J.8    Hwang, J.9    Tempero, M.A.10
  • 19
    • 67349250514 scopus 로고    scopus 로고
    • Bevacizumab combined with gemcitabine and capecitabine for advanced pancreatic cancer: A phase II study
    • Javle, M.; Yu, J.; Garrett, C.; Pande, A.; Kuvshinoff, B.; Litwin, A.; Phelan, J., 3rd; Gibbs, J.; Iyer, R. Bevacizumab combined with gemcitabine and capecitabine for advanced pancreatic cancer: a phase II study. Br. J. Cancer 2009, 100 (12), 1842-1845.
    • (2009) Br. J. Cancer , vol.100 , Issue.12 , pp. 1842-1845
    • Javle, M.1    Yu, J.2    Garrett, C.3    Pande, A.4    Kuvshinoff, B.5    Litwin, A.6    Phelan, J.7    Gibbs, J.8    Iyer, R.9
  • 23
    • 0034163550 scopus 로고    scopus 로고
    • Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas
    • Frederick, L.; Wang, X. Y.; Eley, G.; James, C. D. Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas. Cancer Res. 2000, 60 (5), 1383-1387.
    • (2000) Cancer Res , vol.60 , Issue.5 , pp. 1383-1387
    • Frederick, L.1    Wang, X.Y.2    Eley, G.3    James, C.D.4
  • 26
    • 75149144357 scopus 로고    scopus 로고
    • Biweekly gemcitabine (GEM) in combination with erlotinib (ERL): An active and convenient regimen for advanced pancreatic cancer
    • Ardavanis, A.; Kountourakis, P.; Karagiannis, A.; Doufexis, D.; Tzovaras, A. A.; Rigatos, G. Biweekly gemcitabine (GEM) in combination with erlotinib (ERL): an active and convenient regimen for advanced pancreatic cancer. Anticancer Res. 2009, 29 (12), 5211-5217.
    • (2009) Anticancer Res , vol.29 , Issue.12 , pp. 5211-5217
    • Ardavanis, A.1    Kountourakis, P.2    Karagiannis, A.3    Doufexis, D.4    Tzovaras, A.A.5    Rigatos, G.6
  • 28
    • 4344590997 scopus 로고    scopus 로고
    • Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: A multicenter phase II Trial
    • Xiong, H. Q.; Rosenberg, A.; LoBuglio, A.; Schmidt, W.; Wolff, R. A.; Deutsch, J.; Needle, M.; Abbruzzese, J. L. Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: a multicenter phase II Trial. J. Clin. Oncol. 2004, 22 (13), 2610-2616.
    • (2004) J. Clin. Oncol , vol.22 , Issue.13 , pp. 2610-2616
    • Xiong, H.Q.1    Rosenberg, A.2    Lobuglio, A.3    Schmidt, W.4    Wolff, R.A.5    Deutsch, J.6    Needle, M.7    Abbruzzese, J.L.8
  • 37
    • 70349974840 scopus 로고    scopus 로고
    • Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer
    • Bailey, J. M.; Mohr, A. M.; Hollingsworth, M. A. Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer. Oncogene 2009, 28 (40), 3513-3525.
    • (2009) Oncogene , vol.28 , Issue.40 , pp. 3513-3525
    • Bailey, J.M.1    Mohr, A.M.2    Hollingsworth, M.A.3
  • 38
    • 58149506283 scopus 로고    scopus 로고
    • GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation
    • Nolan-Stevaux, O.; Lau, J.; Truitt, M. L.; Chu, G. C.; Hebrok, M.; Fernandez-Zapico, M. E.; Hanahan, D. GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation. Genes Dev. 2009, 23 (1), 24-36.
    • (2009) Genes Dev , vol.23 , Issue.1 , pp. 24-36
    • Nolan-Stevaux, O.1    Lau, J.2    Truitt, M.L.3    Chu, G.C.4    Hebrok, M.5    Fernandez-Zapico, M.E.6    Hanahan, D.7
  • 39
    • 72949103044 scopus 로고    scopus 로고
    • Small-molecule modulators of the Sonic Hedgehog signaling pathway
    • Stanton, B. Z.; Peng, L. F. Small-molecule modulators of the Sonic Hedgehog signaling pathway. Mol. Biosyst. 2010 6, (1), 44-54.
