Clinical significance of regulatory T-cell-related gene expression in peripheral blood after renal transplantation

Transplantation

Volumn 91, Issue 2, 2011, Pages 191-198

  Iwase, Hayato ^a   Kobayashi, Takaaki ^a   Kodera, Yasuhiro ^a   Miwa, Yuko ^a   Kuzuya, Takafumi ^a   Iwasaki, Kenta ^a   Haneda, Masataka ^a   Katayama, Akio ^b   Takeda, Asami ^c   Morozumi, Kunio ^c   Watarai, Yoshihiko ^c   Uchida, Kazuharu ^c   Nakao, Akimasa ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Masuko Memorial Hospital   (Japan)

^c NAGOYA DAINI RED CROSS HOSPITAL   (Japan)

Author keywords

Foxp3; Kidney transplantation; Regulatory T cell; Tolerance

Indexed keywords

ALPHA MANNOSIDASE; ANTIMETABOLITE; AZATHIOPRINE; BASILIXIMAB; CALCINEURIN INHIBITOR; CHEMOKINE RECEPTOR CCR7; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GRANZYME B; HLA ANTIBODY; MESSENGER RNA; MIZORIBINE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE; PROTEASOME; PROTEASOME SUBUNIT BETA 10; RETINOID RELATED ORPHAN RECEPTOR GAMMA; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CHRONIC GRAFT REJECTION; FEMALE; GENE EXPRESSION; GRAFT RECIPIENT; HEMODIALYSIS; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY T LYMPHOCYTE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; CALCINEURIN; CASE-CONTROL STUDIES; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION; GRAFT REJECTION; GRAFT SURVIVAL; HLA ANTIGENS; HUMANS; ISOANTIBODIES; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; RNA, MESSENGER; T-LYMPHOCYTES, REGULATORY; TRANSPLANTATION TOLERANCE;

EID: 78751648601     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181ffbab4     Document Type: Article

References (41)

