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Volumn 14, Issue 3, 2011, Pages 119-125

Antioxidant and neuroprotective properties of blueberry polyphenols: A critical review

Author keywords

Ageing; Antioxidant; Cognitive functions; Inflammation; Neuroprotection

Indexed keywords

BLUEBERRY EXTRACT; BRAIN DERIVED NEUROTROPHIC FACTOR; N METHYL DEXTRO ASPARTIC ACID; POLYPHENOL; TUMOR NECROSIS FACTOR ALPHA;

EID: 79959823130     PISSN: 1028415X     EISSN: 14768305     Source Type: Journal    
DOI: 10.1179/1476830511Y.0000000007     Document Type: Article
Times cited : (66)

References (49)
  • 2
    • 13844272542 scopus 로고    scopus 로고
    • Reversing the deleterious effects of aging on neuronal communication and behavior: Beneficial properties of fruits polyphenolic compounds
    • Joseph JA, Shukitt-Hale B, Casadesus G. Reversing the deleterious effects of aging on neuronal communication and behavior: beneficial properties of fruits polyphenolic compounds. Am J Clin Nutr 2005;81(Suppl):S313-6.
    • (2005) Am J Clin Nutr , vol.81 , Issue.SUPPL.
    • Joseph, J.A.1    Shukitt-Hale, B.2    Casadesus, G.3
  • 3
    • 0031721802 scopus 로고    scopus 로고
    • Polyphenols: Chemistry, dietary sources, metabolism, and nutritional significante
    • Bravo L. Polyphenols: chemistry, dietary sources, metabolism, and nutritional significante. Nutr Rev 1998;56:317-33.
    • (1998) Nutr Rev , vol.56 , pp. 317-333
    • Bravo, L.1
  • 4
    • 0029888128 scopus 로고    scopus 로고
    • Structure-antioxidant activity relationships of flavonoids and phenolic acids
    • Rice-Evans CA, Miller NJ, Paganga G. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Rad Biol Med 1996;20:933-56.
    • (1996) Free Rad Biol Med , vol.20 , pp. 933-956
    • Rice-Evans, C.A.1    Miller, N.J.2    Paganga, G.3
  • 5
    • 0022567358 scopus 로고
    • Flavonoids in the human diet
    • Pierpoint WS. Flavonoids in the human diet. Prog Clin Biol Res 1986;213:125-40.
    • (1986) Prog Clin Biol Res , vol.213 , pp. 125-140
    • Pierpoint, W.S.1
  • 6
    • 0036233802 scopus 로고    scopus 로고
    • Fruit polyphenolics and brain aging. Nutritional interventions targeting age-related neuronal and behavioral deficits
    • Galli RL, Shukitt-Hale B, Youdim KA, Joseph JA. Fruit polyphenolics and brain aging. Nutritional interventions targeting age-related neuronal and behavioral deficits. Ann NY Acad Sci 2002;959:128-32.
    • (2002) Ann NY Acad Sci , vol.959 , pp. 128-132
    • Galli, R.L.1    Shukitt-Hale, B.2    Youdim, K.A.3    Joseph, J.A.4
  • 7
    • 28444463999 scopus 로고    scopus 로고
    • The beneficial effects of fruit polyphenols on brain aging
    • Lau FC, Shukitt-Hale B, Joseph JA. The beneficial effects of fruit polyphenols on brain aging. Neurobiol Aging 2005; 26(Suppl 1):S128-32.
    • (2005) Neurobiol Aging , vol.26 , Issue.1 SUPPL.
    • Lau, F.C.1    Shukitt-Hale, B.2    Joseph, J.A.3
  • 8
    • 0033462188 scopus 로고    scopus 로고
    • Differential effect of dopamine catabolism and uptake inhibition of dopamine-induced calcium dysregulation and viability loss
    • Cantuti-Castelvetri I, Joseph JA. Differential effect of dopamine catabolism and uptake inhibition of dopamine-induced calcium dysregulation and viability loss. Free Rad Biol Med 1999;27: 1393-404.
    • (1999) Free Rad Biol Med , vol.27 , pp. 1393-1404
    • Cantuti-Castelvetri, I.1    Joseph, J.A.2
  • 9
    • 0032409515 scopus 로고    scopus 로고
    • Aging: Phenomena and theories
    • Harman D. Aging: phenomena and theories. Ann NY Acad Sci 1998;854:1-7.
    • (1998) Ann NY Acad Sci , vol.854 , pp. 1-7
    • Harman, D.1
  • 10
    • 0032704101 scopus 로고    scopus 로고
    • Antioxidants, oxidative stress, and degenerative neurological disorders
    • Floyd RA. Antioxidants, oxidative stress, and degenerative neurological disorders. Proc Soc Exp Biol Med 1999;222: 236-45.
