Chk2 and p53 are haploinsufficient with dependent and independent functions to eliminate cells after telomere loss

PLoS Genetics

Volumn 7, Issue 6, 2011, Pages

  Kurzhals, Rebeccah L ^a   Titen, Simon W A ^a   Xie, Heng B ^a   Golic, Kent G ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; PROTEIN P53; RECOMBINASE; DROSOPHILA PROTEIN; LOK PROTEIN, DROSOPHILA; PROTEIN SERINE THREONINE KINASE;

APOPTOSIS; ARTICLE; ASSAY; BAR AND TELOMERE LOSS ASSAY; CELL DIFFERENTIATION; CELL FATE; CELL PROLIFERATION; CELL SURVIVAL; CHROMOSOME 3; CHROMOSOME LOSS; CONTROLLED STUDY; DICENTRIC CHROMOSOME; DROSOPHILA; EYE; FEMALE; GENE; GENE EXPRESSION; GENE MUTATION; HAPLOINSUFFICIENCY; LOK GENE; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; SOMATIC CELL; SOMATIC MULTIPLICATION AFTER RECOMBINASE MEDIATED TELOMERE LOSS ASSAY; TISSUE DIFFERENTIATION; TRANSGENE; TUMOR SUPPRESSOR GENE; WILD TYPE; Y CHROMOSOME; ANIMAL; CELL AGING; GENETICS; HAPLOTYPE; METABOLISM; TELOMERE;

ANIMALIA;

ANIMALS; APOPTOSIS; CELL AGING; DROSOPHILA; DROSOPHILA PROTEINS; GENES, P53; HAPLOTYPES; PROTEIN-SERINE-THREONINE KINASES; TELOMERE;

EID: 79959840870     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002103     Document Type: Article

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