FOXP3 mRNA expression analysis in the peripheral blood and allograft of heart transplant patients

Transplant Immunology

Volumn 18, Issue 3, 2008, Pages 250-254

  Dijke, I Esmé ^a   Caliskan, Kadir ^a   Korevaar, Sander S ^a   Maat, Alex P W M ^a   Zondervan, Pieter E ^a   Balk, Aggie H M M ^a   Weimar, Willem ^a   Baan, Carla C ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Endomyocardial biopsies; FOXP3 gene expression; Heart transplantation; Peripheral blood

Indexed keywords

MESSENGER RNA; TRANSCRIPTION FACTOR FOXP3;

ADULT; ARTICLE; BLOOD; CARDIAC GRAFT REJECTION; CLINICAL ARTICLE; FEMALE; GENE EXPRESSION; HEART MUSCLE BIOPSY; HEART TRANSPLANTATION; HUMAN; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL;

ADULT; AGED; BIOPSY; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; MYOCARDIUM; RNA, MESSENGER;

EID: 36348945194     PISSN: 09663274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trim.2007.08.001     Document Type: Article

References (24)

1. Fontenot J.D., Gavin M.A., and Rudensky A.Y. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 4 4 (2003) 330-336
2. Bettelli E., Dastrange M., and Oukka M. Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells. Proc Natl Acad Sci U S A 102 14 (2005) 5138-5143
3. Yagi H., Nomura T., Nakamura K., et al. Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells. Int Immunol 16 11 (2004) 1643-1656
4. Cobbold S.P., Castejon R., Adams E., et al. Induction of foxP3+ regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants. J Immunol 172 10 (2004) 6003-6010
5. Lee I., Wang L., Wells A.D., Dorf M.E., Ozkaynak E., and Hancock W.W. Recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor. J Exp Med 201 7 (2005) 1037-1044
6. Baan C.C., van der Mast B.J., Klepper M., et al. Differential effect of calcineurin inhibitors, anti-cd25 antibodies and rapamycin on the induction of FOXP3 in human T cells. Transplantation 80 1 (2005) 110-117
7. Dijke I.E., Velthuis J.H., Caliskan K., et al. Intragraft FOXP3 mRNA expression reflects antidonor immune reactivity in cardiac allograft patients. Transplantation 83 11 (2007) 1477-1484
8. Muthukumar T., Dadhania D., Ding R., et al. Messenger RNA for FOXP3 in the urine of renal-allograft recipients. N Engl J Med 353 22 (2005) 2342-2351
9. Stewart S., Winters G.L., Fishbein M.C., et al. Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection. J Heart Lung Transplant 24 11 (2005) 1710-1720
10. Dijke I.E., Velthuis J.H., Balk A.H., et al. Donor-specific cytotoxic hyporesponsiveness associated with high interleukin-10 messenger RNA expression in cardiac allograft patients. J Heart Lung Transplant 25 8 (2006) 955-964
11. Vaessen L.M., Baan C.C., Ouwehand A.J., et al. Acute rejection in heart transplant patients is associated with the presence of committed donor-specific cytotoxic lymphocytes in the graft but not in the blood. Clin Exp Immunol 88 2 (1992) 213-219
12. DeBruyne L.A., Ensley R.D., Olsen S.L., et al. Increased frequency of alloantigen-reactive helper T lymphocytes is associated with human cardiac allograft rejection. Transplantation 56 3 (1993) 722-727
13. Hernandez-Fuentes M.P., Warrens A.N., and Lechler R.I. Immunologic monitoring. Immunol Rev 196 (2003) 247-264
14. van Besouw N.M., Zuijderwijk J.M., Vaessen L.M., et al. The direct and indirect allogeneic presentation pathway during acute rejection after human cardiac transplantation. Clin Exp Immunol 141 3 (2005) 534-540
15. Hu H., Robertus M., de Jonge N., et al. Reduction of donor-specific cytotoxic T lymphocyte precursors in peripheral blood of allografted heart recipients. Transplantation 58 11 (1994) 1263-1268
16. Van Hoffen E., Polen E., Robertus-Teunissen M., et al. High frequency of IL-4 producing helper T lymphocytes associated with a reduced incidence of heart allograft rejection. Transpl Int 13 Suppl 1 (2000) S216-S224
17. Horwitz P.A., Tsai E.J., Putt M.E., et al. Detection of cardiac allograft rejection and response to immunosuppressive therapy with peripheral blood gene expression. Circulation 110 25 (2004) 3815-3821
18. Schoels M., Dengler T.J., Richter R., Meuer S.C., and Giese T. Detection of cardiac allograft rejection by real-time PCR analysis of circulating mononuclear cells. Clin Transplant 18 5 (2004) 513-517
19. Deng M.C., Eisen H.J., Mehra M.R., et al. Noninvasive discrimination of rejection in cardiac allograft recipients using gene expression profiling. Am J Transplant 6 1 (2006) 150-160
20. Melter M., Exeni A., Reinders M.E., et al. Expression of the chemokine receptor CXCR3 and its ligand IP-10 during human cardiac allograft rejection. Circulation 104 21 (2001) 2558-2564
21. Shulzhenko N., Morgun A., Zheng X.X., et al. Intragraft activation of genes encoding cytotoxic T lymphocyte effector molecules precedes the histological evidence of rejection in human cardiac transplantation. Transplantation 72 10 (2001) 1705-1708
22. Ozkaynak E., Wang L., Goodearl A., et al. Programmed death-1 targeting can promote allograft survival. J Immunol 169 11 (2002) 6546-6553
23. Halloran P.F., Reeve J., and Kaplan B. Lies, damn lies, and statistics: the perils of the P value. Am J Transplant 6 1 (2006) 10-11
24. Vlad G., Ho E.K., Vasilescu E.R., et al. Anti-CD25 treatment and FOXP3-positive regulatory T cells in heart transplantation. Transpl Immunol 18 1 (2007) 13-21