    • (1999) Proc Soc Exp Biol Med , vol.222 , pp. 236-245
    • Floyd, R.A.1
  • 12
    • 0028223426 scopus 로고
    • Free-radical theory of aging. Increasing the functional life span
    • Harman D. Free-radical theory of aging. Increasing the functional life span. Ann NY Acad Sci 1994;717:1-15.
    • (1994) Ann NY Acad Sci , vol.717 , pp. 1-15
    • Harman, D.1
  • 13
    • 0032423287 scopus 로고    scopus 로고
    • Membrane and receptors modification of oxidative stress vulnerability in aging. Nutritional considerations
    • Joseph JA, Denisova N, Fisher D, Shukitt-Hale B, Bickford PC, Prior R, et al. Membrane and receptors modification of oxidative stress vulnerability in aging. Nutritional considerations. Ann NY Acad Sci 1998;854:268-76.
    • (1998) Ann NY Acad Sci , vol.854 , pp. 268-276
    • Joseph, J.A.1    Denisova, N.2    Fisher, D.3    Shukitt-Hale, B.4    Bickford, P.C.5    Prior, R.6
  • 14
    • 0034738347 scopus 로고    scopus 로고
    • Oxidative stress protection and vulnerability in aging: Putative nutritional implications for intervention
    • Joseph JA, Denisova N, Bielinski D, Fisher DR, Shukitt-Hale D. Oxidative stress protection and vulnerability in aging: putative nutritional implications for intervention. Mech Ageing Devel 2000;116:141-53.
    • (2000) Mech Ageing Devel , vol.116 , pp. 141-153
    • Joseph, J.A.1    Denisova, N.2    Bielinski, D.3    Fisher, D.R.4    Shukitt-Hale, D.5
  • 15
    • 0032189767 scopus 로고    scopus 로고
    • Long-term dietary strawberry, spinach or vitamin E supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioral deficits
    • Joseph JA, Shukitt-Hale B, Denisova NA, Prior RL, Cao G, Martin A, et al. Long-term dietary strawberry, spinach or vitamin E supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioral deficits. J Neurosci 1998;18:8047-55.
    • (1998) J Neurosci , vol.18 , pp. 8047-8055
    • Joseph, J.A.1    Shukitt-Hale, B.2    Denisova, N.A.3    Prior, R.L.4    Cao, G.5    Martin, A.6
  • 16
    • 0033568849 scopus 로고    scopus 로고
    • Reversals of age-related declines in neuronal signal transduction, cognitive and motor behavioral deficits with blueberry, spinach or strawberry dietary supplementation
    • Joseph JA, Shukitt-Hale B, Denisova NA, Bielinski D, Martin A, McEwen JJ, et al. Reversals of age-related declines in neuronal signal transduction, cognitive and motor behavioral deficits with blueberry, spinach or strawberry dietary supplementation. J Neurosci 1999;19:8114-21.
    • (1999) J Neurosci , vol.19 , pp. 8114-8121
    • Joseph, J.A.1    Shukitt-Hale, B.2    Denisova, N.A.3    Bielinski, D.4    Martin, A.5    McEwen, J.J.6
  • 17
    • 0031745637 scopus 로고    scopus 로고
    • Comparison of different analytical methods for assessing total antioxidant capacity of human serum
    • Cao G, Prior RL. Comparison of different analytical methods for assessing total antioxidant capacity of human serum. Clin Chem 1998;44:1309-15.
    • (1998) Clin Chem , vol.44 , pp. 1309-1315
    • Cao, G.1    Prior, R.L.2
  • 19
    • 0036902931 scopus 로고    scopus 로고
    • Feeding rats diets enriched in lowbush blueberries for six weeks decreases ischemia-induced brain damage
    • Sweeney MI, Kalt W, MacKinnon SL, Ashby J, Gottschall-Pass KT. Feeding rats diets enriched in lowbush blueberries for six weeks decreases ischemia-induced brain damage. Nutr Neurosci 2002;5:427-31.
    • (2002) Nutr Neurosci , vol.5 , pp. 427-431
    • Sweeney, M.I.1    Kalt, W.2    Mackinnon, S.L.3    Ashby, J.4    Gottschall-Pass, K.T.5
  • 20
    • 0037736704 scopus 로고    scopus 로고
    • Blueberry supplementation enhances signalling and prevents behavioral deficits in an Alzheimer disease model
    • Joseph JA, Denisova N, Arendash G, Gordon M, Diamond D, Shukitt-Hale B, et al. Blueberry supplementation enhances signalling and prevents behavioral deficits in an Alzheimer disease model. Nutr Neurosci 2003;6:153-62.