    • (2010) Mol. Biosyst , vol.6 , Issue.1 , pp. 44-54
    • Stanton, B.Z.1    Peng, L.F.2
  • 40
    • 33745307617 scopus 로고    scopus 로고
    • Ras, PI(3)K and mTOR signaling controls tumour cell growth
    • Shaw, R. J.; Cantley, L. C. Ras, PI(3)K and mTOR signaling controls tumour cell growth. Nature 2006, 441 (7092), 424-430.
    • (2006) Nature , vol.441 , Issue.7092 , pp. 424-430
    • Shaw, R.J.1    Cantley, L.C.2
  • 41
    • 2342559981 scopus 로고    scopus 로고
    • The TOR pathway: A target for cancer therapy
    • Bjornsti, M. A.; Houghton, P. J. The TOR pathway: a target for cancer therapy. Nat. Rev. Cancer 2004, 4 (5), 335-348.
    • (2004) Nat. Rev. Cancer , vol.4 , Issue.5 , pp. 335-348
    • Bjornsti, M.A.1    Houghton, P.J.2
  • 42
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • Hay, N.; Sonenberg, N. Upstream and downstream of mTOR. Genes Dev. 2004, 18 (16), 1926-1945.
    • (2004) Genes Dev , vol.18 , Issue.16 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 43
    • 0033178702 scopus 로고    scopus 로고
    • Regulation of cell growth and cyclin D1 expression by the constitutively active FRAP-p70s6K pathway in human pancreatic cancer cells
    • Grewe, M.; Gansauge, F.; Schmid, R. M.; Adler, G.; Seufferlein, T. Regulation of cell growth and cyclin D1 expression by the constitutively active FRAP-p70s6K pathway in human pancreatic cancer cells. Cancer Res. 1999, 59 (15), 3581-3587.
    • (1999) Cancer Res , vol.59 , Issue.15 , pp. 3581-3587
    • Grewe, M.1    Gansauge, F.2    Schmid, R.M.3    Adler, G.4    Seufferlein, T.5
  • 44
    • 0348049845 scopus 로고    scopus 로고
    • Incidence, mechanism and prognostic value of activated AKT in pancreas cancer
    • Schlieman, M. G.; Fahy, B. N.; Ramsamooj, R.; Beckett, L.; Bold, R. J. Incidence, mechanism and prognostic value of activated AKT in pancreas cancer. Br. J. Cancer 2003, 89 (11), 2110-2115.
    • (2003) Br. J. Cancer , vol.89 , Issue.11 , pp. 2110-2115
    • Schlieman, M.G.1    Fahy, B.N.2    Ramsamooj, R.3    Beckett, L.4    Bold, R.J.5
  • 49
    • 0142259346 scopus 로고    scopus 로고
    • The role of Notch in tumorigenesis: Oncogene or tumour suppressor?
    • Radtke, F.; Raj, K. The role of Notch in tumorigenesis: oncogene or tumour suppressor? Nat. Rev. Cancer. 2003, 3 (10), 756-767.
    • (2003) Nat. Rev. Cancer , vol.3 , Issue.10 , pp. 756-767
    • Radtke, F.1    Raj, K.2
  • 50
    • 33747623018 scopus 로고    scopus 로고
    • Notch signalling: A simple pathway becomes complex
    • Bray, S. J. Notch signalling: a simple pathway becomes complex. Nat. Rev. Mol. Cell Biol. 2006, 7 (9), 678-689.
    • (2006) Nat. Rev. Mol. Cell Biol , vol.7 , Issue.9 , pp. 678-689
    • Bray, S.J.1
  • 51
    • 33846236394 scopus 로고    scopus 로고
    • The multifaceted role of Notch in cancer
    • Roy, M.; Pear, W. S.; Aster, J. C. The multifaceted role of Notch in cancer. Curr. Opin. Genet. Dev. 2007, 17 (1), 52-59.
    • (2007) Curr. Opin. Genet. Dev , vol.17 , Issue.1 , pp. 52-59
    • Roy, M.1    Pear, W.S.2    Aster, J.C.3
  • 52
    • 0037363922 scopus 로고    scopus 로고
    • HES and HERP families: Multiple effectors of the Notch signaling pathway
    • Iso, T.; Kedes, L.; Hamamori, Y. HES and HERP families: multiple effectors of the Notch signaling pathway. J. Cell Physiol. 2003, 194 (3), 237-255.
