Kinetic analysis reveals potency of CD4+ CD25bright+ regulatory T-cells in kidney transplant patients

Transplant Immunology

Volumn 18, Issue 2, 2007, Pages 159-165

  Velthuis, J H L ^a   Hesselink, D A ^a   Hendrikx, T K ^a   van der Mast, B J ^a   Klepper, M ^a   de Greef, G E ^a   Baan, C C ^a   Weimar, W ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Human; Kidney transplantation; Regulatory T cells

Indexed keywords

ANTIGEN; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; TACROLIMUS;

ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL ASSAY; CELL ISOLATION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; INCUBATION TIME; KIDNEY GRAFT; KINETICS; MALE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE;

ANTIGENS, CD4; COCULTURE TECHNIQUES; HUMANS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; KIDNEY TRANSPLANTATION; LYMPHOCYTE ACTIVATION; MALE; T-LYMPHOCYTES, REGULATORY; TISSUE DONORS; TRANSPLANTATION TOLERANCE;

EID: 36048936015     PISSN: 09663274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trim.2007.05.009     Document Type: Article

References (26)

1. + regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 22 (2004) 531
2. Sakaguchi S., Sakaguchi N., Asano M., Itoh M., and Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 155 (1995) 1151
3. Ehrenstein M.R., Evans J.G., Singh A., Moore S., Warnes G., Isenberg D.A., et al. Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy. J Exp Med 200 (2004) 277
4. +CD25bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis. J Immunol 172 (2004) 6435
5. Lindley S., Dayan C.M., Bishop A., Roep B.O., Peakman M., and Tree T.I. Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes. Diabetes 54 (2005) 92
6. Graca L., Cobbold S.P., and Waldmann H. Identification of regulatory T cells in tolerated allografts. J Exp Med 195 (2002) 1641
7. Akl A., Luo S., and Wood K.J. Induction of transplantation tolerance-the potential of regulatory T cells. Transpl Immunol 14 (2005) 225
8. + regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses. J Immunol 168 (2002) 1080
9. Hara M., Kingsley C.I., Niimi M., Read S., Turvey S.E., Bushell A.R., et al. IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo. J Immunol 166 (2001) 3789
10. Li Y., Koshiba T., Yoshizawa A., Yonekawa T., Masuda K., Ito A., et al. Analyses of peripheral blood mononuclear cells in operational tolerance after pediatric living donor liver transplantation. Am J Transplant 4 (2004) 2118
11. + T cells/FOXP3 patterns in chronic rejection and operational drug-free tolerance. Transplantation 81 (2006) 398
12. + regulatory T cells in operational tolerance after living donor liver transplantation. Transplant Proc 37 (2005) 37
13. VanBuskirk A.M., Burlingham W.J., Jankowska-Gan E., Chin T., Kusaka S., Geissler F., et al. Human allograft acceptance is associated with immune regulation. J Clin Invest 106 (2000) 145
14. Mason P.D., Robinson C.M., and Lechler R.I. Detection of donor-specific hyporesponsiveness following late failure of human renal allografts. Kidney Int 50 (1996) 1019
15. Hornick P.I., Mason P.D., Yacoub M.H., Rose M.L., Batchelor R., and Lechler R.I. Assessment of the contribution that direct allorecognition makes to the progression of chronic cardiac transplant rejection in humans. Circulation 97 (1998) 1257
16. Baker R.J., Hernandez-Fuentes M.P., Brookes P.A., Chaudhry A.N., Cook H.T., and Lechler R.I. Loss of direct and maintenance of indirect alloresponses in renal allograft recipients: implications for the pathogenesis of chronic allograft nephropathy. J Immunol 167 (2001) 7199
17. van Besouw N.M., van der Mast B.J., de Kuiper P., Smak Gregoor P.J., Vaessen L.M., IJzermans J.N., et al. Donor-specific T-cell reactivity identifies kidney transplant patients in whom immunosuppressive therapy can be safely reduced. Transplantation 70 (2000) 136
18. van der Mast B.J., Rischen-Vos J., de Kuiper P., Vaessen L.M., van Besouw N.M., and Weimar W. Calcineurin inhibitor withdrawal in stable kidney transplant patients decreases the donor-specific cytotoxic T lymphocyte precursor frequency. Transplantation 80 (2005) 1220
19. Smak Gregoor P.J., van Gelder T., van Besouw N.M., van der Mast B.J., IJzermans J.N., and Weimar W. Randomized study on the conversion of treatment with cyclosporine to azathioprine or mycophenolate mofetil followed by dose reduction. Transplantation 70 (2000) 143
20. bright+ regulatory T-cells can mediate donor non-reactivity in long-term immunosuppressed kidney allograft patients. Am J Transplant 6 (2006) 2955
21. Wood K.J., and Sakaguchi S. Regulatory T cells in transplantation tolerance. Nat Rev Immunol 3 (2003) 199
22. + regulatory T cells do not significantly contribute to direct pathway hyporesponsiveness in stable renal transplant patients. J Am Soc Nephrol 14 (2003) 1652
23. + regulatory T cells. Blood 107 (2006) 1018
24. + cells in vitro. Am J Transplant 5 (2005) 454
25. Lakkis F.G., and Sayegh M.H. Memory T cells: a hurdle to immunologic tolerance. J Am Soc Nephrol 14 (2003) 2402
26. Wang J., Ioan-Facsinay A., van der Voort E.I., Huizinga T.W., and Toes R.E. Transient expression of FOXP3 in human activated nonregulatory CD4(+) T cells. Eur J Immunol 37 (2007) 129