    • (2003) Nutr Neurosci , vol.6 , pp. 153-162
    • Joseph, J.A.1    Denisova, N.2    Arendash, G.3    Gordon, M.4    Diamond, D.5    Shukitt-Hale, B.6
  • 21
    • 12344311870 scopus 로고    scopus 로고
    • Modulation of hippocampal plasticity and and cognitive behaviour by short-term blueberry supplementation in aged rats
    • Casadesus G, Shukitt-Hale B, Stellwagen HM, Zhu X, Lee HG, Smith MA, et al. Modulation of hippocampal plasticity and and cognitive behaviour by short-term blueberry supplementation in aged rats. Nutr Neurosci 2004;7:309-16.
    • (2004) Nutr Neurosci , vol.7 , pp. 309-316
    • Casadesus, G.1    Shukitt-Hale, B.2    Stellwagen, H.M.3    Zhu, X.4    Lee, H.G.5    Smith, M.A.6
  • 22
    • 3242715885 scopus 로고    scopus 로고
    • Blueberry supplemented diet: Effects on object recognition memory and nuclear factor-kappa B levels in aged rats
    • Goyarzu P, Malin DH, Lau FC, Taglialatela G, Moon WD, Jennings R, et al. Blueberry supplemented diet: effects on object recognition memory and nuclear factor-kappa B levels in aged rats. Nutr Neurosci 2004;7:75-83.
    • (2004) Nutr Neurosci , vol.7 , pp. 75-83
    • Goyarzu, P.1    Malin, D.H.2    Lau, F.C.3    Taglialatela, G.4    Moon, W.D.5    Jennings, R.6
  • 26
    • 34249279788 scopus 로고    scopus 로고
    • Beneficial effects of fruit extracts on neuronal function and behaviour in a rodent model of accelerated aging
    • Shukitt-Hale B, Carey AN, Jenkins D, Rabin BM, Joseph JA. Beneficial effects of fruit extracts on neuronal function and behaviour in a rodent model of accelerated aging. Neurobiol Aging 2006;28:1187-84.
    • (2006) Neurobiol Aging , vol.28 , pp. 1184-1187
    • Shukitt-Hale, B.1    Carey, A.N.2    Jenkins, D.3    Rabin, B.M.4    Joseph, J.A.5
  • 27
    • 13844281685 scopus 로고    scopus 로고
    • Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
    • Manach C, Williamson G, Morand C, Scalbert A, Rémésy C. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 2005;81:230-42.
    • (2005) Am J Clin Nutr , vol.81 , pp. 230-242
    • Manach, C.1    Williamson, G.2    Morand, C.3    Scalbert, A.4    Rémésy, C.5
  • 28
    • 26944459671 scopus 로고    scopus 로고
    • Diet as a factor in behavioral radiation protection following exposure to heavy particles
    • Rabin BM, Shukitt-Hale B, Joseph JA, Todd P. Diet as a factor in behavioral radiation protection following exposure to heavy particles. Gravitat Space Biol 2005;18:11-7.
    • (2005) Gravitat Space Biol , vol.18 , pp. 11-17
    • Rabin, B.M.1    Shukitt-Hale, B.2    Joseph, J.A.3    Todd, P.4
  • 29
    • 0031960552 scopus 로고    scopus 로고
    • Age-related activation of microglia and astrocytes: In vitro studies show persistent phenotypes of aging, increased proliferation, and resistance to downregulation
    • Rozovsky I, Finch CE, Morgan TE. Age-related activation of microglia and astrocytes: in vitro studies show persistent phenotypes of aging, increased proliferation, and resistance to downregulation. Neurobiol Aging 1998;19:97-103.
    • (1998) Neurobiol Aging , vol.19 , pp. 97-103
    • Rozovsky, I.1    Finch, C.E.2    Morgan, T.E.3
  • 30
    • 0029610011 scopus 로고
    • The inflammatory response system of the brain: Implications for therapy of Alzheimer and other neurodegenerative diseases
    • McGeer PL, McGeer EG. The inflammatory response system of the brain: implications for therapy of Alzheimer and other neurodegenerative diseases. Brain Res Rev 1995;21:195-218.
    • (1995) Brain Res Rev , vol.21 , pp. 195-218
    • McGeer, P.L.1    McGeer, E.G.2
  • 31
    • 0030417935 scopus 로고    scopus 로고
    • The relationship of aging to endotoxic shock and to production of TNF-α
    • Chang HN, Wang SR, Chiang SC. The relationship of aging to endotoxic shock and to production of TNF-α. J Gerontol 1996; 51:220-2.