    • (2003) J. Cell Physiol , vol.194 , Issue.3 , pp. 237-255
    • Iso, T.1    Kedes, L.2    Hamamori, Y.3
  • 53
    • 34248139757 scopus 로고    scopus 로고
    • The Hes gene family: Repressors and oscillators that orchestrate embryogenesis
    • Kageyama, R.; Ohtsuka, T.; Kobayashi, T. The Hes gene family: repressors and oscillators that orchestrate embryogenesis. Development 2007, 134 (7), 1243-1251.
    • (2007) Development , vol.134 , Issue.7 , pp. 1243-1251
    • Kageyama, R.1    Ohtsuka, T.2    Kobayashi, T.3
  • 56
    • 37649023286 scopus 로고    scopus 로고
    • Matrix metalloproteinase 7 controls pancreatic acinar cell transdifferentiation by activating the Notch signaling pathway
    • Sawey, E. T.; Johnson, J. A.; Crawford, H. C. Matrix metalloproteinase 7 controls pancreatic acinar cell transdifferentiation by activating the Notch signaling pathway. Proc. Natl. Acad. Sci. U. S. A. 2007, 104 (49), 19327-19332.
    • (2007) Proc. Natl. Acad. Sci. U. S. A , vol.104 , Issue.49 , pp. 19327-19332
    • Sawey, E.T.1    Johnson, J.A.2    Crawford, H.C.3
  • 59
    • 70249130566 scopus 로고    scopus 로고
    • Phase II study of bevacizumab with concurrent capecitabine and radiation followed by maintenance gemcitabine and bevacizumab for locally advanced pancreatic cancer: Radiation Therapy Oncology Group RTOG 0411
    • Crane, C. H.; Winter, K.; Regine, W. F.; Safran, H.; Rich, T. A.; Curran, W.; Wolff, R. A.; Willett, C. G. Phase II study of bevacizumab with concurrent capecitabine and radiation followed by maintenance gemcitabine and bevacizumab for locally advanced pancreatic cancer: Radiation Therapy Oncology Group RTOG 0411. J. Clin. Oncol. 2009, 27 (25), 4096-4102.
    • (2009) J. Clin. Oncol , vol.27 , Issue.25 , pp. 4096-4102
    • Crane, C.H.1    Winter, K.2    Regine, W.F.3    Safran, H.4    Rich, T.A.5    Curran, W.6    Wolff, R.A.7    Willett, C.G.8    Phase, I.I.9
  • 60
    • 79955620158 scopus 로고    scopus 로고
    • Phase II trial of full-dose gemcitabine and bevacizumab in combination with attenuated three-dimensional conformal radiotherapy in patients with localized pancreatic cancer
    • Small, W., Jr.; Mulcahy, M. F.; Rademaker, A.; Bentrem, D. J.; Benson, A. B.; Weitner, B. B.; Talamonti, M. S. Phase II trial of full-dose gemcitabine and bevacizumab in combination with attenuated three-dimensional conformal radiotherapy in patients with localized pancreatic cancer. Int. J. Radiat. Oncol. Biol. Phys. 2011, 80 (2), 476-482.
    • (2011) Int. J. Radiat. Oncol. Biol. Phys , vol.80 , Issue.2 , pp. 476-482
    • Small Jr., W.1    Mulcahy, M.F.2    Rademaker, A.3    Bentrem, D.J.4    Benson, A.B.5    Weitner, B.B.6    Talamonti, M.S.7
  • 63
    • 84864369720 scopus 로고    scopus 로고
    • A phase II trial of erlotinib in combination with gemcitabine and capecitabine in previously untreated metastatic/recurrent pancreatic cancer: Combined analysis with translational research
    • Oh, D. Y.; Lee, K. W.; Lee, K. H.; Sohn, C. H.; Park, Y. S.; Zang, D. Y.; Ryoo, H. M.; Song, H. S.; Kim, J. S.; Kang, H. J.; Kim, B. S.; Bang, Y. J. A phase II trial of erlotinib in combination with gemcitabine and capecitabine in previously untreated metastatic/recurrent pancreatic cancer: combined analysis with translational research. Invest. New Drugs. 2011.
    • (2011) Invest. New Drugs
    • Oh, D.Y.1    Lee, K.W.2    Lee, K.H.3    Sohn, C.H.4    Park, Y.S.5    Zang, D.Y.6    Ryoo, H.M.7    Song, H.S.8    Kim, J.S.9    Kang, H.J.10    Kim, B.S.11    Bang, Y.J.12


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