N-Acylhydrazones as inhibitors of PDE10A

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 14, 2011, Pages 4155-4159

  Gage, Jennifer L ^a   Onrust, Rene ^a   Johnston, Derek ^b   Osnowski, Andrew ^b   MacDonald, Wendy ^b   Mitchell, Lee ^b   Ürögdi, László ^c   Rohde, Alex ^a   Harbol, Kevin ^a   Gragerov, Sasha ^a   Dormán, György ^c   Wheeler, Tom ^a   Florio, Vince ^a   Cutshall, Neil S ^a  

^a OMEROS CORPORATION   (United States)

^b Scottish Biomedical   (United Kingdom)

^c AMRI Hungary Zrt   (Hungary)

Author keywords

Acylhydrazone; Enzyme inhibitor; Hydrazide; Hydrazone; PDE; PDE10; PDE10A; Phosphodiesterase; Schizophrenia

Indexed keywords

CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 10A; HYDRAZONE DERIVATIVE; N ACYLHYDRAZONE DERIVATIVE; PHOSPHODIESTERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AVOIDANCE BEHAVIOR; CONTROLLED STUDY; DRUG ABSORPTION; DRUG CLEARANCE; DRUG STABILITY; DRUG SYNTHESIS; ENZYME INHIBITION; MOUSE; NONHUMAN; RAT; SCHIZOPHRENIA;

ANIMALS; DISEASE MODELS, ANIMAL; HUMANS; HYDRAZONES; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; QUINOLINES; RATS; SCHIZOPHRENIA; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 79959902275     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.05.100     Document Type: Article

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