Forkhead box P3 (FOXP3) mRNA expression immediately after living-donor liver transplant

Experimental and Clinical Transplantation

Volumn 7, Issue 1, 2009, Pages 8-12

  Sakamoto, Rieko ^a   Asonuma, Katsuhiro ^a   Ramirez, Manuel E Zeledon ^b   Yoshimoto, Kazuhiko ^a   Nishimori, Aya ^a   Inomata, Yukihiro ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b Hospital Calderon Guardia   (Costa Rica)

Author keywords

Acute cellular rejection; Forkhead box P3; Immunosuppression; Liver transplant; RegulatoryT cells

Indexed keywords

BILIRUBIN; MESSENGER RNA; TRANSCRIPTION FACTOR FOXP3; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 2 RECEPTOR ALPHA;

ACUTE GRAFT REJECTION; ARTICLE; BILIRUBIN BLOOD LEVEL; CD4+ CD25+ T LYMPHOCYTE; CELL ACTIVITY; CELL SELECTION; CLINICAL ARTICLE; GENE EXPRESSION; GRAFT RECIPIENT; HUMAN; LIVER TRANSPLANTATION; LIVING DONOR; LYMPHOCYTE SUBPOPULATION; PERIPHERAL BLOOD MONONUCLEAR CELL; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; ADOLESCENT; ADULT; AGED; BLOOD; FEMALE; GENETICS; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOLOGY; INFANT; MALE; MIDDLE AGED; PRESCHOOL CHILD; TIME; TRANSPLANTATION TOLERANCE; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; CHILD, PRESCHOOL; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GRAFT REJECTION; GRAFT SURVIVAL; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFANT; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LIVER TRANSPLANTATION; LIVING DONORS; MALE; MIDDLE AGED; RNA, MESSENGER; T-LYMPHOCYTES, REGULATORY; TIME FACTORS; TRANSPLANTATION TOLERANCE; TREATMENT OUTCOME; YOUNG ADULT;

EID: 67649222381     PISSN: 13040855     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Bluestone JA, Abbas AK. Natural versus adaptive regulatory T cells. Nat Rev Immunol. 2003;3(3):253-257.
2. Sakaguchi S, Sakaguchi N, Shimizu J, et al. Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol Rev. 2001;182:18-32.
3. Jonuleit H, Schmitt E, Stassen M, et al. Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood. J Exp Med. 2001;193(11):1285-1294.
4. Valmori D, Merlo A, Souleimanian NE, et al. A peripheral circulating compartment of natural naive CD4 Tregs. J Clin Invest. 2005;115(7):1953-1962.
5. Wood KJ, Sakaguchi S. Regulatory T cells in transplantation tolerance. Nat Rev Immunol. 2003;3(3):199-210.
6. Yoshizawa A, Ito A, Li Y, et al. The roles of CD25+CD4+ regulatory T cells in operational tolerance after living donor liver transplantation. Transplant Proc. 2005;37(1):37-39.
7. Demirkiran A, Kok A, Kwekkeboom J, et al. Decrease of CD4+CD25+ T cells in peripheral blood after liver transplantation: association with immunosuppression. Transplant Proc. 2005;37(2):1194-1196.
8. Demirkiran A, Kok A, KwekkeboomJ, et al. Low circulating regulatory T-cell levels after acute rejection in liver transplantation. Liver Transpl. 2006;12(2):277-284.
9. Sakaguchi S. The origin of FOXP3-expression CD4+ regulatory T cells: thymus or periphery. J Clin Invest. 2003;112(9):1310-1312.
10. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science. 2003;299(5609):1057-1061.
11. Allan SE, Passerini L, Bacchetta R, et al. The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs. J Clin Invest. 2005;115(11):3276-3284.
12. Allan SE, Crome SQ, Crellin NK, et al. Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production. Int Immunol. 2007;19(4):345-354.
13. Ormonde DG, de Boer WB, Kierath A, et al. Banff schema for grading liver allograft rejection: utility in clinical practice. Liver Transpl Surg. 1999;5(4):261-268.
14. Ziegler SF. FOXP3: not just for regulatory T cells anymore. Eur J Immunol. 2007;37(1):21-23.
15. Morgan ME, van Bilsen JH, Bakker AM, et al. Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans. Hum Immunol. 2005;66(1):13-20.
16. Gavin MA, Torgerson TR, Houston E, et al. Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development [published correction appears in Proc Natl Acad Sci U S A. 2006;103(24):9373]. Proc Natl Acad Sci U S A. 2006;103(17):6659-6664.
17. Bloom DD, Chang Z, Fechner JH, et al. CD4+ CD25+ FOXP3+ regulatory T cells increase de novo in kidney transplant patients after immunodepletion with Campath-1H. Am J Transplant. 2008;8(4):793-802.