Water-mediated binding of agents that target the DNA minor groove

Journal of the American Chemical Society

Volumn 133, Issue 26, 2011, Pages 10171-10183

  Liu, Yang ^a   Kumar, Arvind ^a   Depauw, Sabine ^b,c   Nhili, Raja ^b,c   David Cordonnier, Marie Heél̀ne ^b,c   Lee, Michael P ^d   Ismail, Mohamed A ^a   Farahat, Abdelbasset A ^a   Say, Martial ^a   Chackal Catoen, Sarah ^a   Batista Parra, Adalgisa ^a   Neidle, Stephen ^d   Boykin, David W ^a   Wilson, W David ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

^b Institut de Recherche sur le Cancer de Lille   (France)

^c UNIV LILLE   (France)

^d UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BENZIMIDAZOLES; BOUND WATER MOLECULES; CHEMICAL BIOLOGY; CLASSICAL MODEL; DNA COMPLEX; FOOTPRINTING; ISOTHERMAL TITRATION MICROCALORIMETRY; LINEAR CONFORMATION; META POSITIONS; MINOR GROOVES; PARA POSITION; PLASMON RESONANCES; RADIUS OF CURVATURE; SMALL MOLECULES; SYNTHETIC MODIFICATIONS; THERAPEUTIC APPLICATION; WATER MOLECULE; X RAY CRYSTAL STRUCTURES;

BIOSENSORS; COMPLEXATION; CRYSTAL STRUCTURE; DICHROISM; MOLECULES; SCAFFOLDS (BIOLOGY); SURFACE PLASMON RESONANCE; X RAY CRYSTALLOGRAPHY;

DNA;

AMIDINE; DEOXYRIBONUCLEASE I; DNA; WATER;

ARTICLE; BINDING AFFINITY; BIOSENSOR; CHEMICAL MODIFICATION; CIRCULAR DICHROISM; CRYSTAL STRUCTURE; DNA FOOTPRINTING; GENE TARGETING; ISOTHERMAL TITRATION CALORIMETRY; KINETICS; MOLECULE; SURFACE PLASMON RESONANCE; THERMODYNAMICS; X RAY; X RAY CRYSTALLOGRAPHY;

AMIDINES; BASE SEQUENCE; BENZIMIDAZOLES; BINDING SITES; DEOXYRIBONUCLEASE I; DNA; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR WEIGHT; NUCLEIC ACID CONFORMATION; SURFACE PLASMON RESONANCE; THERMODYNAMICS; WATER;

EID: 79959864191     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja202006u     Document Type: Article

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