    • (1996) J Gerontol , vol.51 , pp. 220-222
    • Chang, H.N.1    Wang, S.R.2    Chiang, S.C.3
  • 32
    • 0035116418 scopus 로고    scopus 로고
    • Neurons reduce glial responses to lipopolysaccharide (LPS) and prevent injury of microglial cells from over-activaction by LPS
    • Chang RC, Chen W, Hudson P, Wilson B, Han DS, Hong JS. Neurons reduce glial responses to lipopolysaccharide (LPS) and prevent injury of microglial cells from over-activaction by LPS. J Neurochem 2001;76:1042-49.
    • (2001) J Neurochem , vol.76 , pp. 1042-1049
    • Chang, R.C.1    Chen, W.2    Hudson, P.3    Wilson, B.4    Han, D.S.5    Hong, J.S.6
  • 33
    • 0030929766 scopus 로고    scopus 로고
    • Caloric restriction inhibits the age-related dysregulation of the cytokines TNF-α and IL-6 in C3B10RF1 mice
    • Spaulding CC, Walford RL, Effros RB. Caloric restriction inhibits the age-related dysregulation of the cytokines TNF-α and IL-6 in C3B10RF1 mice. Mech Ageing Dev 1997;93:87-94.
    • (1997) Mech Ageing Dev , vol.93 , pp. 87-94
    • Spaulding, C.C.1    Walford, R.L.2    Effros, R.B.3
  • 34
    • 0035916309 scopus 로고    scopus 로고
    • Cardiovascular disease, interleukin-6, and risk of mortality in older women: The women's health and aging study
    • Volpato S, Guralnik JM, Ferrucci L, Balfour J, Chaves P, Fried LP, et al. Cardiovascular disease, interleukin-6, and risk of mortality in older women: the women's health and aging study. Circulation 2001;103:947-53.
    • (2001) Circulation , vol.103 , pp. 947-953
    • Volpato, S.1    Guralnik, J.M.2    Ferrucci, L.3    Balfour, J.4    Chaves, P.5    Fried, L.P.6
  • 35
    • 0035374364 scopus 로고    scopus 로고
    • C-reactive protein elevation can be caused by conditions other than inflammation and may reflect biologic aging
    • Kushner I. C-reactive protein elevation can be caused by conditions other than inflammation and may reflect biologic aging. Cleve Clin J Med 2001;68:535-7.
    • (2001) Cleve Clin J Med , vol.68 , pp. 535-537
    • Kushner, I.1
  • 36
    • 29844435927 scopus 로고    scopus 로고
    • Blueberry supplemented diet reverses age-related decline in hippocampal HSP70 neuroprotection
    • Galli RL, Bielinski DF, Szprengiel A, Shukitt-Hale B, Joseph JA. Blueberry supplemented diet reverses age-related decline in hippocampal HSP70 neuroprotection. Neurobiol Aging 2006; 27:344-50.
    • (2006) Neurobiol Aging , vol.27 , pp. 344-350
    • Galli, R.L.1    Bielinski, D.F.2    Szprengiel, A.3    Shukitt-Hale, B.4    Joseph, J.A.5
  • 37
    • 34147196050 scopus 로고    scopus 로고
    • Inhibitory effects of blueberry extract on the the production of inflammatory mediators in lipopolysaccharide- activated BV2 microglia
    • Lau FC, Bielinski DF, Joseph JA. Inhibitory effects of blueberry extract on the the production of inflammatory mediators in lipopolysaccharide- activated BV2 microglia. J Neurosci Res 2007; 85:1010-17.
    • (2007) J Neurosci Res , vol.85 , pp. 1010-1017
    • Lau, F.C.1    Bielinski, D.F.2    Joseph, J.A.3
  • 38
    • 54249154215 scopus 로고    scopus 로고
    • Blueberry opposes β-amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activation protein kinase
    • Zhu Y, Bickford PC, Sanberg P, Giunta B, Tan J. Blueberry opposes β-amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activation protein kinase. Rejuvenation Res 2008;11:891-901.
    • (2008) Rejuvenation Res , vol.11 , pp. 891-901
    • Zhu, Y.1    Bickford, P.C.2    Sanberg, P.3    Giunta, B.4    Tan, J.5
  • 40
    • 50449095115 scopus 로고    scopus 로고
    • Blueberry polyphenols attenuate kainic acid-induced decrements in cognition and alter inflammatory gene expression in rat hippocampus
    • Shukitt-Hale B, Lau FC, Carey AN, Galli RL, Spangler EL, Ingram DK, et al. Blueberry polyphenols attenuate kainic acid-induced decrements in cognition and alter inflammatory gene expression in rat hippocampus. Nutr Neurosci 2008;11: 172-82.
