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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 14, 2011, Pages 4238-4242

Small molecule inhibitors of SHP2 tyrosine phosphatase discovered by virtual screening

(6) Yu, Zhi Hong a Chen, Lan a Wu, Li a Liu, Sijiu a Wang, Lina a Zhang, Zhong Yin a

a INDIANA UNIVERSITY SCHOOL OF MEDICINE (United States)

Author keywords

Drug discovery; Molecular dynamics simulation; Protein tyrosine phosphatase (PTP); SHP2 inhibitor; Virtual screening

Indexed keywords

PROTEIN TYROSINE PHOSPHATASE INHIBITOR; PROTEIN TYROSINE PHOSPHATASE SHP 2;

ARTICLE; CONTROLLED STUDY; DRUG BINDING; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; IC 50; IN VITRO STUDY; MOLECULAR DYNAMICS; MUTAGENESIS; PROCESS OPTIMIZATION; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; BENZENESULFONATES; BINDING SITES; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; KINETICS; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11; PYRAZOLES; SEQUENCE ALIGNMENT; SMALL MOLECULE LIBRARIES; SRC HOMOLOGY DOMAINS; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 79959910681 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.05.078 Document Type: Article

Times cited : (18)

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