1. Salama AD, Womer KL, Sayegh MH. Clinical transplantation tolerance: Many rivers to cross. J Immunol 2007; 178: 5419.
2. Sykes M. Immune tolerance: Mechanisms and application in clinical transplantation. J Intern Med 2007; 262: 288.
3. Sawitzki B, Pascher A, Babel N, et al. Can we use biomarkers and functional assays to implement personalized therapies in transplantation? Transplantation 2009; 87: 1595.
4. Calne RY. Prope tolerance: The future of organ transplantation-From the laboratory to the clinic. Transplantation 2004; 77: 930.
5. + suppressor cell and its mechanisms of action. J Exp Med 1990; 171: 141.
6. Wood KJ, Sakaguchi S. Regulatory T cells in transplantation tolerance. Nat Rev Immunol 2003; 3: 199.
7. + cells regulate CD8 cell anergy in neonatal tolerant mice. Transplantation 1999; 68: 1891.
8. Von Boehmer H. Mechanisms of suppression by suppressor T cells. Nat Immunol 2005; 6: 338.
9. + regulatory cells is mediated by cell surface-bound transforming growth factor beta J Exp Med 2001; 194:629.
10. Mantel PY, Ouaked N, Ruckert B, et al. Molecular mechanisms underlying FOXP3 induction in human T cells. J Immunol 2006; 176: 3593.
11. + regulatory cells at single-cell level. Eur J Immunol 2005; 35: 1681.
12. Zheng Y, JosefowiczSZ, Kas A, etal. Genome-wide analysis ofFoxp3 target genes in developing and mature regulatory T cells. Nature 2007; 445:936.
13. Allan SE, Crome SQ, Crellin NK, et al. Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production. Int Immunol 2007; 19:345.
14. Li Y, Koshiba T, Yoshizawa A, et al. Analyses of peripheral blood mononuclear cells in operational tolerance after pediatric living donor liver transplantation. Am J Transplant 2004; 4: 2118.
15. Martinez-Llordella M, Puig-Pey I, Orlando G, et al. Multiparameter immune profiling of operational tolerance in liver transplantation. Am J Transplant 2007; 7: 309.
16. Koshiba T, Li Y, Takemura M, et al. Clinical, immunological, and pathological aspects of operational tolerance after pediatric living-donor liver transplantation. Transplant Immunol 2007; 17: 94.
17. + regulatory T cells. JExpMed 2007; 204:735.
18. Caramalho I, Lopes-Carvalho T, Ostler D, et al. Regulatory T cells selectively express toll-like receptors and are activated by lipopolysac-charide. J Exp Med 2003; 197: 403.
19. + regulatory cells involves a granzyme B-dependent, perforinindependent mechanism. J Immunol 2005; 174:1783.
20. Long ET, Baker S, Oliveira V, et al. Alpha-1, 2-mannosidase and hence N-glycosylation are required for regulatory T cell migration and allograft tolerance in mice. PLoS ONE 2010; 5: e8894.
21. Ashton-Chess J, Mai HL, Jovanovic V, et al. Immunoproteasome beta subunit 10 is increased in chronic antibody-mediated rejection. Kidney Int 2010; 77: 880.
22. + regulatory T cells. Nat Immunol 2003; 4: 330.
23. Alvarez CM, Opelz G, Garcia LF, et al. Expression of regulatory T-cell-related molecule genes and clinical outcome in kidney transplant recipients. Transplantation 2009; 87: 857.
24. Demirkiran A, Kok A, Kwekkeboom J, et al. Low circulating regulatory T-cell levels after acute rejection in liver transplantation. Liver Transpl 2006; 12: 277.
25. + regulatory T cells in kidney transplantation. TransplantProc 2009; 41: 1527.
26. + regulatory T cells in the induction and maintenance of transplantation tolerance. Transpl Immunol 2007; 17: 120.
27. + regulatory T cells through CTLA-4 signaling. J Immunol 2006; 177: 5631.
28. Kitani A, Chua K, Nakamura K, et al. Activated self-MHC reactive T cells have the cytokine phenotype of Th3/T regulatory cell 1 T cells. J Immunol 2000; 165:691.
29. Kemeny DM, Macary PA. The growing complexity of TGF-beta as a T-cell regulator. Immunology 2005; 114: 459.
30. Hariss S, Coupes BM, Roberts SA, et al. TGF-beta 1 in chronic allograft nephropathy following renal transplantation. J Nephrol 2007; 20: 177.
31. Sawitzki B, Bushell A, Steger U, et al. Identification of gene markers for the prediction of allograft rejection or permanent acceptance. Am J Transplant 2007; 7: 1091.
32. Ashton-Chess J, Dugast E, Colvin RB, et al. Regulatory, effector, and cytotoxic T cell profiles in long-term kidney transplantation patients. J Am Soc Nephrol 2009; 20: 1113.
33. + regulatory T-cell function by calcineurin-dependent interleukin-2 production. Blood 2006; 108: 390.
34. + regulatory T cells in renal transplant recipients. Transplantation 2006; 82: 550.
35. Bann CC, van der Mast BJ, Klepper M, et al. Differential effect of calcineurin inhibitors, anti-CD25 antibodies and rapamycin on the induction of FOXP3 in human T cells. Transplantation 2005; 80: 110.
36. Kobayashi T, Katayama A, Kohara S, et al. Enzyme-linked immunosorbent assay for human leukocyte antigen antibody detection and urine protein test recommended for follow-up monitoring after renal transplantation. Transplantation 2008; 85: 1595.
37. Sagoo P, Perucha E, Sawitzki B, et al. Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans. J Clin Invest 2010; 120: 1848.
38. Newell KA, Asare A, Kirk AD, et al. Identification of a B cell signature associated with renal transplant tolerance in humans. J Clin Invest 2010; 120: 1836.
39. Solez K, Colvin RB, Racusen LC, et al. Banff 05 meeting report: Differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy ('CAN'). Am J Transplant 2007; 7: 518.
40. Solez K, Colvin RB, Racusen LC, et al. Banff 07 classification of renal allograft pathology: Updates and future directions. Am J Transplant 2008; 8: 753.
41. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and 2(-Delat Delta C(T)) method. Methods 2001; 25: 402.