    • (2008) Nutr Neurosci , vol.11 , pp. 172-182
    • Shukitt-Hale, B.1    Lau, F.C.2    Carey, A.N.3    Galli, R.L.4    Spangler, E.L.5    Ingram, D.K.6
  • 41
    • 51449092443 scopus 로고    scopus 로고
    • A blueberry-enriched diet provides cellular protection against oxidative stress and reduces a kainate-induced learning impairment in rats
    • Duffy KB, Spangler EL, Devan BD, Guo Z, Bowker ZL, Janas AM, et al. A blueberry-enriched diet provides cellular protection against oxidative stress and reduces a kainate-induced learning impairment in rats. Neurobiol Aging 2008;29:1680-89.
    • (2008) Neurobiol Aging , vol.29 , pp. 1680-1689
    • Duffy, K.B.1    Spangler, E.L.2    Devan, B.D.3    Guo, Z.4    Bowker, Z.L.5    Janas, A.M.6
  • 42
    • 46749094132 scopus 로고    scopus 로고
    • Blueberry-induced changes in spatial working memory correlate in changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels
    • Williams CM, Mohsen MAE, Vauzour D, Rendeiro C, Butler LT, Ellis JA, et al. Blueberry-induced changes in spatial working memory correlate in changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels. Free Rad Biol Med 2008;45:295-305.
    • (2008) Free Rad Biol Med , vol.45 , pp. 295-305
    • Williams, C.M.1    Mohsen, M.A.E.2    Vauzour, D.3    Rendeiro, C.4    Butler, L.T.5    Ellis, J.A.6
  • 43
    • 56749160169 scopus 로고    scopus 로고
    • Blueberry-enriched diet can ameliorates age-related declines in NMDA receptordependent LTP
    • Coultrap SJ, Bickford PC, Browning MD. Blueberry-enriched diet can ameliorates age-related declines in NMDA receptordependent LTP. Age 2008;30:263-72.
    • (2008) Age , vol.30 , pp. 263-272
    • Coultrap, S.J.1    Bickford, P.C.2    Browning, M.D.3
  • 44
    • 0031040861 scopus 로고    scopus 로고
    • Cognitive functions of cortical acetylcholine: Towards a unifying hypothesis
    • Sarter M, Bruno JP. Cognitive functions of cortical acetylcholine: towards a unifying hypothesis. Brain Res Rev 1997;23: 28-46.
    • (1997) Brain Res Rev , vol.23 , pp. 28-46
    • Sarter, M.1    Bruno, J.P.2
  • 45
    • 18744414554 scopus 로고    scopus 로고
    • Acetylcholinesterase: 'classical' and 'nonclassical' functions and pharmacology
    • Silman I, Sussman JL. Acetylcholinesterase: 'classical' and 'nonclassical' functions and pharmacology. Curr Opin Pharmacol 2005;5:293-302.
    • (2005) Curr Opin Pharmacol , vol.5 , pp. 293-302
    • Silman, I.1    Sussman, J.L.2
  • 46
    • 59649099426 scopus 로고    scopus 로고
    • Effect of a polyphenol-rich wild blueberry extract on cognitive performance of mice, brain antioxidant markers and acetylcholinesterase activity
    • Papandreou MA, Dimakopoulou A, Linardaki I, Cordopatis P, Klimis-Zakas D, Margarity M, et al. Effect of a polyphenol-rich wild blueberry extract on cognitive performance of mice, brain antioxidant markers and acetylcholinesterase activity. Behav Brain Res 2009;198:352-8.
    • (2009) Behav Brain Res , vol.198 , pp. 352-358
    • Papandreou, M.A.1    Dimakopoulou, A.2    Linardaki, I.3    Cordopatis, P.4    Klimis-Zakas, D.5    Margarity, M.6
  • 48
    • 79959832398 scopus 로고    scopus 로고
    • Biotransformed blueberry juice protects neurons from hydrogen peroxideinduced oxidative stress and mitogen-activated protein kinase pathway alterations
    • Vuong T, Matar C, Ramassamy C, Haddad PS. Biotransformed blueberry juice protects neurons from hydrogen peroxideinduced oxidative stress and mitogen-activated protein kinase pathway alterations. Br J Nutr 2010;12:1-8.
    • (2010) Br J Nutr , vol.12 , pp. 1-8
    • Vuong, T.1    Matar, C.2    Ramassamy, C.3    Haddad, P.S.4


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