Impact of fusion to Gα i2 and co-expression with RGS proteins on pharmacological properties of human cannabinoid receptors CB 1R and CB 2R

Journal of Pharmacy and Pharmacology

Volumn 63, Issue 8, 2011, Pages 1043-1055

  Sutor, Sarah ^a   Heilmann, Jörg ^a   Seifert, Roland ^b  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Cannabinoid receptors; Fusion proteins; G protein coupled receptors; RGS proteins; Steady state GTPase assay

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; 1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N MORPHOLINO 1H PYRAZOLE 3 CARBOXAMIDE; 2 ARACHIDONOYLGLYCEROL; 2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 6 IODO 3 (4 METHOXYBENZOYL) 2 METHYL 1 (2 MORPHOLINOETHYL)INDOLE; ANANDAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID 1 RECEPTOR GUANINE NUCLEOTIDE BINDING ALPHA I2 FUSION PROTEIN; CANNABINOID 2 RECEPTOR; CANNABINOID 2 RECEPTOR GUANINE NUCLEOTIDE BINDING ALPHA I2 FUSION PROTEIN; COMPLEMENTARY DNA; CP 55 940; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA I2 SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA 1 GAMMA 2 SUBUNIT; HEXAHISTIDINE; HYBRID PROTEIN; RGS PROTEIN; RGS19 PROTEIN; RGS4 PROTEIN; UNCLASSIFIED DRUG; WIN 55 212 2;

ANIMAL CELL; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; INSECT CELL; INTRACELLULAR SIGNALING; NONHUMAN; PROTEIN EXPRESSION; PROTEIN HYDROLYSIS; STEADY STATE;

CELL LINE; GTP PHOSPHOHYDROLASES; GTP-BINDING PROTEIN ALPHA SUBUNITS; HUMANS; LIGANDS; PROTEIN BINDING; RECEPTORS, CANNABINOID; RECEPTORS, G-PROTEIN-COUPLED; RECOMBINANT FUSION PROTEINS; RGS PROTEINS;

EID: 79959903488     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2011.01307.x     Document Type: Article

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